Temperature responsive hydrogel magnetic nanocomposites for hyperthermia and metal extraction applications

The present work deals with the development of temperature and magnetic responsive hydrogel networks based on poly (N-isopropylacrylamide)/acrylamido propane sulfonic acid. The hydrogel matrices are synthesized by polymerizing N-isopropylacrylamide (NIPAM) monomer in the presence of acrylamido propa...

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Veröffentlicht in:Journal of magnetism and magnetic materials 2015-11, Vol.394, p.237-244
Hauptverfasser: Reddy, N. Narayana, Ravindra, S., Reddy, N. Madhava, Rajinikanth, V., Raju, K. Mohana, Vallabhapurapu, Vijaya Srinivasu
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container_end_page 244
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container_start_page 237
container_title Journal of magnetism and magnetic materials
container_volume 394
creator Reddy, N. Narayana
Ravindra, S.
Reddy, N. Madhava
Rajinikanth, V.
Raju, K. Mohana
Vallabhapurapu, Vijaya Srinivasu
description The present work deals with the development of temperature and magnetic responsive hydrogel networks based on poly (N-isopropylacrylamide)/acrylamido propane sulfonic acid. The hydrogel matrices are synthesized by polymerizing N-isopropylacrylamide (NIPAM) monomer in the presence of acrylamido propane sulphonicacid (AMPS) using a cross-linker (N,N-methylenebisacrylamide, MBA) and redox initiating system [ammonium persulphate (APS)/tetramethylethylenediamine (TMEDA)]. The magnetic nanoparticles are generated throughout the hydrogel networks using in situ method by incorporating iron ions and subsequent treatment with ammonia. A series of hydrogel-magnetic nanocomposites (HGMNC) are developed by varying AMPS composition. The synthesized hydrogel magnetic nanocomposites (HGMNC) are characterized by using Fourier Transform Infrared (FTIR) Spectroscopy, X-ray diffraction (XRD), Thermal Analyses and Electron Microscopy analysis (Scanning and Transmission Electron Microscope). The metal extraction capacities of the prepared hydrogel (HG) and hydrogel magnetic nanocomposites (HGMNC) were studied at different temperatures. The results suggest that HGMNCs have higher extraction capacity compared to HG and HG loaded iron ions. This data also reveals that the extraction of metals by hydrogel magnetic nanocomposites (HGMNCs) is higher at higher temperatures than room temperature. The prepared HGMNCs are also subjected to hyperthermia (cancer therapy) studies. •We have developed temperature responsive hydrogel magnetic nanocomposites.•Addition of AMPS monomer to this magnetic hydrogel enhances the temperature sensitivity to 40–43°C.•Similarly the sulfonic groups present in the AMPS units enhances the swelling ratio of magnetic hydrogels.•AMPS acts as good stabilizing agent for nanoparticles in the magnetic nanogel.
doi_str_mv 10.1016/j.jmmm.2015.06.065
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A series of hydrogel-magnetic nanocomposites (HGMNC) are developed by varying AMPS composition. The synthesized hydrogel magnetic nanocomposites (HGMNC) are characterized by using Fourier Transform Infrared (FTIR) Spectroscopy, X-ray diffraction (XRD), Thermal Analyses and Electron Microscopy analysis (Scanning and Transmission Electron Microscope). The metal extraction capacities of the prepared hydrogel (HG) and hydrogel magnetic nanocomposites (HGMNC) were studied at different temperatures. The results suggest that HGMNCs have higher extraction capacity compared to HG and HG loaded iron ions. This data also reveals that the extraction of metals by hydrogel magnetic nanocomposites (HGMNCs) is higher at higher temperatures than room temperature. 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The magnetic nanoparticles are generated throughout the hydrogel networks using in situ method by incorporating iron ions and subsequent treatment with ammonia. A series of hydrogel-magnetic nanocomposites (HGMNC) are developed by varying AMPS composition. The synthesized hydrogel magnetic nanocomposites (HGMNC) are characterized by using Fourier Transform Infrared (FTIR) Spectroscopy, X-ray diffraction (XRD), Thermal Analyses and Electron Microscopy analysis (Scanning and Transmission Electron Microscope). The metal extraction capacities of the prepared hydrogel (HG) and hydrogel magnetic nanocomposites (HGMNC) were studied at different temperatures. The results suggest that HGMNCs have higher extraction capacity compared to HG and HG loaded iron ions. This data also reveals that the extraction of metals by hydrogel magnetic nanocomposites (HGMNCs) is higher at higher temperatures than room temperature. 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subjects Biomaterials
Composite materials
Extraction
Fourier transforms
Hydrogels
Iron
Magnetic materials
Nanocomposites
Networks
Polymers
Propane
Scanning electron microscopy
title Temperature responsive hydrogel magnetic nanocomposites for hyperthermia and metal extraction applications
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