Covalent Bond or Noncovalent Bond: A Supramolecular Strategy for the Construction of Chemically Synthesized Vaccines
A novel noncovalent strategy to construct chemically synthesized vaccines has been designed to trigger a robust immune response and to dramatically improve the efficiency of vaccine preparation. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]ur...
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| Veröffentlicht in: | Chemistry : a European journal 2014-10, Vol.20 (42), p.13541-13546 |
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| container_issue | 42 |
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| container_title | Chemistry : a European journal |
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| creator | Gao, Yue Sun, Zhan-Yi Huang, Zhi-Hua Chen, Pu-Guang Chen, Yong-Xiang Zhao, Yu-Fen Li, Yan-Mei |
| description | A novel noncovalent strategy to construct chemically synthesized vaccines has been designed to trigger a robust immune response and to dramatically improve the efficiency of vaccine preparation. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement‐dependent cytotoxicity. This noncovalent strategy with good suitability, scalability, and feasibility can be applied as a universal strategy for the construction of chemically synthesized vaccines.
Resistance training: A novel noncovalent strategy to construct chemically synthesized vaccines (see figure) has been designed. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement‐dependent cytotoxicity. |
| doi_str_mv | 10.1002/chem.201404013 |
| format | Article |
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Resistance training: A novel noncovalent strategy to construct chemically synthesized vaccines (see figure) has been designed. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement‐dependent cytotoxicity.</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201404013</identifier><identifier>PMID: 25155367</identifier><identifier>CODEN: CEUJED</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Animals ; Antibiotics ; Antibodies ; Antisera ; antitumor vaccines ; Bridged-Ring Compounds - chemistry ; Cancer Vaccines - chemistry ; Cancer Vaccines - immunology ; Cell Line, Tumor ; Chemistry ; Construction ; Covalent bonds ; cucurbituril ; Cytokines ; Cytotoxicity ; Feasibility studies ; Female ; glycopeptides ; Glycosylation ; host-guest systems ; Humans ; IgG antibody ; Imidazoles - chemistry ; Immune response ; Immune system ; Immunoglobulin G ; Level (quantity) ; Mice, Inbred BALB C ; Mucin-1 - chemistry ; Mucin-1 - immunology ; Neoplasms - immunology ; Neoplasms - prevention & control ; Organic chemistry ; Secretions ; Strategy ; Synthesis ; Toxicity ; Transformed cells ; Vaccines ; Vaccines, Synthetic - chemistry ; Vaccines, Synthetic - immunology</subject><ispartof>Chemistry : a European journal, 2014-10, Vol.20 (42), p.13541-13546</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright Wiley Subscription Services, Inc. Oct 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6123-ffaea3ad2e9a5aba26a29f11e1ed3b8163213836715ec735783eb535da25b203</citedby><cites>FETCH-LOGICAL-c6123-ffaea3ad2e9a5aba26a29f11e1ed3b8163213836715ec735783eb535da25b203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201404013$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201404013$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25155367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Yue</creatorcontrib><creatorcontrib>Sun, Zhan-Yi</creatorcontrib><creatorcontrib>Huang, Zhi-Hua</creatorcontrib><creatorcontrib>Chen, Pu-Guang</creatorcontrib><creatorcontrib>Chen, Yong-Xiang</creatorcontrib><creatorcontrib>Zhao, Yu-Fen</creatorcontrib><creatorcontrib>Li, Yan-Mei</creatorcontrib><title>Covalent Bond or Noncovalent Bond: A Supramolecular Strategy for the Construction of Chemically Synthesized Vaccines</title><title>Chemistry : a European journal</title><addtitle>Chem. Eur. J</addtitle><description>A novel noncovalent strategy to construct chemically synthesized vaccines has been designed to trigger a robust immune response and to dramatically improve the efficiency of vaccine preparation. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement‐dependent cytotoxicity. This noncovalent strategy with good suitability, scalability, and feasibility can be applied as a universal strategy for the construction of chemically synthesized vaccines.
Resistance training: A novel noncovalent strategy to construct chemically synthesized vaccines (see figure) has been designed. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement‐dependent cytotoxicity.</description><subject>Animals</subject><subject>Antibiotics</subject><subject>Antibodies</subject><subject>Antisera</subject><subject>antitumor vaccines</subject><subject>Bridged-Ring Compounds - chemistry</subject><subject>Cancer Vaccines - chemistry</subject><subject>Cancer Vaccines - immunology</subject><subject>Cell Line, Tumor</subject><subject>Chemistry</subject><subject>Construction</subject><subject>Covalent bonds</subject><subject>cucurbituril</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Feasibility studies</subject><subject>Female</subject><subject>glycopeptides</subject><subject>Glycosylation</subject><subject>host-guest systems</subject><subject>Humans</subject><subject>IgG antibody</subject><subject>Imidazoles - chemistry</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunoglobulin G</subject><subject>Level (quantity)</subject><subject>Mice, Inbred BALB C</subject><subject>Mucin-1 - chemistry</subject><subject>Mucin-1 - immunology</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - prevention & control</subject><subject>Organic chemistry</subject><subject>Secretions</subject><subject>Strategy</subject><subject>Synthesis</subject><subject>Toxicity</subject><subject>Transformed cells</subject><subject>Vaccines</subject><subject>Vaccines, Synthetic - chemistry</subject><subject>Vaccines, Synthetic - immunology</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQRi0EokvhyhFZ4sIli-2J7YRbG5UWaVmEtipHy3EmNCUbL3YChF-Pqy2rigM9WbLe9-yZj5CXnC05Y-Ktu8btUjCes5xxeEQWXAqegVbyMVmwMteZklAekWcx3jDGSgXwlBwJyaUEpRdkrPwP2-Mw0lM_NNQHuvaDu3_3jp7QzbQLdut7dFNvA92MwY74daZt4sdrpJUf4hgmN3Z-oL6lVfpV52zfz3QzD4mI3W9s6JV1rhswPidPWttHfHF3HpPL92eX1UW2-nT-oTpZZU5xAVnbWrRgG4Gllba2QllRtpwjxwbqgisQHIo0BpfoNEhdANYSZGOFrAWDY_Jmr90F_33COJptFx32vR3QT9FwXSieNiLhYVSxEpgGUSb09T_ojZ_CkOYwQvC8KLT-P8VlelZIpvJELfeUCz7GgK3ZhW5rw2w4M7f9mtt-zaHfFHh1p53qLTYH_G-hCSj3wM-ux_kBnakuzj7el2f7bBdH_HXI2vDNJLOW5sv63KjPp2ot2ZVZwR_iS7-Z</recordid><startdate>20141013</startdate><enddate>20141013</enddate><creator>Gao, Yue</creator><creator>Sun, Zhan-Yi</creator><creator>Huang, Zhi-Hua</creator><creator>Chen, Pu-Guang</creator><creator>Chen, Yong-Xiang</creator><creator>Zhao, Yu-Fen</creator><creator>Li, Yan-Mei</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20141013</creationdate><title>Covalent Bond or Noncovalent Bond: A Supramolecular Strategy for the Construction of Chemically Synthesized Vaccines</title><author>Gao, Yue ; Sun, Zhan-Yi ; Huang, Zhi-Hua ; Chen, Pu-Guang ; Chen, Yong-Xiang ; Zhao, Yu-Fen ; Li, Yan-Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6123-ffaea3ad2e9a5aba26a29f11e1ed3b8163213836715ec735783eb535da25b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Antibiotics</topic><topic>Antibodies</topic><topic>Antisera</topic><topic>antitumor vaccines</topic><topic>Bridged-Ring Compounds - chemistry</topic><topic>Cancer Vaccines - chemistry</topic><topic>Cancer Vaccines - immunology</topic><topic>Cell Line, Tumor</topic><topic>Chemistry</topic><topic>Construction</topic><topic>Covalent bonds</topic><topic>cucurbituril</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Feasibility studies</topic><topic>Female</topic><topic>glycopeptides</topic><topic>Glycosylation</topic><topic>host-guest systems</topic><topic>Humans</topic><topic>IgG antibody</topic><topic>Imidazoles - chemistry</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunoglobulin G</topic><topic>Level (quantity)</topic><topic>Mice, Inbred BALB C</topic><topic>Mucin-1 - chemistry</topic><topic>Mucin-1 - immunology</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - prevention & control</topic><topic>Organic chemistry</topic><topic>Secretions</topic><topic>Strategy</topic><topic>Synthesis</topic><topic>Toxicity</topic><topic>Transformed cells</topic><topic>Vaccines</topic><topic>Vaccines, Synthetic - chemistry</topic><topic>Vaccines, Synthetic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Yue</creatorcontrib><creatorcontrib>Sun, Zhan-Yi</creatorcontrib><creatorcontrib>Huang, Zhi-Hua</creatorcontrib><creatorcontrib>Chen, Pu-Guang</creatorcontrib><creatorcontrib>Chen, Yong-Xiang</creatorcontrib><creatorcontrib>Zhao, Yu-Fen</creatorcontrib><creatorcontrib>Li, Yan-Mei</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Yue</au><au>Sun, Zhan-Yi</au><au>Huang, Zhi-Hua</au><au>Chen, Pu-Guang</au><au>Chen, Yong-Xiang</au><au>Zhao, Yu-Fen</au><au>Li, Yan-Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Covalent Bond or Noncovalent Bond: A Supramolecular Strategy for the Construction of Chemically Synthesized Vaccines</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chem. Eur. J</addtitle><date>2014-10-13</date><risdate>2014</risdate><volume>20</volume><issue>42</issue><spage>13541</spage><epage>13546</epage><pages>13541-13546</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><coden>CEUJED</coden><abstract>A novel noncovalent strategy to construct chemically synthesized vaccines has been designed to trigger a robust immune response and to dramatically improve the efficiency of vaccine preparation. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement‐dependent cytotoxicity. This noncovalent strategy with good suitability, scalability, and feasibility can be applied as a universal strategy for the construction of chemically synthesized vaccines.
Resistance training: A novel noncovalent strategy to construct chemically synthesized vaccines (see figure) has been designed. Glycosylated MUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril. These vaccines elicited high levels of IgG antibodies that were recognized by transformed cells and induced the secretion of cytokines. The antisera also mediated complement‐dependent cytotoxicity.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>25155367</pmid><doi>10.1002/chem.201404013</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Antibiotics Antibodies Antisera antitumor vaccines Bridged-Ring Compounds - chemistry Cancer Vaccines - chemistry Cancer Vaccines - immunology Cell Line, Tumor Chemistry Construction Covalent bonds cucurbituril Cytokines Cytotoxicity Feasibility studies Female glycopeptides Glycosylation host-guest systems Humans IgG antibody Imidazoles - chemistry Immune response Immune system Immunoglobulin G Level (quantity) Mice, Inbred BALB C Mucin-1 - chemistry Mucin-1 - immunology Neoplasms - immunology Neoplasms - prevention & control Organic chemistry Secretions Strategy Synthesis Toxicity Transformed cells Vaccines Vaccines, Synthetic - chemistry Vaccines, Synthetic - immunology |
| title | Covalent Bond or Noncovalent Bond: A Supramolecular Strategy for the Construction of Chemically Synthesized Vaccines |
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