Structural and functional evaluation of interaction between mammalian ribosomal RNA with platinum-containing antineoplastic drugs

[Display omitted] •Destabilised green fluorescent protein to monitor translation efficiency.•Equitoxic concentrations of cisplatin, carboplatin and oxaliplatin lead to same rRNA platination patterns and intensity.•Typical plasma levels of cisplatin, carboplatin and oxaliplatin do not inhibit transla...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology letters 2016-02, Vol.242, p.47-52
Hauptverfasser:	Theile, Dirk, Kos, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biocompatibility Carboplatin Carboplatin - chemistry Carboplatin - pharmacokinetics Carboplatin - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Cisplatin Cisplatin - chemistry Cisplatin - pharmacokinetics Cisplatin - pharmacology Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Dose-Response Relationship, Drug Drugs Exposure Flow cytometry Fluorescence Gene Expression Regulation, Neoplastic Green Fluorescent Proteins - biosynthesis Green Fluorescent Proteins - genetics Humans Inhibitory Concentration 50 Molecular Structure Nucleic Acid Conformation Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacokinetics Organoplatinum Compounds - pharmacology Oxaliplatin Platinum Primer extension Protein Biosynthesis Ribonucleic acids Ribosomal RNA RNA, Ribosomal - chemistry RNA, Ribosomal - metabolism Structure-Activity Relationship Translation efficiency Translations
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!