Accelerated bony defect healing by chitosan/silica hybrid membrane with localized bone morphogenetic protein-2 delivery

Therapeutic agents such as growth factors have been widely applied to promote bone regeneration with implantable biomaterials. In this study, a hybrid of chitosan–xerogel membrane was combined with bone morphogenetic protein-2 (BMP-2) for enhancing bone regeneration. The characteristics of the hybri...

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Veröffentlicht in:	Materials Science & Engineering C 2016-02, Vol.59, p.339-345
Hauptverfasser:	Lee, Eun-Jung, Kim, Hyoun-Ee
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical materials Bone Morphogenetic Protein 2 - pharmacology Bone morphogenetic protein-2 Bone Regeneration - drug effects Bones Cell Line Cellular Chitosan Chitosan - pharmacology Delivery Drug Delivery Systems - methods Fracture Healing - drug effects Healing Hybrid composite In vivo methods and tests Male Membranes Membranes, Artificial Mice Rats Rats, Sprague-Dawley Regeneration Silicon Dioxide - pharmacology Sol–gel methods Tissue regeneration
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