Effects of macromolecular crowding on the collapse of biopolymers

Experiments show that macromolecular crowding modestly reduces the size of intrinsically disordered proteins even at a volume fraction (ϕ) similar to that in the cytosol, whereas DNA undergoes a coil-to-globule transition at very small ϕ. We show using a combination of scaling arguments and simulati...

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Veröffentlicht in:	Physical review letters 2015-02, Vol.114 (6), p.068303-068303, Article 068303
Hauptverfasser:	Kang, Hongsuk, Pincus, Philip A, Hyeon, Changbong, Thirumalai, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopolymers Coiling Collapse Computer Simulation Crowding Deoxyribonucleic acid DNA - chemistry Macromolecular Substances - chemistry Models, Chemical Nucleic Acid Conformation Protein Conformation Proteins Proteins - chemistry Simulation Volume fraction
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