Effective temperature of mutations
Biological macromolecules experience two seemingly very different types of noise acting on different time scales: (i) point mutations corresponding to changes in molecular sequence and (ii) thermal fluctuations. Examining the secondary structures of a large number of microRNA precursor sequences and...
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| Veröffentlicht in: | Physical review letters 2015-02, Vol.114 (5), p.058101-058101, Article 058101 |
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| container_end_page | 058101 |
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| container_issue | 5 |
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| container_title | Physical review letters |
| container_volume | 114 |
| creator | Derenyi, Imre Szollosi, Gergely J |
| description | Biological macromolecules experience two seemingly very different types of noise acting on different time scales: (i) point mutations corresponding to changes in molecular sequence and (ii) thermal fluctuations. Examining the secondary structures of a large number of microRNA precursor sequences and model lattice proteins, we show that the effects of single point mutations are statistically indistinguishable from those of an increase in temperature by a few tens of kelvins. The existence of such an effective mutational temperature establishes a quantitative connection between robustness to genetic (mutational) and environmental (thermal) perturbations. |
| doi_str_mv | 10.1103/PhysRevLett.114.058101 |
| format | Article |
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| ispartof | Physical review letters, 2015-02, Vol.114 (5), p.058101-058101, Article 058101 |
| issn | 0031-9007 1079-7114 |
| language | eng |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Fluctuation Genetics Lattices MicroRNAs - chemistry MicroRNAs - genetics Models, Genetic Molecular structure Mutations Nucleic Acid Conformation Perturbation methods Point Mutation Precursors Robustness Temperature |
| title | Effective temperature of mutations |
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