Designed Benzothiadiazole Fluorophores for Selective Mitochondrial Imaging and Dynamics

A series of new rationale designed 2,1,3‐benzothiadiazole (BTD) fluorescent derivatives has been synthesized and applied for cellular selective staining of cancer cells in cell‐imaging experiments. Four new synthesized BTD derivatives showed only poor or reasonable cellular selection, but with excel...

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Veröffentlicht in:	Chemistry : a European journal 2014-11, Vol.20 (47), p.15360-15374
Hauptverfasser:	Carvalho, Pedro H. P. R., Correa, Jose R., Guido, Bruna C., Gatto, Claudia C., De Oliveira, Heibbe C. B., Soares, Thereza A., Neto, Brenno A. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	benzothiadiazole Binding Sites Cellular Chemistry Crystallography, X-Ray Derivatives Dynamics Experiments Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Humans Imaging live cell imaging Mathematical analysis MCF-7 Cells Microscopy, Confocal mitochondria Mitochondria - metabolism Molecular Conformation Molecular Docking Simulation Quantum Theory Staining Thiadiazoles - chemical synthesis Thiadiazoles - chemistry Thiadiazoles - metabolism Tracking
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