Enantioselective synthesis of hexahydrofuro[3,2-c] quinolines through a multicatalytic and multicomponent process. A new “aromatic sandwich” model for BINOL-phosphoric acid catalyzed reactions

A new and straightforward metal-organo orthogonal-relay catalytic asymmetric reaction for the enantioselective synthesis of hexahydrofuro[3,2-c]quinolines is reported. The process involves a three-component coupling reaction between an alkynol, an aldehyde and an arylamine catalyzed by a gold comple...

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Veröffentlicht in:	Chemical science (Cambridge) 2014, Vol.5 (3), p.996-1007
Hauptverfasser:	Calleja, Jonás, González-Pérez, Adán B., de Lera, Ángel R., Álvarez, Rosana, Fañanás, Francisco J., Rodríguez, Félix
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Asymmetry Chemical reactions Cycloaddition Organic compounds Phosphoric acid Reaction mechanisms Synthesis (chemistry)
Online-Zugang:	Volltext
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