New progress and prospects: The application of nanogel in drug delivery

Nanogel has attracted considerable attention as one of the most versatile drug delivery systems especially for site-specific and/or time-controlled delivery of bioactive agents owing to their combining features of hydrogel and nanoparticle. Physically synthesized nanogels can offer a platform to encapsulate various types of bioactive compounds, particularly hydrophobic drugs and biomacromolecules, but they have poor mechanical stability, whereas nanogels prepared by chemical cross-link have a wider application and larger flexibility. As an ideal drug-delivery carrier, nanogel has excellent drug loading capacity, high stability, biologic consistence and response to a wide variety of environmental stimuli. Nowadays, targeting and response especially multi-response of the nanogel system for drug delivery have become an issue in research. And the application study of nanogels mainly focuses on antitumor agents and proteins. This review focuses on the formation of nanogels (physical and chemical cross-linking) and their release behavior. Recent application of nanogels is also discussed. [Display omitted] •The mechanism of forming nanogel (including physical and chemical cross-linking) was demonstrated.•How the therapeutics released from the nanogels was reviewed, especially stimuli-induced release.•Recent application of nanogel was discussed in this review.•“Lipogel” was also introduced and the future perspective of nanogel was discussed.