Genistein-loaded nanoparticles of star-shaped diblock copolymer mannitol-core PLGA–TPGS for the treatment of liver cancer

The purpose of this research is to develop nanoparticles (NPs) of star-shaped copolymer mannitol-functionalized PLGA–TPGS for Genistein delivery for liver cancer treatment, and evaluate their therapeutic effects in liver cancer cell line and hepatoma-tumor-bearing nude mice in comparison with the li...

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Veröffentlicht in:	Materials Science & Engineering C 2016-02, Vol.59, p.792-800
Hauptverfasser:	Wu, Binquan, Liang, Yong, Tan, Yi, Xie, Chunmei, Shen, Jin, Zhang, Mei, Liu, Xinkuang, Yang, Lixin, Zhang, Fujian, Liu, Liang, Cai, Shuyu, Huai, De, Zheng, Donghui, Zhang, Rongbo, Zhang, Chao, Chen, Ke, Tang, Xiaolong, Sui, Xuemei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Controlled release Copolymers Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Carriers - pharmacology Genistein Genistein - chemistry Genistein - pharmacokinetics Genistein - pharmacology Hep G2 Cells Humans In vitro testing Lactic Acid - chemistry Lactic Acid - pharmacokinetics Lactic Acid - pharmacology Liver Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Mannitol - chemistry Mannitol - pharmacokinetics Mannitol - pharmacology Mice Mice, SCID Nanomedicine Nanoparticles Nanoparticles - chemistry Nanostructure Particle size distribution Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - pharmacology Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacokinetics Polyglycolic Acid - pharmacology Star-shaped copolymer Surface charge Vitamin E - analogs & derivatives Vitamin E - chemistry Vitamin E - pharmacokinetics Vitamin E - pharmacology Xenograft Model Antitumor Assays
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