Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin
An ultra-sensitive electrochemical sensor for the detection of insulin was fabricated, using low-cost and environmentally friendly nickel nanoparticles (NiNPs) by ion implantation. The morphology and structure of the NiNPs are characterized by scanning electron microscopy (SEM), revealing diameters...
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| Veröffentlicht in: | Biosensors & bioelectronics 2016-03, Vol.77, p.215-219 |
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| creator | Yu, Yanan Guo, Meisong Yuan, Mengwei Liu, Weitong Hu, Jingbo |
| description | An ultra-sensitive electrochemical sensor for the detection of insulin was fabricated, using low-cost and environmentally friendly nickel nanoparticles (NiNPs) by ion implantation. The morphology and structure of the NiNPs are characterized by scanning electron microscopy (SEM), revealing diameters ranging from 4 to 8nm. The insulin assay performances were evaluated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (I–t). The NiNPs-modified indium tin oxide electrode (NiNPs/ITO) showed excellent analytical features, including ultra-high sensitivity (2140μAμM−1) for detecting low concentrations of insulin, an incredibly low detection limit (10pM) and a wide dynamic range (100pM to 2400pM and 1nM to 125nM). In addition, the NiNPs/ITO electrode was also used to analyze the insulin concentration in bovine insulin injections. The NiNPs/ITO electrode is expected to be used as a potential biosensor for insulin.
•Ion implantation is an eco-friendly and easy-to-use technique.•NiNPs/ITO electrode shows well electrocatalytic properties of insulin oxidation.•The linear relationship was observed in the wide insulin concentration.•NiNPs/ITO electrode exhibited ultra-high sensitivity and much low detection limit. |
| doi_str_mv | 10.1016/j.bios.2015.09.036 |
| format | Article |
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•Ion implantation is an eco-friendly and easy-to-use technique.•NiNPs/ITO electrode shows well electrocatalytic properties of insulin oxidation.•The linear relationship was observed in the wide insulin concentration.•NiNPs/ITO electrode exhibited ultra-high sensitivity and much low detection limit.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/j.bios.2015.09.036</identifier><identifier>PMID: 26409021</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adsorption ; Biosensors ; Conductometry - instrumentation ; Electrochemical detection ; Electrochemical impedance spectroscopy ; Electrodes ; Equipment Design ; Equipment Failure Analysis ; Indium tin oxide ; Insulin ; Insulin - analysis ; Ion implantation ; Metal Nanoparticles - chemistry ; Microchemistry - instrumentation ; Microelectrodes ; Nanostructure ; Nickel ; Nickel - chemistry ; Nickel nanoparticles ; Reproducibility of Results ; Scanning electron microscopy ; Sensitivity and Specificity ; Tin Compounds - chemistry</subject><ispartof>Biosensors & bioelectronics, 2016-03, Vol.77, p.215-219</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-5a8aea259559763380ef8cba052f3e13965c20e9efa9798e73dd1c203d086e513</citedby><cites>FETCH-LOGICAL-c422t-5a8aea259559763380ef8cba052f3e13965c20e9efa9798e73dd1c203d086e513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0956566315304322$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26409021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Yanan</creatorcontrib><creatorcontrib>Guo, Meisong</creatorcontrib><creatorcontrib>Yuan, Mengwei</creatorcontrib><creatorcontrib>Liu, Weitong</creatorcontrib><creatorcontrib>Hu, Jingbo</creatorcontrib><title>Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>An ultra-sensitive electrochemical sensor for the detection of insulin was fabricated, using low-cost and environmentally friendly nickel nanoparticles (NiNPs) by ion implantation. The morphology and structure of the NiNPs are characterized by scanning electron microscopy (SEM), revealing diameters ranging from 4 to 8nm. The insulin assay performances were evaluated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (I–t). The NiNPs-modified indium tin oxide electrode (NiNPs/ITO) showed excellent analytical features, including ultra-high sensitivity (2140μAμM−1) for detecting low concentrations of insulin, an incredibly low detection limit (10pM) and a wide dynamic range (100pM to 2400pM and 1nM to 125nM). In addition, the NiNPs/ITO electrode was also used to analyze the insulin concentration in bovine insulin injections. The NiNPs/ITO electrode is expected to be used as a potential biosensor for insulin.
•Ion implantation is an eco-friendly and easy-to-use technique.•NiNPs/ITO electrode shows well electrocatalytic properties of insulin oxidation.•The linear relationship was observed in the wide insulin concentration.•NiNPs/ITO electrode exhibited ultra-high sensitivity and much low detection limit.</description><subject>Adsorption</subject><subject>Biosensors</subject><subject>Conductometry - instrumentation</subject><subject>Electrochemical detection</subject><subject>Electrochemical impedance spectroscopy</subject><subject>Electrodes</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Indium tin oxide</subject><subject>Insulin</subject><subject>Insulin - analysis</subject><subject>Ion implantation</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Microchemistry - instrumentation</subject><subject>Microelectrodes</subject><subject>Nanostructure</subject><subject>Nickel</subject><subject>Nickel - chemistry</subject><subject>Nickel nanoparticles</subject><subject>Reproducibility of Results</subject><subject>Scanning electron microscopy</subject><subject>Sensitivity and Specificity</subject><subject>Tin Compounds - chemistry</subject><issn>0956-5663</issn><issn>1873-4235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1PHDEQhq0oKBwffyBFtGWaXcb22WtLNBEiAQmRBmrLZ88qvnjXh72LlH-PTweUEdVIM8-8xfsQ8pVCR4HKi223Cal0DKjoQHfA5Seyoqrn7Zpx8ZmsQAvZCin5MTkpZQsAPdXwhRwzuQYNjK6IuQ_uL8ZmslPa2TwHF7Edkw9DQN9gRDfn5LEZUm6WOGfbFpxKmMMzvl3dHxyDs7HxONdFSFOThiZMZYlhOiNHg40Fz1_nKXn8ef1wddPe_f51e_XjrnVrxuZWWGXRMqGF0L3kXAEOym0sCDZwpFxL4RigxsHqXivsufe0brgHJVFQfkq-H3J3OT0tWGYzhuIwRjthWoqhvZJUgODqI6hgnNfuPoCupZK6p6yi7IC6nErJOJhdDqPN_wwFs9dltmavy-x1GdCm6qpP317zl82I_v3lzU8FLg8A1u6eA2ZTXMDJoQ-5dm18Cv_LfwHy0qa1</recordid><startdate>20160315</startdate><enddate>20160315</enddate><creator>Yu, Yanan</creator><creator>Guo, Meisong</creator><creator>Yuan, Mengwei</creator><creator>Liu, Weitong</creator><creator>Hu, Jingbo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SP</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20160315</creationdate><title>Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin</title><author>Yu, Yanan ; Guo, Meisong ; Yuan, Mengwei ; Liu, Weitong ; Hu, Jingbo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-5a8aea259559763380ef8cba052f3e13965c20e9efa9798e73dd1c203d086e513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adsorption</topic><topic>Biosensors</topic><topic>Conductometry - instrumentation</topic><topic>Electrochemical detection</topic><topic>Electrochemical impedance spectroscopy</topic><topic>Electrodes</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>Indium tin oxide</topic><topic>Insulin</topic><topic>Insulin - analysis</topic><topic>Ion implantation</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Microchemistry - instrumentation</topic><topic>Microelectrodes</topic><topic>Nanostructure</topic><topic>Nickel</topic><topic>Nickel - chemistry</topic><topic>Nickel nanoparticles</topic><topic>Reproducibility of Results</topic><topic>Scanning electron microscopy</topic><topic>Sensitivity and Specificity</topic><topic>Tin Compounds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Yanan</creatorcontrib><creatorcontrib>Guo, Meisong</creatorcontrib><creatorcontrib>Yuan, Mengwei</creatorcontrib><creatorcontrib>Liu, Weitong</creatorcontrib><creatorcontrib>Hu, Jingbo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Yanan</au><au>Guo, Meisong</au><au>Yuan, Mengwei</au><au>Liu, Weitong</au><au>Hu, Jingbo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>2016-03-15</date><risdate>2016</risdate><volume>77</volume><spage>215</spage><epage>219</epage><pages>215-219</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>An ultra-sensitive electrochemical sensor for the detection of insulin was fabricated, using low-cost and environmentally friendly nickel nanoparticles (NiNPs) by ion implantation. The morphology and structure of the NiNPs are characterized by scanning electron microscopy (SEM), revealing diameters ranging from 4 to 8nm. The insulin assay performances were evaluated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (I–t). The NiNPs-modified indium tin oxide electrode (NiNPs/ITO) showed excellent analytical features, including ultra-high sensitivity (2140μAμM−1) for detecting low concentrations of insulin, an incredibly low detection limit (10pM) and a wide dynamic range (100pM to 2400pM and 1nM to 125nM). In addition, the NiNPs/ITO electrode was also used to analyze the insulin concentration in bovine insulin injections. The NiNPs/ITO electrode is expected to be used as a potential biosensor for insulin.
•Ion implantation is an eco-friendly and easy-to-use technique.•NiNPs/ITO electrode shows well electrocatalytic properties of insulin oxidation.•The linear relationship was observed in the wide insulin concentration.•NiNPs/ITO electrode exhibited ultra-high sensitivity and much low detection limit.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>26409021</pmid><doi>10.1016/j.bios.2015.09.036</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adsorption Biosensors Conductometry - instrumentation Electrochemical detection Electrochemical impedance spectroscopy Electrodes Equipment Design Equipment Failure Analysis Indium tin oxide Insulin Insulin - analysis Ion implantation Metal Nanoparticles - chemistry Microchemistry - instrumentation Microelectrodes Nanostructure Nickel Nickel - chemistry Nickel nanoparticles Reproducibility of Results Scanning electron microscopy Sensitivity and Specificity Tin Compounds - chemistry |
| title | Nickel nanoparticle-modified electrode for ultra-sensitive electrochemical detection of insulin |
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