Protective immunity against α-cobratoxin following a single administration of a genetic vaccine encoding a non-toxic cobratoxin variant

Venomous snakebites result in almost 125,000 deaths per year worldwide. We present a new paradigm for the development of vaccines to protect against snakebite, using knowledge of the structure and action of specific toxins combined with a gene-based strategy to deliver a toxin gene modified to rende...

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Veröffentlicht in:	Human gene therapy 2005-03, Vol.16 (3), p.292-298
Hauptverfasser:	PERGOLIZZI, Robert G, DRAGOS, Rachel, ROPPER, Alexander E, MENEZ, André, CRYSTAL, Ronald G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Base Sequence Biological and medical sciences Biotechnology Cobra Neurotoxin Proteins - genetics Cobra Neurotoxin Proteins - immunology Cobra Neurotoxin Proteins - metabolism DNA, Complementary - genetics Female Fundamental and applied biological sciences. Psychology Gene therapy Genetic Vectors Health. Pharmaceutical industry Immunization - methods Industrial applications and implications. Economical aspects Medical sciences Mice Mice, Inbred BALB C Molecular Sequence Data Naja kaouthia Polymerase Chain Reaction Protein Conformation Receptors, Nicotinic - metabolism Snake Bites - immunology Snake Bites - prevention & control Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vaccines, DNA - administration & dosage Vaccines, DNA - immunology
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