Differential effects of Ras signaling through NFκB on skeletal myogenesis

Oncogenic Ras (H-Ras G12V) inhibits skeletal myogenesis through multiple signaling pathways. Previously, we demonstrated that the major downstream effectors of Ras (i.e., MEK/MAPK, RalGDS and Rac/Rho) play a minor, if any, role in the differentiation-defective phenotype of Ras myoblasts. Recently, N...

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Veröffentlicht in:	Oncogene 2001-03, Vol.20 (11), p.1276-1286
Hauptverfasser:	MITIN, Natalia, KUDLA, Arthur J, KONICCZNY, Stephen F, TAPAROWSKY, Elizabeth J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell cycle Cell differentiation Cell physiology Cyclin D1 Fundamental and applied biological sciences. Psychology H-Ras protein MAP kinase Molecular and cellular biology Myoblasts MyoD protein Myogenesis NF-κB protein Phenotypes RelA protein Signal transduction Transcription Tumor necrosis factor-α
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