Antinociceptive effect of spinally injected l-NAME on the acute nociceptive response induced by low concentrations of formalin

The formalin test has been proposed as an animal model of pain produced by tissue injury. Although biphasic nociceptive responses to formalin injection have been well documented, low concentrations (0.125 and 0.5%) of formalin injected into the mouse hindpaw produced only the phasic (acute) paw-lick...

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Veröffentlicht in:	Neurochemistry international 2001-04, Vol.38 (5), p.417-423
Hauptverfasser:	Sakurada, Chikai, Sugiyama, Akinori, Nakayama, Miho, Yonezawa, Akihiko, Sakurada, Shinobu, Tan-No, Koichi, Kisara, Kensuke, Sakurada, Tsukasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute nociception Analgesics - administration & dosage Analgesics - pharmacology Animals Biological and medical sciences Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Formaldehyde - administration & dosage Formalin Fundamental and applied biological sciences. Psychology Injections, Spinal l-NAME Male Mice N-Nitro-L-arginine methyl ester NG-Nitroarginine Methyl Ester - administration & dosage NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide Synthase - antagonists & inhibitors Pain - chemically induced Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Vertebrates: nervous system and sense organs
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