Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography
The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalo...
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| Veröffentlicht in: | Neuroscience letters 2001-02, Vol.298 (3), p.195-198 |
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| container_title | Neuroscience letters |
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| creator | Sörös, Peter Knecht, Stefan Bantel, Carsten Imai, Tanya Wüsten, Rainer Pantev, Christo Lütkenhöner, Bernd Bürkle, Hartmut Henningsen, Henning |
| description | The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites. |
| doi_str_mv | 10.1016/S0304-3940(00)01752-3 |
| format | Article |
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Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(00)01752-3</identifier><identifier>PMID: 11165440</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acute Disease ; Adult ; Biological and medical sciences ; Capsaicin ; Evoked Potentials, Somatosensory - physiology ; Fundamental and applied biological sciences. Psychology ; Hand ; Humans ; Magnetoencephalography ; Male ; Nerve Fibers - physiology ; Neuronal Plasticity - physiology ; Nociceptors - physiology ; Pain ; Pain - chemically induced ; Pain - physiopathology ; Plasticity ; Somatosensory cortex ; Somatosensory Cortex - physiology ; Somatosensory evoked potentials ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2001-02, Vol.298 (3), p.195-198</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-fa5e1b6f394f8138991293bd0bbd43042c956b845e5ca58e4b938f87272fd6383</citedby><cites>FETCH-LOGICAL-c420t-fa5e1b6f394f8138991293bd0bbd43042c956b845e5ca58e4b938f87272fd6383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(00)01752-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=865794$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11165440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sörös, Peter</creatorcontrib><creatorcontrib>Knecht, Stefan</creatorcontrib><creatorcontrib>Bantel, Carsten</creatorcontrib><creatorcontrib>Imai, Tanya</creatorcontrib><creatorcontrib>Wüsten, Rainer</creatorcontrib><creatorcontrib>Pantev, Christo</creatorcontrib><creatorcontrib>Lütkenhöner, Bernd</creatorcontrib><creatorcontrib>Bürkle, Hartmut</creatorcontrib><creatorcontrib>Henningsen, Henning</creatorcontrib><title>Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Capsaicin</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hand</subject><subject>Humans</subject><subject>Magnetoencephalography</subject><subject>Male</subject><subject>Nerve Fibers - physiology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Nociceptors - physiology</subject><subject>Pain</subject><subject>Pain - chemically induced</subject><subject>Pain - physiopathology</subject><subject>Plasticity</subject><subject>Somatosensory cortex</subject><subject>Somatosensory Cortex - physiology</subject><subject>Somatosensory evoked potentials</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFGL1DAQx4Mo3nr6EZSAIPpQTdqkbZ4OOTwVDnxQn8M0nexG2mRNUnH1y5u65XwUAkPCb2by_xHylLPXnPH2zWfWMFE1SrCXjL1ivJN11dwjO953ddWprr5PdnfIBXmU0jfGmORSPCQXnPNWCsF25PfN4k12wcNEI4a4B-9-wfpAg6X5gPSwzODpMboZ4ommMEMOCX0K5WZCzPiTgs0YKZglIz2C83TEOfiUI2Qc6XCiM-w95oDe4PEAU9hHOB5Oj8kDC1PCJ1u9JF9v3n25_lDdfnr_8frtbWVEzXJlQSIfWluC2J43vVK8Vs0wsmEYRUlYGyXboRcSpQHZoxhU09uioavt2DZ9c0lenOceY_i-YMp6dsngNIHHsCTNu14qJboCyjNoYkgpotVbbM2ZXq3rv9b1qlSzclbruil9z7YFyzDj-K9r01yA5xsAycBkI3jj0h3Xt7JTolBXZwqLjB8Oo07Grc5GF9FkPQb3n4_8AamPoR0</recordid><startdate>20010209</startdate><enddate>20010209</enddate><creator>Sörös, Peter</creator><creator>Knecht, Stefan</creator><creator>Bantel, Carsten</creator><creator>Imai, Tanya</creator><creator>Wüsten, Rainer</creator><creator>Pantev, Christo</creator><creator>Lütkenhöner, Bernd</creator><creator>Bürkle, Hartmut</creator><creator>Henningsen, Henning</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20010209</creationdate><title>Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography</title><author>Sörös, Peter ; Knecht, Stefan ; Bantel, Carsten ; Imai, Tanya ; Wüsten, Rainer ; Pantev, Christo ; Lütkenhöner, Bernd ; Bürkle, Hartmut ; Henningsen, Henning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-fa5e1b6f394f8138991293bd0bbd43042c956b845e5ca58e4b938f87272fd6383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Capsaicin</topic><topic>Evoked Potentials, Somatosensory - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hand</topic><topic>Humans</topic><topic>Magnetoencephalography</topic><topic>Male</topic><topic>Nerve Fibers - physiology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Nociceptors - physiology</topic><topic>Pain</topic><topic>Pain - chemically induced</topic><topic>Pain - physiopathology</topic><topic>Plasticity</topic><topic>Somatosensory cortex</topic><topic>Somatosensory Cortex - physiology</topic><topic>Somatosensory evoked potentials</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sörös, Peter</creatorcontrib><creatorcontrib>Knecht, Stefan</creatorcontrib><creatorcontrib>Bantel, Carsten</creatorcontrib><creatorcontrib>Imai, Tanya</creatorcontrib><creatorcontrib>Wüsten, Rainer</creatorcontrib><creatorcontrib>Pantev, Christo</creatorcontrib><creatorcontrib>Lütkenhöner, Bernd</creatorcontrib><creatorcontrib>Bürkle, Hartmut</creatorcontrib><creatorcontrib>Henningsen, Henning</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sörös, Peter</au><au>Knecht, Stefan</au><au>Bantel, Carsten</au><au>Imai, Tanya</au><au>Wüsten, Rainer</au><au>Pantev, Christo</au><au>Lütkenhöner, Bernd</au><au>Bürkle, Hartmut</au><au>Henningsen, Henning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2001-02-09</date><risdate>2001</risdate><volume>298</volume><issue>3</issue><spage>195</spage><epage>198</epage><pages>195-198</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11165440</pmid><doi>10.1016/S0304-3940(00)01752-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2001-02, Vol.298 (3), p.195-198 |
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| subjects | Acute Disease Adult Biological and medical sciences Capsaicin Evoked Potentials, Somatosensory - physiology Fundamental and applied biological sciences. Psychology Hand Humans Magnetoencephalography Male Nerve Fibers - physiology Neuronal Plasticity - physiology Nociceptors - physiology Pain Pain - chemically induced Pain - physiopathology Plasticity Somatosensory cortex Somatosensory Cortex - physiology Somatosensory evoked potentials Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography |
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