Predicting the emergence of antibiotic resistance by directed evolution and structural analysis

Directed evolution can be a powerful tool to predict antibiotic resistance. Resistance involves the accumulation of mutations beneficial to the pathogen while maintaining residue interactions and core packing that are critical for preserving function. The constraint of maintaining stability, while i...

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Veröffentlicht in:	Nature Structural Biology 2001-03, Vol.8 (3), p.238-242
Hauptverfasser:	Orencia, M. Cecilia, Yoon, Jun S., Ness, Jon E., Stemmer, Willem P. C., Stevens, Raymond C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADVANCED LIGHT SOURCE ADVANCED LIGHT SOURCE ALS Amino Acid Sequence Amino Acid Substitution - genetics Antibiotic resistance ANTIBIOTICS beta-Lactamases - chemistry beta-Lactamases - genetics beta-Lactamases - metabolism Binding Sites Biochemistry Biological Microscopy Biomedical and Life Sciences Cefotaxime - pharmacology Crystallography, X-Ray Databases as Topic directed evolution Directed Molecular Evolution Drug Resistance, Microbial - genetics E coli Enzyme Stability - genetics Escherichia coli Escherichia coli - genetics Evolution, Molecular Hydrogen Bonding letter Life Sciences Membrane Biology MICROBIAL DRUG RESISTANCE Models, Molecular Molecular Sequence Data Mutagenesis - genetics Mutation PARTICLE ACCELERATORS Protein Structure Protein Structure, Secondary Protein Structure, Tertiary Selection, Genetic Sequence Alignment Structural analysis Structure-Activity Relationship Suppression, Genetic - genetics Topology
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