Phyllodes tumours of the breast: retrospective analysis of a University Hospital's experience
Taking cognizance of the purported variation of phyllodes tumours in Asians compared with Western populations, this study looked at phyllodes tumours of the breast diagnosed at the Department of Pathology, University of Malaya Medical Centre over an 8-year period with regards to patient profiles, tu...
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| Veröffentlicht in: | Malaysian journal of pathology 2016-04, Vol.38 (1), p.19-24 |
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| creator | Toh, Y F Cheah, P L Looi, L M Teoh, K H Tan, P H |
| description | Taking cognizance of the purported variation of phyllodes tumours in Asians compared with Western populations, this study looked at phyllodes tumours of the breast diagnosed at the Department of Pathology, University of Malaya Medical Centre over an 8-year period with regards to patient profiles, tumour parameters, treatment offered and outcome. Sixty-four new cases of phyllodes tumour were diagnosed during the period, however only 30 (21 benign, 4 borderline and 5 malignant) finally qualified for entry into the study. These were followed-up for 4-102 months (average = 41.7 months). Thirteen cases (8 benign, 3 borderline, 2 malignant) were Chinese, 9 (all benign) Malay, 7 (4 benign, 1 borderline, 2 malignant) Indian and 1 (malignant) Indonesian. Prevalence of benign versus combined borderline and malignant phyllodes showed a marginally significant difference (p=0.049) between the Malays and Chinese. Patients' ages ranged from 21-70 years with a mean of 44.9 years with no significant difference in age between benign, borderline or malignant phyllodes tumours. Except for benign phyllodes tumours (mean size = 5.8 cm) being significantly smaller at presentation compared with borderline (mean size = 12.5 cm) and malignant (mean size = 15.8 cm) (p |
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Sixty-four new cases of phyllodes tumour were diagnosed during the period, however only 30 (21 benign, 4 borderline and 5 malignant) finally qualified for entry into the study. These were followed-up for 4-102 months (average = 41.7 months). Thirteen cases (8 benign, 3 borderline, 2 malignant) were Chinese, 9 (all benign) Malay, 7 (4 benign, 1 borderline, 2 malignant) Indian and 1 (malignant) Indonesian. Prevalence of benign versus combined borderline and malignant phyllodes showed a marginally significant difference (p=0.049) between the Malays and Chinese. Patients' ages ranged from 21-70 years with a mean of 44.9 years with no significant difference in age between benign, borderline or malignant phyllodes tumours. Except for benign phyllodes tumours (mean size = 5.8 cm) being significantly smaller at presentation compared with borderline (mean size = 12.5 cm) and malignant (mean size = 15.8 cm) (p<0.05) tumours, history of previous pregnancy, breast feeding, hormonal contraception and tumour laterality did not differ between the three categories. Family history of breast cancer was noted in 2 cases of benign phyllodes. Local excision was performed in 17 benign, 2 borderline and 3 malignant tumours and mastectomy in 4 benign, 2 borderline and 2 malignant tumours. Surgical clearance was not properly recorded in 10 benign phyllodes tumours. Six benign and all 4 borderline and 5 malignant tumours had clearances of <10 mm. Two benign tumours recurred locally at 15 and 49 months after local excision, however information regarding surgical clearance was not available in both cases. One patient with a malignant tumour developed a radiologically-diagnosed lung nodule 26 months after mastectomy, was given a course of radiotherapy and remained well 8-months following identification of the lung nodule.</description><identifier>ISSN: 0126-8635</identifier><identifier>PMID: 27126660</identifier><language>eng</language><publisher>Malaysia: College of Pathologists, Academy of Medicine of Malaysia</publisher><subject>Adult ; Aged ; Breast Neoplasms - ethnology ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Female ; Hospitals, University ; Humans ; Lung Neoplasms - radiotherapy ; Lung Neoplasms - secondary ; Mastectomy ; Middle Aged ; Neoplasm, Residual ; Phyllodes Tumor - ethnology ; Phyllodes Tumor - pathology ; Phyllodes Tumor - radiotherapy ; Phyllodes Tumor - secondary ; Phyllodes Tumor - surgery ; Prevalence ; Retrospective Studies ; Risk Factors ; Singapore - epidemiology ; Time Factors ; Treatment Outcome ; Tumor Burden ; Young Adult</subject><ispartof>Malaysian journal of pathology, 2016-04, Vol.38 (1), p.19-24</ispartof><rights>Copyright College of Pathologists, Academy of Medicine of Malaysia Apr 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27126660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toh, Y F</creatorcontrib><creatorcontrib>Cheah, P L</creatorcontrib><creatorcontrib>Looi, L M</creatorcontrib><creatorcontrib>Teoh, K H</creatorcontrib><creatorcontrib>Tan, P H</creatorcontrib><title>Phyllodes tumours of the breast: retrospective analysis of a University Hospital's experience</title><title>Malaysian journal of pathology</title><addtitle>Malays J Pathol</addtitle><description>Taking cognizance of the purported variation of phyllodes tumours in Asians compared with Western populations, this study looked at phyllodes tumours of the breast diagnosed at the Department of Pathology, University of Malaya Medical Centre over an 8-year period with regards to patient profiles, tumour parameters, treatment offered and outcome. Sixty-four new cases of phyllodes tumour were diagnosed during the period, however only 30 (21 benign, 4 borderline and 5 malignant) finally qualified for entry into the study. These were followed-up for 4-102 months (average = 41.7 months). Thirteen cases (8 benign, 3 borderline, 2 malignant) were Chinese, 9 (all benign) Malay, 7 (4 benign, 1 borderline, 2 malignant) Indian and 1 (malignant) Indonesian. Prevalence of benign versus combined borderline and malignant phyllodes showed a marginally significant difference (p=0.049) between the Malays and Chinese. Patients' ages ranged from 21-70 years with a mean of 44.9 years with no significant difference in age between benign, borderline or malignant phyllodes tumours. Except for benign phyllodes tumours (mean size = 5.8 cm) being significantly smaller at presentation compared with borderline (mean size = 12.5 cm) and malignant (mean size = 15.8 cm) (p<0.05) tumours, history of previous pregnancy, breast feeding, hormonal contraception and tumour laterality did not differ between the three categories. Family history of breast cancer was noted in 2 cases of benign phyllodes. Local excision was performed in 17 benign, 2 borderline and 3 malignant tumours and mastectomy in 4 benign, 2 borderline and 2 malignant tumours. Surgical clearance was not properly recorded in 10 benign phyllodes tumours. Six benign and all 4 borderline and 5 malignant tumours had clearances of <10 mm. Two benign tumours recurred locally at 15 and 49 months after local excision, however information regarding surgical clearance was not available in both cases. One patient with a malignant tumour developed a radiologically-diagnosed lung nodule 26 months after mastectomy, was given a course of radiotherapy and remained well 8-months following identification of the lung nodule.</description><subject>Adult</subject><subject>Aged</subject><subject>Breast Neoplasms - ethnology</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Female</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Lung Neoplasms - radiotherapy</subject><subject>Lung Neoplasms - secondary</subject><subject>Mastectomy</subject><subject>Middle Aged</subject><subject>Neoplasm, Residual</subject><subject>Phyllodes Tumor - ethnology</subject><subject>Phyllodes Tumor - pathology</subject><subject>Phyllodes Tumor - radiotherapy</subject><subject>Phyllodes Tumor - secondary</subject><subject>Phyllodes Tumor - surgery</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Singapore - epidemiology</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumor Burden</subject><subject>Young Adult</subject><issn>0126-8635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0E1LxDAQBuAeFHdd_QsS8KCXQr6aJt5kUVdY0IN7lJKmUzZL-mGSiv33Bl0vngZmHl545yRbYkJFLgUrFtl5CAeMBVdKnmULWqaLEHiZvb_uZ-eGBgKKUzdMPqChRXEPqPagQ7xDHqIfwggm2k9AutduDvZHabTr084HG2e0ScZG7W4Cgq8RvIXewEV22moX4PI4V9nu8eFtvcm3L0_P6_ttPlKmYg41MaIlZauoaTQHwLLhSlPMC94oQ1pOcSEkFjWDogAhpCgZI0BqoyXhwFbZ7W_u6IePCUKsOhsMOKd7GKZQkVIWJVeSk0Sv_9FDap1aJSUx4ZIqgpO6Oqqp7qCpRm877efq73HsG2n1aQc</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Toh, Y F</creator><creator>Cheah, P L</creator><creator>Looi, L M</creator><creator>Teoh, K H</creator><creator>Tan, P H</creator><general>College of Pathologists, Academy of Medicine of Malaysia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>Phyllodes tumours of the breast: retrospective analysis of a University Hospital's experience</title><author>Toh, Y F ; Cheah, P L ; Looi, L M ; Teoh, K H ; Tan, P H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-eb1c6f17f92cda4ee08d49a20454d9c1f42056806b3e55e66867331e1bca814e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Breast Neoplasms - ethnology</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Female</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Lung Neoplasms - radiotherapy</topic><topic>Lung Neoplasms - secondary</topic><topic>Mastectomy</topic><topic>Middle Aged</topic><topic>Neoplasm, Residual</topic><topic>Phyllodes Tumor - ethnology</topic><topic>Phyllodes Tumor - pathology</topic><topic>Phyllodes Tumor - radiotherapy</topic><topic>Phyllodes Tumor - secondary</topic><topic>Phyllodes Tumor - surgery</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Singapore - epidemiology</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumor Burden</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toh, Y F</creatorcontrib><creatorcontrib>Cheah, P L</creatorcontrib><creatorcontrib>Looi, L M</creatorcontrib><creatorcontrib>Teoh, K H</creatorcontrib><creatorcontrib>Tan, P H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Malaysian journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toh, Y F</au><au>Cheah, P L</au><au>Looi, L M</au><au>Teoh, K H</au><au>Tan, P H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phyllodes tumours of the breast: retrospective analysis of a University Hospital's experience</atitle><jtitle>Malaysian journal of pathology</jtitle><addtitle>Malays J Pathol</addtitle><date>2016-04</date><risdate>2016</risdate><volume>38</volume><issue>1</issue><spage>19</spage><epage>24</epage><pages>19-24</pages><issn>0126-8635</issn><abstract>Taking cognizance of the purported variation of phyllodes tumours in Asians compared with Western populations, this study looked at phyllodes tumours of the breast diagnosed at the Department of Pathology, University of Malaya Medical Centre over an 8-year period with regards to patient profiles, tumour parameters, treatment offered and outcome. Sixty-four new cases of phyllodes tumour were diagnosed during the period, however only 30 (21 benign, 4 borderline and 5 malignant) finally qualified for entry into the study. These were followed-up for 4-102 months (average = 41.7 months). Thirteen cases (8 benign, 3 borderline, 2 malignant) were Chinese, 9 (all benign) Malay, 7 (4 benign, 1 borderline, 2 malignant) Indian and 1 (malignant) Indonesian. Prevalence of benign versus combined borderline and malignant phyllodes showed a marginally significant difference (p=0.049) between the Malays and Chinese. Patients' ages ranged from 21-70 years with a mean of 44.9 years with no significant difference in age between benign, borderline or malignant phyllodes tumours. Except for benign phyllodes tumours (mean size = 5.8 cm) being significantly smaller at presentation compared with borderline (mean size = 12.5 cm) and malignant (mean size = 15.8 cm) (p<0.05) tumours, history of previous pregnancy, breast feeding, hormonal contraception and tumour laterality did not differ between the three categories. Family history of breast cancer was noted in 2 cases of benign phyllodes. Local excision was performed in 17 benign, 2 borderline and 3 malignant tumours and mastectomy in 4 benign, 2 borderline and 2 malignant tumours. Surgical clearance was not properly recorded in 10 benign phyllodes tumours. Six benign and all 4 borderline and 5 malignant tumours had clearances of <10 mm. Two benign tumours recurred locally at 15 and 49 months after local excision, however information regarding surgical clearance was not available in both cases. One patient with a malignant tumour developed a radiologically-diagnosed lung nodule 26 months after mastectomy, was given a course of radiotherapy and remained well 8-months following identification of the lung nodule.</abstract><cop>Malaysia</cop><pub>College of Pathologists, Academy of Medicine of Malaysia</pub><pmid>27126660</pmid><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Breast Neoplasms - ethnology Breast Neoplasms - pathology Breast Neoplasms - surgery Female Hospitals, University Humans Lung Neoplasms - radiotherapy Lung Neoplasms - secondary Mastectomy Middle Aged Neoplasm, Residual Phyllodes Tumor - ethnology Phyllodes Tumor - pathology Phyllodes Tumor - radiotherapy Phyllodes Tumor - secondary Phyllodes Tumor - surgery Prevalence Retrospective Studies Risk Factors Singapore - epidemiology Time Factors Treatment Outcome Tumor Burden Young Adult |
| title | Phyllodes tumours of the breast: retrospective analysis of a University Hospital's experience |
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