Formation of Benzylic−DNA Adducts Resulting from 7,12-Dimethylbenz[a]anthracene in Vivo

Studies were undertaken to determine the formation of benzylic−DNA adducts in rats administered 7,12-dimethylbenz[a]anthracene (DMBA) and its meso-region metabolites by subcutaneous injection. Here, we show that 7-hydroxymethyl-12-methylbenz[a]anthracene (7-HMBA) and 7-sulfoxymethyl-12-methylbenz[a]...

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Veröffentlicht in:	Chemical research in toxicology 2005-04, Vol.18 (4), p.686-691
Hauptverfasser:	Ravi Kumar, M. N. V, Vadhanam, Manicka V, Horn, Jamie, Flesher, James W, Gupta, Ramesh C
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene - metabolism Animals Chromatography, Thin Layer DNA Adducts - metabolism Female Rats Rats, Sprague-Dawley Skin - metabolism
Online-Zugang:	Volltext
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