Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κB Pathways

OBJECTIVE—Restenosis after percutaneous coronary intervention remains to be a serious medical problem. Although mineralocorticoid receptor (MR) has been implicated as a potential target for treating restenosis, the cellular and molecular mechanisms are largely unknown. This study aims to explore the...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2016-05, Vol.36 (5), p.874-885
Hauptverfasser:	Sun, Jian-Yong, Li, Chao, Shen, Zhu-Xia, Zhang, Wu-Chang, Ai, Tang-Jun, Du, Lin-Juan, Zhang, Yu-Yao, Yao, Gao-Feng, Liu, Yan, Sun, Shuyang, Naray-Fejes-Toth, Aniko, Fejes-Toth, Geza, Peng, Yong, Chen, Mao, Liu, Xiaojing, Tao, Jun, Zhou, Bin, Yu, Ying, Guo, Feifan, Du, Jie, Duan, Sheng-Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Cell Proliferation Coculture Techniques Disease Models, Animal Femoral Artery - enzymology Femoral Artery - injuries Femoral Artery - metabolism Genetic Predisposition to Disease Hyperplasia Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Inflammation - enzymology Inflammation - genetics Inflammation - pathology Inflammation - prevention & control Macrophages - enzymology Male Mice Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - injuries Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - enzymology Myocytes, Smooth Muscle - pathology Neointima NF-kappa B - metabolism Paracrine Communication Phenotype Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RAW 264.7 Cells Receptors, Mineralocorticoid - deficiency Receptors, Mineralocorticoid - genetics RNA Interference Signal Transduction Time Factors Transcription Factor AP-1 - metabolism Transfection Vascular Remodeling Vascular System Injuries - enzymology Vascular System Injuries - genetics Vascular System Injuries - pathology Vascular System Injuries - prevention & control
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