Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects

Objective: The aim of present investigation was to prepare Curcumin-Zn(II) complex in a view to enhance solubility, stability and pharmacodynamic effect in experimentally induced ulcerative colitis. Method: Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a m...

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Veröffentlicht in:	Pharmaceutical development and technology 2016-08, Vol.21 (5), p.630-635
Hauptverfasser:	Sareen, Rashmi, Jain, Nitin, Dhar, K. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Colitis Colitis, Ulcerative - drug therapy Colitis, Ulcerative - pathology curcumin Curcumin - administration & dosage Curcumin - chemistry Curcumin - pharmacokinetics curcumin-Zn(II) Drug Delivery Systems - methods Drug Stability Mice pharmacodynamic effect solubility Solubility - drug effects stability Zinc - administration & dosage Zinc - chemistry Zinc - pharmacokinetics
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