Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects
Objective: The aim of present investigation was to prepare Curcumin-Zn(II) complex in a view to enhance solubility, stability and pharmacodynamic effect in experimentally induced ulcerative colitis. Method: Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a m...
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| Veröffentlicht in: | Pharmaceutical development and technology 2016-08, Vol.21 (5), p.630-635 |
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| creator | Sareen, Rashmi Jain, Nitin Dhar, K. L. |
| description | Objective: The aim of present investigation was to prepare Curcumin-Zn(II) complex in a view to enhance solubility, stability and pharmacodynamic effect in experimentally induced ulcerative colitis.
Method: Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a molar ratio of 1:1. The prepared curcumin metallocomplex was characterized by TLC, FTIR, UV spectroscopy and
1
H NMR. In vitro kinetic degradation and solubility of Curcumin and Curcumin-Zn(II) complex was analyzed spectrophotometrically. Pharmacodynamic evaluation of curcumin and its metal complex was assessed in ulcerative colitis in mice.
Results: Curcumin showed chelation with zinc ion as confirmed by the TLC, FTIR, UV spectroscopy and
1
H NMR. The results of TLC [R
f
value], IR Spectroscopy [shifting of stretching vibrations of υ(C=C) and υ(C=O)], UV spectra [deconvoluted with absorption band at 432-466.4 nm] of Curcumin-Zn(II) complex compared to curcumin confirmed the formation of metallocomplex.
1
HNMR spectra of Curcumin-Zn(II) showed the upfield shift of H
a
and H
b
. Kinetic stability studies showed metallocomplex with zinc exhibited good stability. In vivo study revealed significant reduction in severity and extent of colonic damage with Curcumin-Zn(II) which were further confirmed by histopathological study.
Conclusion: This study recognizes higher solubility and stability of Curcumin-Zn(II) complex and suggested better pharmacodynamic effects. |
| doi_str_mv | 10.3109/10837450.2015.1041042 |
| format | Article |
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Method: Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a molar ratio of 1:1. The prepared curcumin metallocomplex was characterized by TLC, FTIR, UV spectroscopy and
1
H NMR. In vitro kinetic degradation and solubility of Curcumin and Curcumin-Zn(II) complex was analyzed spectrophotometrically. Pharmacodynamic evaluation of curcumin and its metal complex was assessed in ulcerative colitis in mice.
Results: Curcumin showed chelation with zinc ion as confirmed by the TLC, FTIR, UV spectroscopy and
1
H NMR. The results of TLC [R
f
value], IR Spectroscopy [shifting of stretching vibrations of υ(C=C) and υ(C=O)], UV spectra [deconvoluted with absorption band at 432-466.4 nm] of Curcumin-Zn(II) complex compared to curcumin confirmed the formation of metallocomplex.
1
HNMR spectra of Curcumin-Zn(II) showed the upfield shift of H
a
and H
b
. Kinetic stability studies showed metallocomplex with zinc exhibited good stability. In vivo study revealed significant reduction in severity and extent of colonic damage with Curcumin-Zn(II) which were further confirmed by histopathological study.
Conclusion: This study recognizes higher solubility and stability of Curcumin-Zn(II) complex and suggested better pharmacodynamic effects.</description><identifier>ISSN: 1083-7450</identifier><identifier>EISSN: 1097-9867</identifier><identifier>DOI: 10.3109/10837450.2015.1041042</identifier><identifier>PMID: 25923136</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Colitis ; Colitis, Ulcerative - drug therapy ; Colitis, Ulcerative - pathology ; curcumin ; Curcumin - administration & dosage ; Curcumin - chemistry ; Curcumin - pharmacokinetics ; curcumin-Zn(II) ; Drug Delivery Systems - methods ; Drug Stability ; Mice ; pharmacodynamic effect ; solubility ; Solubility - drug effects ; stability ; Zinc - administration & dosage ; Zinc - chemistry ; Zinc - pharmacokinetics</subject><ispartof>Pharmaceutical development and technology, 2016-08, Vol.21 (5), p.630-635</ispartof><rights>2015 Taylor & Francis. 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-902b95a155cade09fdc1eb46112fe352b55e76507802b5ca2349705c74fae4613</citedby><cites>FETCH-LOGICAL-c366t-902b95a155cade09fdc1eb46112fe352b55e76507802b5ca2349705c74fae4613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25923136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sareen, Rashmi</creatorcontrib><creatorcontrib>Jain, Nitin</creatorcontrib><creatorcontrib>Dhar, K. L.</creatorcontrib><title>Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects</title><title>Pharmaceutical development and technology</title><addtitle>Pharm Dev Technol</addtitle><description>Objective: The aim of present investigation was to prepare Curcumin-Zn(II) complex in a view to enhance solubility, stability and pharmacodynamic effect in experimentally induced ulcerative colitis.
Method: Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a molar ratio of 1:1. The prepared curcumin metallocomplex was characterized by TLC, FTIR, UV spectroscopy and
1
H NMR. In vitro kinetic degradation and solubility of Curcumin and Curcumin-Zn(II) complex was analyzed spectrophotometrically. Pharmacodynamic evaluation of curcumin and its metal complex was assessed in ulcerative colitis in mice.
Results: Curcumin showed chelation with zinc ion as confirmed by the TLC, FTIR, UV spectroscopy and
1
H NMR. The results of TLC [R
f
value], IR Spectroscopy [shifting of stretching vibrations of υ(C=C) and υ(C=O)], UV spectra [deconvoluted with absorption band at 432-466.4 nm] of Curcumin-Zn(II) complex compared to curcumin confirmed the formation of metallocomplex.
1
HNMR spectra of Curcumin-Zn(II) showed the upfield shift of H
a
and H
b
. Kinetic stability studies showed metallocomplex with zinc exhibited good stability. In vivo study revealed significant reduction in severity and extent of colonic damage with Curcumin-Zn(II) which were further confirmed by histopathological study.
Conclusion: This study recognizes higher solubility and stability of Curcumin-Zn(II) complex and suggested better pharmacodynamic effects.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>Colitis</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Colitis, Ulcerative - pathology</subject><subject>curcumin</subject><subject>Curcumin - administration & dosage</subject><subject>Curcumin - chemistry</subject><subject>Curcumin - pharmacokinetics</subject><subject>curcumin-Zn(II)</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Stability</subject><subject>Mice</subject><subject>pharmacodynamic effect</subject><subject>solubility</subject><subject>Solubility - drug effects</subject><subject>stability</subject><subject>Zinc - administration & dosage</subject><subject>Zinc - chemistry</subject><subject>Zinc - pharmacokinetics</subject><issn>1083-7450</issn><issn>1097-9867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u3CAURlGVqJOkfYRGXqYLT8AYY3eVaNSfkUbKJt10gzC-aIjAuGAnHSkPH1xPsoyEBJ843wUdhL4QvKYEN9cE15SXDK8LTNia4DKt4gM6S3c8b-qKn8znmuYztELnMT5gTOoGs49oVbCmoIRWZ-h5MwU1OdPnf_qr7fZrprwbLPzLtA8Z9HvZK-iy6O3UGmvGQyb7FEe5pG8pZnIYgpdq_79iXAqPqdKBNY8QlsKwl8FJ5btDL51RGWgNaoyf0KmWNsLn436Bfv_4fr_5le_ufm43t7tc0aoa8wYXbcMkYUzJDnCjO0WgLStCCg2UFS1jwCuGeZ3AxBS0bDhmipdaQsLoBbpa5qa__Z0gjsKZqMBa2YOfoiC8ZpxWSVRC2YKq4GMMoMUQjJPhIAgWs3jxKl7M4sVRfOpdHp-YWgfdW-vVdAJuFsD0yZOTTz7YTozyYH3QIWk2cZ7_3hsv5jeTTA</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Sareen, Rashmi</creator><creator>Jain, Nitin</creator><creator>Dhar, K. L.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects</title><author>Sareen, Rashmi ; Jain, Nitin ; Dhar, K. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-902b95a155cade09fdc1eb46112fe352b55e76507802b5ca2349705c74fae4613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>Colitis</topic><topic>Colitis, Ulcerative - drug therapy</topic><topic>Colitis, Ulcerative - pathology</topic><topic>curcumin</topic><topic>Curcumin - administration & dosage</topic><topic>Curcumin - chemistry</topic><topic>Curcumin - pharmacokinetics</topic><topic>curcumin-Zn(II)</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Stability</topic><topic>Mice</topic><topic>pharmacodynamic effect</topic><topic>solubility</topic><topic>Solubility - drug effects</topic><topic>stability</topic><topic>Zinc - administration & dosage</topic><topic>Zinc - chemistry</topic><topic>Zinc - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sareen, Rashmi</creatorcontrib><creatorcontrib>Jain, Nitin</creatorcontrib><creatorcontrib>Dhar, K. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical development and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sareen, Rashmi</au><au>Jain, Nitin</au><au>Dhar, K. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects</atitle><jtitle>Pharmaceutical development and technology</jtitle><addtitle>Pharm Dev Technol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>21</volume><issue>5</issue><spage>630</spage><epage>635</epage><pages>630-635</pages><issn>1083-7450</issn><eissn>1097-9867</eissn><abstract>Objective: The aim of present investigation was to prepare Curcumin-Zn(II) complex in a view to enhance solubility, stability and pharmacodynamic effect in experimentally induced ulcerative colitis.
Method: Curcumin-Zn(II) complex was prepared by stirring curcumin with anhydrous zinc chloride at a molar ratio of 1:1. The prepared curcumin metallocomplex was characterized by TLC, FTIR, UV spectroscopy and
1
H NMR. In vitro kinetic degradation and solubility of Curcumin and Curcumin-Zn(II) complex was analyzed spectrophotometrically. Pharmacodynamic evaluation of curcumin and its metal complex was assessed in ulcerative colitis in mice.
Results: Curcumin showed chelation with zinc ion as confirmed by the TLC, FTIR, UV spectroscopy and
1
H NMR. The results of TLC [R
f
value], IR Spectroscopy [shifting of stretching vibrations of υ(C=C) and υ(C=O)], UV spectra [deconvoluted with absorption band at 432-466.4 nm] of Curcumin-Zn(II) complex compared to curcumin confirmed the formation of metallocomplex.
1
HNMR spectra of Curcumin-Zn(II) showed the upfield shift of H
a
and H
b
. Kinetic stability studies showed metallocomplex with zinc exhibited good stability. In vivo study revealed significant reduction in severity and extent of colonic damage with Curcumin-Zn(II) which were further confirmed by histopathological study.
Conclusion: This study recognizes higher solubility and stability of Curcumin-Zn(II) complex and suggested better pharmacodynamic effects.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>25923136</pmid><doi>10.3109/10837450.2015.1041042</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Colitis Colitis, Ulcerative - drug therapy Colitis, Ulcerative - pathology curcumin Curcumin - administration & dosage Curcumin - chemistry Curcumin - pharmacokinetics curcumin-Zn(II) Drug Delivery Systems - methods Drug Stability Mice pharmacodynamic effect solubility Solubility - drug effects stability Zinc - administration & dosage Zinc - chemistry Zinc - pharmacokinetics |
| title | Curcumin-Zn(II) complex for enhanced solubility and stability: an approach for improved delivery and pharmacodynamic effects |
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