Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium

The goal of our studies is to elucidate mechanisms that control and modulate mucous differentiation and mucin gene expression in the conducting airways. We used cultures of normal human tracheobronchial epithelial (NHTBE) cells that were shown to secrete two major airway mucins, namely MUC5AC and MU...

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Veröffentlicht in:	Toxicology (Amsterdam) 2001-03, Vol.160 (1), p.35-46
Hauptverfasser:	Gray, Thomas, Koo, Ja-Seok, Nettesheim, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Bronchi - cytology Bronchi - drug effects Bronchi - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line Cell physiology Dose-Response Relationship, Drug Drug Interactions Epidermal Growth Factor - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Humans Miscellaneous Molecular and cellular biology Mucin gene expression mucins Mucins - genetics Mucins - metabolism Mucous differentiation Receptors, Retinoic Acid - metabolism Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Trachea - cytology Trachea - drug effects Trachea - metabolism Tracheobronchial epithelium Tretinoin - pharmacology Triiodothyronine - pharmacology
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