Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors

Eosinophil-derived neurotoxin (EDN), a basic ribonuclease found in the large specific granules of eosinophils, belongs to the pancreatic RNase A family. Although its physiological function is still unclear, it has been shown that EDN is a neurotoxin capable of inducing the Gordon phenomenon in rabbi...

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Veröffentlicht in:	The Journal of biological chemistry 2001-05, Vol.276 (18), p.15009-15017
Hauptverfasser:	Leonidas, D D, Boix, E, Prill, R, Suzuki, M, Turton, R, Minson, K, Swaminathan, G J, Youle, R J, Acharya, K R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism ADP Binding Sites Crystallography, X-Ray Eosinophil-Derived Neurotoxin Gordon phenomenon Models, Molecular Protein Binding Protein Conformation Recombinant Proteins - genetics Recombinant Proteins - metabolism ribonuclease Ribonuclease, Pancreatic - metabolism Ribonucleases - chemistry Ribonucleases - metabolism
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