Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion

Caveolin-1 (Cav-1) is the principal structural component of caveolae membrane domains in non-muscle cells, including mammary epithelia. There is now clear evidence that caveolin-1 influences the development of human cancers. For example, a dominant-negative mutation (P132L) in the Cav-1 gene has bee...

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (49), p.51630-51646
Hauptverfasser:	Williams, Terence M, Medina, Freddy, Badano, Ines, Hazan, Rachel B, Hutchinson, John, Muller, William J, Chopra, Neeru G, Scherer, Philipp E, Pestell, Richard G, Lisanti, Michael P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caveolin 1 Caveolins - genetics Cell Line, Tumor Cell Membrane - metabolism Cell Movement Cells, Cultured Collagen - pharmacology Cyclin D1 - biosynthesis Disease Progression Drug Combinations Electrophoresis, Polyacrylamide Gel Enzyme Activation Female Gene Expression Regulation, Neoplastic Immunoblotting Inhibitory Concentration 50 Laminin - pharmacology Lung Neoplasms - secondary Male Mammary Neoplasms, Animal - genetics Mammary Tumor Virus, Mouse - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Mice, Transgenic Microscopy, Fluorescence Mitogen-Activated Protein Kinase 1 - biosynthesis Mitogen-Activated Protein Kinase 3 - biosynthesis Mutation Neoplasm Invasiveness Neoplasm Metastasis - genetics Peptides - chemistry Phosphorylation Proteoglycans - pharmacology Recombinant Proteins - metabolism Retinoblastoma Protein - metabolism Retroviridae - genetics Time Factors Up-Regulation
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