Preconditioning of H2S inhalation protects against cerebral ischemia/reperfusion injury by induction of HSP70 through PI3K/Akt/Nrf2 pathway

•H2S preconditioning exhibited significant neuroprotection against cerebral I/R.•The protective effect of H2S preconditioning involves heat shock protein 70 (HSP70).•HSP70 protects mice against cerebral I/R through PI3K/Akt/Nrf2 pathway. It is of great importance to protect the brain against cerebra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2016-03, Vol.121, p.68-74
Hauptverfasser:	Ji, Kangxiang, Xue, Long, Cheng, Jiwei, Bai, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Akt Animals Brain Infarction - etiology Brain Infarction - prevention & control Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Disease Models, Animal Enzyme Inhibitors - pharmacology H2S HSP70 HSP70 Heat-Shock Proteins - metabolism Hydrogen Sulfide - administration & dosage Hydrogen Sulfide - pharmacology Interleukin-6 - metabolism Ischemia-reperfusion Male Malondialdehyde - metabolism Maze Learning - physiology Maze Learning - radiation effects Mice Mice, Inbred C57BL Mice, Transgenic Neurologic Examination NF-E2-Related Factor 2 - deficiency NF-E2-Related Factor 2 - genetics Nrf2 Oncogene Protein v-akt - metabolism Phosphatidylinositol 3-Kinases - metabolism PI3K Reperfusion Injury - metabolism Reperfusion Injury - prevention & control Signal Transduction - drug effects Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!