Affinity capture elution bridging assay: A novel immunoassay format for detection of anti-therapeutic protein antibodies

Increased emphasis on the development of biologics has placed a significant focus on anti-drug antibody (ADA) detection. To address this need, several immunoassay formats have been described for use in characterizing potential immune responses. Two commonly utilized methods include the affinity capt...

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Veröffentlicht in:	Journal of immunological methods 2016-04, Vol.431, p.45-51
Hauptverfasser:	Chen, Yan Q., Pottanat, Thomas G., Carter, Quincy L., Troutt, Jason S., Konrad, Robert J., Sloan, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - blood Antibodies - immunology Bridging anti-therapeutic monoclonal antibody assay Drug tolerance Humans Immunoassay - methods Immunogenicity MesoScale Discovery Proteins - immunology Proteins - therapeutic use
Online-Zugang:	Volltext
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