Hypopituitarism patterns among adult males with prolactinomas
•A large cohort of male patients with prolactinomas were studied.•A larger cohort may have led to more statistically significant results in the study.•Recovery from visual field defects and hypopituitarism was noted in most of the patients.•Our study provides better insight into hypopituitarism patt...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2016-05, Vol.144, p.112-118 |
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| creator | Peng, Junxiang Qiu, Mingxing Qi, Songtao Li, Danling Peng, Yuping |
| description | •A large cohort of male patients with prolactinomas were studied.•A larger cohort may have led to more statistically significant results in the study.•Recovery from visual field defects and hypopituitarism was noted in most of the patients.•Our study provides better insight into hypopituitarism patterns in these patients.•The adenoma size is correlated with the prevalence of pituitary hormone dysfunction.
The objective of this study was to characterize hypopituitarism in adult males with prolactinomas.
We retrospectively analyzed the records of 102 consecutive patients, classified under three categories based on adenoma size at diagnosis: 1.0–2.0cm (group A), 2.1–4.0cm (group B), and >4.0cm (group C). Further, 76 patients had successful outcomes at follow-up. We compared different forms of pituitary hormone dysfunction (growth hormone deficiency, hypogonadism, hypothyroidism, and hypocortisolism) based on the maximal adenoma diameter.
Serum prolactin levels were significantly correlated with the maximal adenoma diameter (r=0.867; P=0.000). Of the patients, 89.2% presented with pituitary failure, which included 74.5% with growth hormone deficiency, 71.6% with hypogonadism, 28.4% with hypothyroidism, and 12.7% with hypocortisolism. The three groups did not differ significantly (P>0.05) in the incidence of hypopituitarism, including the extent of pituitary axis deficiency, at presentation and following treatment. However, there was a statistically significant difference in the degree of hypogonadism in cases of acquired pituitary insufficiency at diagnosis (P=0.000).
In adult males with prolactin-secreting adenomas, the most common form of pituitary hormone dysfunction was growth hormone deficiency and hypogonadism, whereas hypocortisolism was less common. The maximal adenoma diameter and prolactin secretion did not determine hormone insufficiency in adult males with prolactinomas, but these factors did affect the degree of both hypogonadism and hypothyroidism. Smaller tumors were found to recur more frequently than large tumors, and recovery was more common in cases of growth hormone deficiency and hypogonadism. |
| doi_str_mv | 10.1016/j.clineuro.2016.01.029 |
| format | Article |
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The objective of this study was to characterize hypopituitarism in adult males with prolactinomas.
We retrospectively analyzed the records of 102 consecutive patients, classified under three categories based on adenoma size at diagnosis: 1.0–2.0cm (group A), 2.1–4.0cm (group B), and >4.0cm (group C). Further, 76 patients had successful outcomes at follow-up. We compared different forms of pituitary hormone dysfunction (growth hormone deficiency, hypogonadism, hypothyroidism, and hypocortisolism) based on the maximal adenoma diameter.
Serum prolactin levels were significantly correlated with the maximal adenoma diameter (r=0.867; P=0.000). Of the patients, 89.2% presented with pituitary failure, which included 74.5% with growth hormone deficiency, 71.6% with hypogonadism, 28.4% with hypothyroidism, and 12.7% with hypocortisolism. The three groups did not differ significantly (P>0.05) in the incidence of hypopituitarism, including the extent of pituitary axis deficiency, at presentation and following treatment. However, there was a statistically significant difference in the degree of hypogonadism in cases of acquired pituitary insufficiency at diagnosis (P=0.000).
In adult males with prolactin-secreting adenomas, the most common form of pituitary hormone dysfunction was growth hormone deficiency and hypogonadism, whereas hypocortisolism was less common. The maximal adenoma diameter and prolactin secretion did not determine hormone insufficiency in adult males with prolactinomas, but these factors did affect the degree of both hypogonadism and hypothyroidism. Smaller tumors were found to recur more frequently than large tumors, and recovery was more common in cases of growth hormone deficiency and hypogonadism.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2016.01.029</identifier><identifier>PMID: 27038873</identifier><identifier>CODEN: CNNSBV</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Adult male ; Cohort Studies ; Follow-Up Studies ; Humans ; Hypopituitarism ; Hypopituitarism - blood ; Hypopituitarism - diagnostic imaging ; Hypothyroidism ; Insulin-like growth factors ; Laboratories ; Magnetic Resonance Imaging ; Male ; Males ; Medical imaging ; Middle Aged ; Mortality ; Neurology ; NMR ; Nuclear magnetic resonance ; Pituitary ; Pituitary gland ; Pituitary Neoplasms - blood ; Pituitary Neoplasms - diagnostic imaging ; Prolactin - blood ; Prolactinoma ; Prolactinoma - blood ; Prolactinoma - diagnostic imaging ; Retrospective Studies ; Statistical analysis ; Studies ; Tumors ; Variables ; Variance analysis</subject><ispartof>Clinical neurology and neurosurgery, 2016-05, Vol.144, p.112-118</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-190f608b1016b20977c6a90b21fd3d855e2be78fa2e4d7e7ea2afd804daccb513</citedby><cites>FETCH-LOGICAL-c429t-190f608b1016b20977c6a90b21fd3d855e2be78fa2e4d7e7ea2afd804daccb513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1780706974?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27038873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Junxiang</creatorcontrib><creatorcontrib>Qiu, Mingxing</creatorcontrib><creatorcontrib>Qi, Songtao</creatorcontrib><creatorcontrib>Li, Danling</creatorcontrib><creatorcontrib>Peng, Yuping</creatorcontrib><title>Hypopituitarism patterns among adult males with prolactinomas</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>•A large cohort of male patients with prolactinomas were studied.•A larger cohort may have led to more statistically significant results in the study.•Recovery from visual field defects and hypopituitarism was noted in most of the patients.•Our study provides better insight into hypopituitarism patterns in these patients.•The adenoma size is correlated with the prevalence of pituitary hormone dysfunction.
The objective of this study was to characterize hypopituitarism in adult males with prolactinomas.
We retrospectively analyzed the records of 102 consecutive patients, classified under three categories based on adenoma size at diagnosis: 1.0–2.0cm (group A), 2.1–4.0cm (group B), and >4.0cm (group C). Further, 76 patients had successful outcomes at follow-up. We compared different forms of pituitary hormone dysfunction (growth hormone deficiency, hypogonadism, hypothyroidism, and hypocortisolism) based on the maximal adenoma diameter.
Serum prolactin levels were significantly correlated with the maximal adenoma diameter (r=0.867; P=0.000). Of the patients, 89.2% presented with pituitary failure, which included 74.5% with growth hormone deficiency, 71.6% with hypogonadism, 28.4% with hypothyroidism, and 12.7% with hypocortisolism. The three groups did not differ significantly (P>0.05) in the incidence of hypopituitarism, including the extent of pituitary axis deficiency, at presentation and following treatment. However, there was a statistically significant difference in the degree of hypogonadism in cases of acquired pituitary insufficiency at diagnosis (P=0.000).
In adult males with prolactin-secreting adenomas, the most common form of pituitary hormone dysfunction was growth hormone deficiency and hypogonadism, whereas hypocortisolism was less common. The maximal adenoma diameter and prolactin secretion did not determine hormone insufficiency in adult males with prolactinomas, but these factors did affect the degree of both hypogonadism and hypothyroidism. Smaller tumors were found to recur more frequently than large tumors, and recovery was more common in cases of growth hormone deficiency and hypogonadism.</description><subject>Adult</subject><subject>Adult male</subject><subject>Cohort Studies</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hypopituitarism</subject><subject>Hypopituitarism - blood</subject><subject>Hypopituitarism - diagnostic imaging</subject><subject>Hypothyroidism</subject><subject>Insulin-like growth factors</subject><subject>Laboratories</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neurology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pituitary</subject><subject>Pituitary gland</subject><subject>Pituitary Neoplasms - blood</subject><subject>Pituitary Neoplasms - diagnostic imaging</subject><subject>Prolactin - blood</subject><subject>Prolactinoma</subject><subject>Prolactinoma - blood</subject><subject>Prolactinoma - diagnostic imaging</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Tumors</subject><subject>Variables</subject><subject>Variance analysis</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1q3TAQhUVpaG7SvkIwZNON3ZFkS_Ii0BLyB4Fu0rWQpXGri225ktyQt4_NTbrIpl0NA9_MmTOHkDMKFQUqvuwrO_gJlxgqtvYV0ApY-47sqJKsFK1Q78kOOPBS1UIek5OU9gDAuVAfyDGTwJWSfEcubp_mMPu8-GyiT2Mxm5wxTqkwY5h-FsYtQy5GM2AqHn3-VcwxDMZmP4XRpI_kqDdDwk8v9ZT8uL56uLwt77_f3F1-uy9tzdpc0hZ6AarbLu8YtFJaYVroGO0dd6ppkHUoVW8Y1k6iRMNM7xTUzljbNZSfks-Hvav67wVT1qNPFofBTBiWpKlUDavbmqv_QWnDmao39PwNug9LnFYjGwUSRCvrlRIHysaQUsRez9GPJj5pCnpzpPf6NQu9ZaGB6jWLdfDsZf3Sjej-jr0-fwW-HgBcX_fHY9TJepwsOh_RZu2C_5fGMzbonfY</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Peng, Junxiang</creator><creator>Qiu, Mingxing</creator><creator>Qi, Songtao</creator><creator>Li, Danling</creator><creator>Peng, Yuping</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Hypopituitarism patterns among adult males with prolactinomas</title><author>Peng, Junxiang ; Qiu, Mingxing ; Qi, Songtao ; Li, Danling ; Peng, Yuping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-190f608b1016b20977c6a90b21fd3d855e2be78fa2e4d7e7ea2afd804daccb513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Adult male</topic><topic>Cohort Studies</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hypopituitarism</topic><topic>Hypopituitarism - blood</topic><topic>Hypopituitarism - diagnostic imaging</topic><topic>Hypothyroidism</topic><topic>Insulin-like growth factors</topic><topic>Laboratories</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neurology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pituitary</topic><topic>Pituitary gland</topic><topic>Pituitary Neoplasms - blood</topic><topic>Pituitary Neoplasms - diagnostic imaging</topic><topic>Prolactin - blood</topic><topic>Prolactinoma</topic><topic>Prolactinoma - blood</topic><topic>Prolactinoma - diagnostic imaging</topic><topic>Retrospective Studies</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Tumors</topic><topic>Variables</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Junxiang</creatorcontrib><creatorcontrib>Qiu, Mingxing</creatorcontrib><creatorcontrib>Qi, Songtao</creatorcontrib><creatorcontrib>Li, Danling</creatorcontrib><creatorcontrib>Peng, Yuping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurology and neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Junxiang</au><au>Qiu, Mingxing</au><au>Qi, Songtao</au><au>Li, Danling</au><au>Peng, Yuping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypopituitarism patterns among adult males with prolactinomas</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>144</volume><spage>112</spage><epage>118</epage><pages>112-118</pages><issn>0303-8467</issn><eissn>1872-6968</eissn><coden>CNNSBV</coden><abstract>•A large cohort of male patients with prolactinomas were studied.•A larger cohort may have led to more statistically significant results in the study.•Recovery from visual field defects and hypopituitarism was noted in most of the patients.•Our study provides better insight into hypopituitarism patterns in these patients.•The adenoma size is correlated with the prevalence of pituitary hormone dysfunction.
The objective of this study was to characterize hypopituitarism in adult males with prolactinomas.
We retrospectively analyzed the records of 102 consecutive patients, classified under three categories based on adenoma size at diagnosis: 1.0–2.0cm (group A), 2.1–4.0cm (group B), and >4.0cm (group C). Further, 76 patients had successful outcomes at follow-up. We compared different forms of pituitary hormone dysfunction (growth hormone deficiency, hypogonadism, hypothyroidism, and hypocortisolism) based on the maximal adenoma diameter.
Serum prolactin levels were significantly correlated with the maximal adenoma diameter (r=0.867; P=0.000). Of the patients, 89.2% presented with pituitary failure, which included 74.5% with growth hormone deficiency, 71.6% with hypogonadism, 28.4% with hypothyroidism, and 12.7% with hypocortisolism. The three groups did not differ significantly (P>0.05) in the incidence of hypopituitarism, including the extent of pituitary axis deficiency, at presentation and following treatment. However, there was a statistically significant difference in the degree of hypogonadism in cases of acquired pituitary insufficiency at diagnosis (P=0.000).
In adult males with prolactin-secreting adenomas, the most common form of pituitary hormone dysfunction was growth hormone deficiency and hypogonadism, whereas hypocortisolism was less common. The maximal adenoma diameter and prolactin secretion did not determine hormone insufficiency in adult males with prolactinomas, but these factors did affect the degree of both hypogonadism and hypothyroidism. Smaller tumors were found to recur more frequently than large tumors, and recovery was more common in cases of growth hormone deficiency and hypogonadism.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27038873</pmid><doi>10.1016/j.clineuro.2016.01.029</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Adult male Cohort Studies Follow-Up Studies Humans Hypopituitarism Hypopituitarism - blood Hypopituitarism - diagnostic imaging Hypothyroidism Insulin-like growth factors Laboratories Magnetic Resonance Imaging Male Males Medical imaging Middle Aged Mortality Neurology NMR Nuclear magnetic resonance Pituitary Pituitary gland Pituitary Neoplasms - blood Pituitary Neoplasms - diagnostic imaging Prolactin - blood Prolactinoma Prolactinoma - blood Prolactinoma - diagnostic imaging Retrospective Studies Statistical analysis Studies Tumors Variables Variance analysis |
| title | Hypopituitarism patterns among adult males with prolactinomas |
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