Lineage Switch in MLL-Rearranged Infant Leukemia Following CD19-Directed Therapy

Rearrangements of the mixed lineage leukemia (MLL) gene occur frequently in infants with both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Conversions of leukemia cell lineage are rare, but occur most commonly in the setting of MLL‐rearrangement. Blinatumomab is a bidirection...

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Veröffentlicht in:	Pediatric blood & cancer 2016-06, Vol.63 (6), p.1113-1115
Hauptverfasser:	Rayes, Ahmad, McMasters, Richard L., O'Brien, Maureen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bispecific - therapeutic use Antigens, CD19 Antineoplastic Combined Chemotherapy Protocols - therapeutic use blinatumomab CD19 Cell Lineage - drug effects Chemotherapy Gene Rearrangement Hematology Humans Infant Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology lineage Male MLL Myeloid-Lymphoid Leukemia Protein - genetics Oncology Pediatrics Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
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