Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia

Highlights • Imaging mass spectrometry can provide comprehensive and complementary information on neuronal cell. • Imaging mass spectrometry provided novel data on molecular changes in phosphatidylcholine after transient global ischemia. • Increased level of PC (diacyl-16:0/22:6) in hippocampal CA1...

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Veröffentlicht in:	Neuroscience 2016-05, Vol.322, p.66-77
Hauptverfasser:	Miyawaki, S, Imai, H, Hayasaka, T, Masaki, N, Ono, H, Ochi, T, Ito, A, Nakatomi, H, Setou, M, Saito, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Astrocytes - metabolism Astrocytes - pathology CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - pathology Cell Death - physiology Chronic Disease delayed neuronal cell death Disease Models, Animal Disease Progression Gliosis - metabolism Gliosis - pathology hippocampus imaging mass spectrometry Immunohistochemistry Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Male Mass Spectrometry - methods Microglia - metabolism Microglia - pathology Neurology phosphatidylcholine Phosphatidylcholines - metabolism Rats, Sprague-Dawley Time Factors
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Beschreibung
Zusammenfassung:	Highlights • Imaging mass spectrometry can provide comprehensive and complementary information on neuronal cell. • Imaging mass spectrometry provided novel data on molecular changes in phosphatidylcholine after transient global ischemia. • Increased level of PC (diacyl-16:0/22:6) in hippocampal CA1 may represent an early step in delayed neuronal death mechanisms.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.02.013