Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency

Although the RAG2 core domain is the minimal region required for V(D)J recombination, the noncore region also plays important roles in the regulation of recombination, and mutations in this region are often related to severe combined immunodeficiency. A complete understanding of the functions of the...

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Veröffentlicht in:	European journal of immunology 2016-04, Vol.46 (4), p.1011-1019
Hauptverfasser:	Xu, Ke, Liu, Haifeng, Shi, Zhubing, Song, Guangrong, Zhu, Xiaoyan, Jiang, Yuzhang, Zhou, Zhaocai, Liu, Xiaolong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal models Animals B-Lymphocytes - cytology B-Lymphocytes - immunology Base Sequence Cell differentiation Cells, Cultured Conserved Sequence - genetics Danio rerio Disruption DNA-Binding Proteins - genetics Gene Knockout Techniques Impairment Knout out mice Lymphocytes B Mice Mice, Inbred C57BL Mice, Knockout Molecular Sequence Data Mutation Protein Stability RAG2 protein Rodents Sequence Alignment Severe combined immunodeficiency Severe Combined Immunodeficiency - genetics Severe Combined Immunodeficiency - immunology T-Lymphocytes - cytology T-Lymphocytes - immunology V(D)J recombination V(D)J Recombination - genetics Zinc Zinc finger proteins Zinc Fingers - genetics
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