Agonist‐induced activation of histamine H3 receptor signals to extracellular signal‐regulated kinases 1 and 2 through PKC‐, PLD‐, and EGFR‐dependent mechanisms

The histamine H3 receptor (H3R), abundantly expressed in the central and the peripheral nervous system, has been recognized as a promising target for the treatment of various important CNS diseases including narcolepsy, Alzheimer's disease, and attention deficit hyperactivity disorder. The H3R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2016-04, Vol.137 (2), p.200-215
Hauptverfasser:	Lai, Xiangru, Ye, Lingyan, Liao, Yuan, Jin, Lili, Ma, Qiang, Lu, Bing, Sun, Yi, Shi, Ying, Zhou, Naiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Animals, Newborn Attention deficit hyperactivity disorder Butadienes - pharmacology Cells, Cultured Cercopithecus aethiops Cerebral Cortex - cytology EGFR Enzyme Inhibitors - pharmacology Epidermal growth factor ERK1/2 Glucose - deficiency GPCR H3R Histamine - pharmacology Humans Hypoxia Kinases Mice Mice, Inbred ICR Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Molecular Sequence Data Neurons - drug effects Neurons - metabolism neuroprotection Nitriles - pharmacology Pertussis Toxin - pharmacology Phospholipase D - genetics Phospholipase D - metabolism Phosphorylation Physiology PKC Protein Kinase C - genetics Protein Kinase C - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptors, Histamine H3 - genetics Receptors, Histamine H3 - metabolism Signal Transduction - physiology Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!