Dengue severity associated with age and a new lineage of dengue virus-type 2 during an outbreak in Rio De Janeiro, Brazil
Dengue virus‐type 2 (DENV‐2) caused three outbreaks, in the years 1990, 1998, and 2008, in Rio de Janeiro, Brazil. The 2008 outbreak was the most severe in reported cases, hospitalizations, and deaths. To investigate virological and epidemiological factors that may have contributed to the pathogenic...
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| Veröffentlicht in: | Journal of medical virology 2016-07, Vol.88 (7), p.1130-1136 |
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| creator | Nunes, Priscila Conrado Guerra Sampaio, Simone Alves Faria Rodrigues da Costa, Nieli de Mendonça, Marcos Cesar Lima Lima, Monique da Rocha Queiroz Araujo, Saraiva Eliane M dos Santos, Flávia Barreto Simões, Jaqueline Basto Santos de Santis Gonçalves, Bianca Nogueira, Rita Maria Ribeiro de Filippis, Ana Maria Bispo |
| description | Dengue virus‐type 2 (DENV‐2) caused three outbreaks, in the years 1990, 1998, and 2008, in Rio de Janeiro, Brazil. The 2008 outbreak was the most severe in reported cases, hospitalizations, and deaths. To investigate virological and epidemiological factors that may have contributed to the pathogenic profile of 2008 epidemic, 102 patients sera obtained during the epidemic and inter‐epidemic periods of three outbreaks were analysed by qRT‐PCR to estimate viremia levels and their correlation with the clinical, immunological, and demographic patient characteristics. DENV‐2 isolates from the outbreaks were sequenced. Two DENV‐2 lineages (I and II) of the American/Asian genotype were confirmed, each exclusive for 1990–2002 and 2007–2011, respectively. The mean viremia level in the 2008 samples was two orders of magnitude higher than that of the 1990–2002 samples. Severe dengue cases increased from 31% in 1990–2002 to 69% in 2007–2011; in patients aged ≤15 years, from 3% in 1990–2002 to 37% in 2007–2011. The DENV‐2 lineage II and younger age significantly contributed to the pathogenic profile of 2008 epidemic in Rio de Janeiro. J. Med. Virol. 88:1130–1136, 2016. © 2016 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.24464 |
| format | Article |
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The 2008 outbreak was the most severe in reported cases, hospitalizations, and deaths. To investigate virological and epidemiological factors that may have contributed to the pathogenic profile of 2008 epidemic, 102 patients sera obtained during the epidemic and inter‐epidemic periods of three outbreaks were analysed by qRT‐PCR to estimate viremia levels and their correlation with the clinical, immunological, and demographic patient characteristics. DENV‐2 isolates from the outbreaks were sequenced. Two DENV‐2 lineages (I and II) of the American/Asian genotype were confirmed, each exclusive for 1990–2002 and 2007–2011, respectively. The mean viremia level in the 2008 samples was two orders of magnitude higher than that of the 1990–2002 samples. Severe dengue cases increased from 31% in 1990–2002 to 69% in 2007–2011; in patients aged ≤15 years, from 3% in 1990–2002 to 37% in 2007–2011. The DENV‐2 lineage II and younger age significantly contributed to the pathogenic profile of 2008 epidemic in Rio de Janeiro. J. Med. Virol. 88:1130–1136, 2016. © 2016 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.24464</identifier><identifier>PMID: 27061403</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Brazil - epidemiology ; Dengue fever ; dengue outbreaks ; Dengue Virus - classification ; Dengue Virus - genetics ; Dengue Virus - pathogenicity ; Disease Outbreaks ; Epidemics - statistics & numerical data ; Epidemiology ; Female ; Genotype ; Genotype & phenotype ; Humans ; Male ; Middle Aged ; Phylogeny ; qRT-PCR ; RNA, Viral - blood ; Severe Dengue - epidemiology ; Severe Dengue - virology ; Severity of Illness Index ; viremia ; Viremia - epidemiology ; Viremia - virology ; Virology ; Young Adult</subject><ispartof>Journal of medical virology, 2016-07, Vol.88 (7), p.1130-1136</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4244-e23c01c7bb7b34a449718a6b5bf18b370f0d6837abb8f6068fdd7ab4f753580a3</citedby><cites>FETCH-LOGICAL-c4244-e23c01c7bb7b34a449718a6b5bf18b370f0d6837abb8f6068fdd7ab4f753580a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.24464$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.24464$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27061403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nunes, Priscila Conrado Guerra</creatorcontrib><creatorcontrib>Sampaio, Simone Alves Faria</creatorcontrib><creatorcontrib>Rodrigues da Costa, Nieli</creatorcontrib><creatorcontrib>de Mendonça, Marcos Cesar Lima</creatorcontrib><creatorcontrib>Lima, Monique da Rocha Queiroz</creatorcontrib><creatorcontrib>Araujo, Saraiva Eliane M</creatorcontrib><creatorcontrib>dos Santos, Flávia Barreto</creatorcontrib><creatorcontrib>Simões, Jaqueline Basto Santos</creatorcontrib><creatorcontrib>de Santis Gonçalves, Bianca</creatorcontrib><creatorcontrib>Nogueira, Rita Maria Ribeiro</creatorcontrib><creatorcontrib>de Filippis, Ana Maria Bispo</creatorcontrib><title>Dengue severity associated with age and a new lineage of dengue virus-type 2 during an outbreak in Rio De Janeiro, Brazil</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Dengue virus‐type 2 (DENV‐2) caused three outbreaks, in the years 1990, 1998, and 2008, in Rio de Janeiro, Brazil. The 2008 outbreak was the most severe in reported cases, hospitalizations, and deaths. To investigate virological and epidemiological factors that may have contributed to the pathogenic profile of 2008 epidemic, 102 patients sera obtained during the epidemic and inter‐epidemic periods of three outbreaks were analysed by qRT‐PCR to estimate viremia levels and their correlation with the clinical, immunological, and demographic patient characteristics. DENV‐2 isolates from the outbreaks were sequenced. Two DENV‐2 lineages (I and II) of the American/Asian genotype were confirmed, each exclusive for 1990–2002 and 2007–2011, respectively. The mean viremia level in the 2008 samples was two orders of magnitude higher than that of the 1990–2002 samples. Severe dengue cases increased from 31% in 1990–2002 to 69% in 2007–2011; in patients aged ≤15 years, from 3% in 1990–2002 to 37% in 2007–2011. The DENV‐2 lineage II and younger age significantly contributed to the pathogenic profile of 2008 epidemic in Rio de Janeiro. J. Med. Virol. 88:1130–1136, 2016. © 2016 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Brazil - epidemiology</subject><subject>Dengue fever</subject><subject>dengue outbreaks</subject><subject>Dengue Virus - classification</subject><subject>Dengue Virus - genetics</subject><subject>Dengue Virus - pathogenicity</subject><subject>Disease Outbreaks</subject><subject>Epidemics - statistics & numerical data</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phylogeny</subject><subject>qRT-PCR</subject><subject>RNA, Viral - blood</subject><subject>Severe Dengue - epidemiology</subject><subject>Severe Dengue - virology</subject><subject>Severity of Illness Index</subject><subject>viremia</subject><subject>Viremia - epidemiology</subject><subject>Viremia - virology</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0c1u1DAUBWALgei0sOAFkCU2VCLtdeLYyRJaOmVUfgVladnJzeBpJh7sZIbw9LhN2wUSEqvI0XePfH0IecbgiAGkx6v19ijlXPAHZMagFEkJkj0kM2BcJEKwfI_sh7ACgKJM08dkL5UgGIdsRsZT7JYD0oBb9LYfqQ7BVVb3WNOd7X9QvUSqu5pq2uGOtrbD6z-uofU0uLV-CEk_bpCmtB687ZbRUzf0xqO-orajX6yjp0gXukPr3Sv6xuvftn1CHjW6Dfj09ntAvp29_Xpynlx8nL87eX2RVDzulGCaVcAqaYw0Gdecl5IVWpjcNKwwmYQGalFkUhtTNAJE0dR1PPBG5llegM4OyMspd-PdzwFDr9Y2VNi28TpuCIrJIk95nhfifyjk8cWFjPTFX3TlBt_FRW5UNCAhqsNJVd6F4LFRG2_X2o-KgbquTsXq1E110T6_TRzMGut7eddVBMcT2NkWx38nqcX7y7vIZJqwocdf9xPaX6m4gszV9w9zdXb5qcw-zxfqPPsDOt6wTw</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Nunes, Priscila Conrado Guerra</creator><creator>Sampaio, Simone Alves Faria</creator><creator>Rodrigues da Costa, Nieli</creator><creator>de Mendonça, Marcos Cesar Lima</creator><creator>Lima, Monique da Rocha Queiroz</creator><creator>Araujo, Saraiva Eliane M</creator><creator>dos Santos, Flávia Barreto</creator><creator>Simões, Jaqueline Basto Santos</creator><creator>de Santis Gonçalves, Bianca</creator><creator>Nogueira, Rita Maria Ribeiro</creator><creator>de Filippis, Ana Maria Bispo</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Dengue severity associated with age and a new lineage of dengue virus-type 2 during an outbreak in Rio De Janeiro, Brazil</title><author>Nunes, Priscila Conrado Guerra ; 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Med. Virol</addtitle><date>2016-07</date><risdate>2016</risdate><volume>88</volume><issue>7</issue><spage>1130</spage><epage>1136</epage><pages>1130-1136</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Dengue virus‐type 2 (DENV‐2) caused three outbreaks, in the years 1990, 1998, and 2008, in Rio de Janeiro, Brazil. The 2008 outbreak was the most severe in reported cases, hospitalizations, and deaths. To investigate virological and epidemiological factors that may have contributed to the pathogenic profile of 2008 epidemic, 102 patients sera obtained during the epidemic and inter‐epidemic periods of three outbreaks were analysed by qRT‐PCR to estimate viremia levels and their correlation with the clinical, immunological, and demographic patient characteristics. DENV‐2 isolates from the outbreaks were sequenced. Two DENV‐2 lineages (I and II) of the American/Asian genotype were confirmed, each exclusive for 1990–2002 and 2007–2011, respectively. The mean viremia level in the 2008 samples was two orders of magnitude higher than that of the 1990–2002 samples. Severe dengue cases increased from 31% in 1990–2002 to 69% in 2007–2011; in patients aged ≤15 years, from 3% in 1990–2002 to 37% in 2007–2011. The DENV‐2 lineage II and younger age significantly contributed to the pathogenic profile of 2008 epidemic in Rio de Janeiro. J. Med. Virol. 88:1130–1136, 2016. © 2016 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>27061403</pmid><doi>10.1002/jmv.24464</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Brazil - epidemiology Dengue fever dengue outbreaks Dengue Virus - classification Dengue Virus - genetics Dengue Virus - pathogenicity Disease Outbreaks Epidemics - statistics & numerical data Epidemiology Female Genotype Genotype & phenotype Humans Male Middle Aged Phylogeny qRT-PCR RNA, Viral - blood Severe Dengue - epidemiology Severe Dengue - virology Severity of Illness Index viremia Viremia - epidemiology Viremia - virology Virology Young Adult |
| title | Dengue severity associated with age and a new lineage of dengue virus-type 2 during an outbreak in Rio De Janeiro, Brazil |
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