Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice

•ELF-MF exposure ameliorate cognitive deficits in AD mice.•Tau hyperphosphorylation was also attenuated in AD mice.•ELF-MF treatment maybe a new means to cure AD Although numerous studies have reported the influence of extremely low frequency magnetic field (ELF-MF) exposure on human health, its eff...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2016-03, Vol.53, p.290-300
Hauptverfasser:	Hu, Yu, Lai, Jinsheng, Wan, Baoquan, Liu, Xingfa, Zhang, Yemao, Zhang, Jiangong, Sun, Dongsheng, Ruan, Guoran, Liu, Enjie, Liu, Gong-Ping, Chen, Chen, Wang, Dao Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer Disease - radiotherapy Alzheimer’s disease Amyloid beta-Protein Precursor - genetics Animals Apoptosis - genetics Apoptosis - radiation effects Cognition Disorders - etiology Cognition Disorders - therapy Cognitive Conditioning (Psychology) - physiology Conditioning (Psychology) - radiation effects Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism Disease Models, Animal Dose-Response Relationship, Radiation ELF-MF Gene Expression Regulation - genetics Gene Expression Regulation - radiation effects Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Humans Magnetic Field Therapy - methods Maze Learning - physiology Maze Learning - radiation effects Mice Mice, Inbred C57BL Mice, Transgenic Mutation - genetics Phosphorylation - radiation effects Presenilin-1 - genetics Reactive Oxygen Species - metabolism Tau phosphorylation tau Proteins - genetics tau Proteins - metabolism
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