Focussing reduced representation CpG sequencing through judicious restriction enzyme choice

Current restriction enzyme based reduced representation methylation analyses aim for limited, but unbiased, methylome coverage. As the current best estimate suggests that only ~20% of CpGs are dynamically regulated, we characterised the CpG and genomic context surrounding all suitable restriction en...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2016-04, Vol.107 (4), p.109-119
Hauptverfasser:	Kirschner, Sophie A., Hunewald, Oliver, Mériaux, Sophie B., Brunnhoefer, Regina, Muller, Claude P., Turner, Jonathan D.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 5' Untranslated Regions Animals CpG CpG Islands DNA Methylation DNA Restriction Enzymes - chemistry Gene Library Genomics - methods Mice Next-generation sequencing Promoter Regions, Genetic Restriction enzyme Sequence Analysis, DNA - methods
Online-Zugang:	Volltext
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