n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial
Background Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. n‐3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance. The present study aimed to evaluate the effect...
Gespeichert in:
| Veröffentlicht in: | Journal of human nutrition and dietetics 2016-06, Vol.29 (3), p.345-353 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 353 |
|---|---|
| container_issue | 3 |
| container_start_page | 345 |
| container_title | Journal of human nutrition and dietetics |
| container_volume | 29 |
| creator | Freire, T. O. Boulhosa, R. S. S. B. Oliveira, L. P. M. de Jesus, R. P. Cavalcante, L. N. Lemaire, D. C. Toralles, M. B. P. Lyra, L. G. C. Lyra, A. C. |
| description | Background
Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. n‐3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance.
The present study aimed to evaluate the effect of n‐3 PUFA supplementation on insulin resistance in these patients.
Methods
In a randomised, double‐blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 patients [homeostasis model assessment index of insulin resistance (HOMA‐IR ≥2.5)] were randomly divided into two groups: n‐3 PUFA (n = 25/6000 mg day−1 of fish oil) or control (n = 27/6000 mg day−1 of soybean oil). Both groups were supplemented for 12 weeks and underwent monthly nutritional consultation. Biochemical tests were performed at baseline and after intervention. Statistical analysis was performed using the Wilcoxon Mann–Whitney test for comparisons and the Wilcoxon test for paired data. Statistical package r, version 3.02 (The R Project for Statistical Computing) was used and P |
| doi_str_mv | 10.1111/jhn.12327 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1785241450</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4017955611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4597-8f60e37418ea5b169c829037c5066a51ef6493a9bdd2b59fc3ee519d0a7031a83</originalsourceid><addsrcrecordid>eNqNkctu1DAUhi0EokNhwQsgS2zoIq0vsZ2wQyPaoRrKhtvO8jgnqgePE2wHmKfglXE6bRdISHhjn-PvfLL1I_ScklNa1tn2OpxSxpl6gBaUS1Expb4-RAvSClbxRtEj9CSlLSFEUkIeoyMmGZWybhbod6g4Hge_n0IyeYomQ4d7k_MeG-s6nKZx9LCDkE12Q8ARuslCwi6kybu5Ti5lEyyUFr6GsWDZJbzEP1ycZq4HOzvni2JJr7HB0YRu2LlU2nYIOQ7el2OOzvin6FFvfIJnt_sx-nT-9uNyVa0_XLxbvllXthatqppeEuCqpg0YsaGytQ1rCVdWECmNoNDLuuWm3XQd24i2txxA0LYjRhFOTcOP0auDd4zD9wlS1uU9Frw3AYYpaaoawWpaC_I_KBGUMC4K-vIvdDtMMZSP3FCECNawQp0cKBuHlCL0eoxuZ-JeU6LnQHUJVN8EWtgXt8Zps4PunrxLsABnB-Cn87D_t0lfrq7ulNVhogQHv-4nTPympeJK6C9XF_ryfbtsV-vPuuZ_ADYFusc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780005282</pqid></control><display><type>article</type><title>n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Freire, T. O. ; Boulhosa, R. S. S. B. ; Oliveira, L. P. M. ; de Jesus, R. P. ; Cavalcante, L. N. ; Lemaire, D. C. ; Toralles, M. B. P. ; Lyra, L. G. C. ; Lyra, A. C.</creator><creatorcontrib>Freire, T. O. ; Boulhosa, R. S. S. B. ; Oliveira, L. P. M. ; de Jesus, R. P. ; Cavalcante, L. N. ; Lemaire, D. C. ; Toralles, M. B. P. ; Lyra, L. G. C. ; Lyra, A. C.</creatorcontrib><description>Background
Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. n‐3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance.
The present study aimed to evaluate the effect of n‐3 PUFA supplementation on insulin resistance in these patients.
Methods
In a randomised, double‐blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 patients [homeostasis model assessment index of insulin resistance (HOMA‐IR ≥2.5)] were randomly divided into two groups: n‐3 PUFA (n = 25/6000 mg day−1 of fish oil) or control (n = 27/6000 mg day−1 of soybean oil). Both groups were supplemented for 12 weeks and underwent monthly nutritional consultation. Biochemical tests were performed at baseline and after intervention. Statistical analysis was performed using the Wilcoxon Mann–Whitney test for comparisons and the Wilcoxon test for paired data. Statistical package r, version 3.02 (The R Project for Statistical Computing) was used and P < 0.05 (two‐tailed) was considered statistically significant.
Results
Comparisons between groups showed that n‐3 PUFA supplementation was more effective than the control for reducing HOMA‐IR (P = 0.015) and serum insulin (P = 0.016). The n‐3 PUFA group not only showed a significant reduction in HOMA‐IR 3.8 (3.2–5.0) versus 2.4 (1.8–3.3) (P = 0.002); serum insulin 17.1 (13.8–20.6) μIU mL−1 versus 10.9 (8.6–14.6) μIU mL−1 (P = 0.001); and glycated haemoglobin 5.4% (5.0–5.7%) versus 5.1% (4.8–5.6%) (P = 0.011), but also presented an increase in interleukin‐1 97.5 (0.0–199.8) pg mL−1 versus 192.4 (102.2–266.8) pg mL−1 (P = 0.003) and tumour necrosis factor 121.2 (0.0–171.3) pg mL−1 versus 185.7 (98.0–246.9) pg mL−1 (P = 0.003).
Conclusions
n‐3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients.</description><identifier>ISSN: 0952-3871</identifier><identifier>EISSN: 1365-277X</identifier><identifier>DOI: 10.1111/jhn.12327</identifier><identifier>PMID: 26216648</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Body Mass Index ; chronic hepatitis C ; Dietary Supplements ; Fatty acids ; Fatty Acids, Omega-3 - administration & dosage ; Fatty Liver - complications ; Female ; Fish Oils - administration & dosage ; Genotype ; Hepatitis ; Hepatitis C virus ; Hepatitis C, Chronic - blood ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - drug therapy ; Humans ; inflammation ; Insulin ; Insulin - blood ; Insulin Resistance ; Male ; Middle Aged ; n-3 PUFA supplementation ; nutrition</subject><ispartof>Journal of human nutrition and dietetics, 2016-06, Vol.29 (3), p.345-353</ispartof><rights>2015 The British Dietetic Association Ltd.</rights><rights>Journal of Human Nutrition and Dietetics © 2016 The British Dietetic Association Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4597-8f60e37418ea5b169c829037c5066a51ef6493a9bdd2b59fc3ee519d0a7031a83</citedby><cites>FETCH-LOGICAL-c4597-8f60e37418ea5b169c829037c5066a51ef6493a9bdd2b59fc3ee519d0a7031a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjhn.12327$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjhn.12327$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26216648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freire, T. O.</creatorcontrib><creatorcontrib>Boulhosa, R. S. S. B.</creatorcontrib><creatorcontrib>Oliveira, L. P. M.</creatorcontrib><creatorcontrib>de Jesus, R. P.</creatorcontrib><creatorcontrib>Cavalcante, L. N.</creatorcontrib><creatorcontrib>Lemaire, D. C.</creatorcontrib><creatorcontrib>Toralles, M. B. P.</creatorcontrib><creatorcontrib>Lyra, L. G. C.</creatorcontrib><creatorcontrib>Lyra, A. C.</creatorcontrib><title>n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial</title><title>Journal of human nutrition and dietetics</title><addtitle>J Hum Nutr Diet</addtitle><description>Background
Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. n‐3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance.
The present study aimed to evaluate the effect of n‐3 PUFA supplementation on insulin resistance in these patients.
Methods
In a randomised, double‐blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 patients [homeostasis model assessment index of insulin resistance (HOMA‐IR ≥2.5)] were randomly divided into two groups: n‐3 PUFA (n = 25/6000 mg day−1 of fish oil) or control (n = 27/6000 mg day−1 of soybean oil). Both groups were supplemented for 12 weeks and underwent monthly nutritional consultation. Biochemical tests were performed at baseline and after intervention. Statistical analysis was performed using the Wilcoxon Mann–Whitney test for comparisons and the Wilcoxon test for paired data. Statistical package r, version 3.02 (The R Project for Statistical Computing) was used and P < 0.05 (two‐tailed) was considered statistically significant.
Results
Comparisons between groups showed that n‐3 PUFA supplementation was more effective than the control for reducing HOMA‐IR (P = 0.015) and serum insulin (P = 0.016). The n‐3 PUFA group not only showed a significant reduction in HOMA‐IR 3.8 (3.2–5.0) versus 2.4 (1.8–3.3) (P = 0.002); serum insulin 17.1 (13.8–20.6) μIU mL−1 versus 10.9 (8.6–14.6) μIU mL−1 (P = 0.001); and glycated haemoglobin 5.4% (5.0–5.7%) versus 5.1% (4.8–5.6%) (P = 0.011), but also presented an increase in interleukin‐1 97.5 (0.0–199.8) pg mL−1 versus 192.4 (102.2–266.8) pg mL−1 (P = 0.003) and tumour necrosis factor 121.2 (0.0–171.3) pg mL−1 versus 185.7 (98.0–246.9) pg mL−1 (P = 0.003).
Conclusions
n‐3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Body Mass Index</subject><subject>chronic hepatitis C</subject><subject>Dietary Supplements</subject><subject>Fatty acids</subject><subject>Fatty Acids, Omega-3 - administration & dosage</subject><subject>Fatty Liver - complications</subject><subject>Female</subject><subject>Fish Oils - administration & dosage</subject><subject>Genotype</subject><subject>Hepatitis</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic - blood</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Humans</subject><subject>inflammation</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Middle Aged</subject><subject>n-3 PUFA supplementation</subject><subject>nutrition</subject><issn>0952-3871</issn><issn>1365-277X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1DAUhi0EokNhwQsgS2zoIq0vsZ2wQyPaoRrKhtvO8jgnqgePE2wHmKfglXE6bRdISHhjn-PvfLL1I_ScklNa1tn2OpxSxpl6gBaUS1Expb4-RAvSClbxRtEj9CSlLSFEUkIeoyMmGZWybhbod6g4Hge_n0IyeYomQ4d7k_MeG-s6nKZx9LCDkE12Q8ARuslCwi6kybu5Ti5lEyyUFr6GsWDZJbzEP1ycZq4HOzvni2JJr7HB0YRu2LlU2nYIOQ7el2OOzvin6FFvfIJnt_sx-nT-9uNyVa0_XLxbvllXthatqppeEuCqpg0YsaGytQ1rCVdWECmNoNDLuuWm3XQd24i2txxA0LYjRhFOTcOP0auDd4zD9wlS1uU9Frw3AYYpaaoawWpaC_I_KBGUMC4K-vIvdDtMMZSP3FCECNawQp0cKBuHlCL0eoxuZ-JeU6LnQHUJVN8EWtgXt8Zps4PunrxLsABnB-Cn87D_t0lfrq7ulNVhogQHv-4nTPympeJK6C9XF_ryfbtsV-vPuuZ_ADYFusc</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Freire, T. O.</creator><creator>Boulhosa, R. S. S. B.</creator><creator>Oliveira, L. P. M.</creator><creator>de Jesus, R. P.</creator><creator>Cavalcante, L. N.</creator><creator>Lemaire, D. C.</creator><creator>Toralles, M. B. P.</creator><creator>Lyra, L. G. C.</creator><creator>Lyra, A. C.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>201606</creationdate><title>n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial</title><author>Freire, T. O. ; Boulhosa, R. S. S. B. ; Oliveira, L. P. M. ; de Jesus, R. P. ; Cavalcante, L. N. ; Lemaire, D. C. ; Toralles, M. B. P. ; Lyra, L. G. C. ; Lyra, A. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4597-8f60e37418ea5b169c829037c5066a51ef6493a9bdd2b59fc3ee519d0a7031a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Body Mass Index</topic><topic>chronic hepatitis C</topic><topic>Dietary Supplements</topic><topic>Fatty acids</topic><topic>Fatty Acids, Omega-3 - administration & dosage</topic><topic>Fatty Liver - complications</topic><topic>Female</topic><topic>Fish Oils - administration & dosage</topic><topic>Genotype</topic><topic>Hepatitis</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic - blood</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Humans</topic><topic>inflammation</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Middle Aged</topic><topic>n-3 PUFA supplementation</topic><topic>nutrition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freire, T. O.</creatorcontrib><creatorcontrib>Boulhosa, R. S. S. B.</creatorcontrib><creatorcontrib>Oliveira, L. P. M.</creatorcontrib><creatorcontrib>de Jesus, R. P.</creatorcontrib><creatorcontrib>Cavalcante, L. N.</creatorcontrib><creatorcontrib>Lemaire, D. C.</creatorcontrib><creatorcontrib>Toralles, M. B. P.</creatorcontrib><creatorcontrib>Lyra, L. G. C.</creatorcontrib><creatorcontrib>Lyra, A. C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of human nutrition and dietetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freire, T. O.</au><au>Boulhosa, R. S. S. B.</au><au>Oliveira, L. P. M.</au><au>de Jesus, R. P.</au><au>Cavalcante, L. N.</au><au>Lemaire, D. C.</au><au>Toralles, M. B. P.</au><au>Lyra, L. G. C.</au><au>Lyra, A. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial</atitle><jtitle>Journal of human nutrition and dietetics</jtitle><addtitle>J Hum Nutr Diet</addtitle><date>2016-06</date><risdate>2016</risdate><volume>29</volume><issue>3</issue><spage>345</spage><epage>353</epage><pages>345-353</pages><issn>0952-3871</issn><eissn>1365-277X</eissn><abstract>Background
Insulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. n‐3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance.
The present study aimed to evaluate the effect of n‐3 PUFA supplementation on insulin resistance in these patients.
Methods
In a randomised, double‐blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 patients [homeostasis model assessment index of insulin resistance (HOMA‐IR ≥2.5)] were randomly divided into two groups: n‐3 PUFA (n = 25/6000 mg day−1 of fish oil) or control (n = 27/6000 mg day−1 of soybean oil). Both groups were supplemented for 12 weeks and underwent monthly nutritional consultation. Biochemical tests were performed at baseline and after intervention. Statistical analysis was performed using the Wilcoxon Mann–Whitney test for comparisons and the Wilcoxon test for paired data. Statistical package r, version 3.02 (The R Project for Statistical Computing) was used and P < 0.05 (two‐tailed) was considered statistically significant.
Results
Comparisons between groups showed that n‐3 PUFA supplementation was more effective than the control for reducing HOMA‐IR (P = 0.015) and serum insulin (P = 0.016). The n‐3 PUFA group not only showed a significant reduction in HOMA‐IR 3.8 (3.2–5.0) versus 2.4 (1.8–3.3) (P = 0.002); serum insulin 17.1 (13.8–20.6) μIU mL−1 versus 10.9 (8.6–14.6) μIU mL−1 (P = 0.001); and glycated haemoglobin 5.4% (5.0–5.7%) versus 5.1% (4.8–5.6%) (P = 0.011), but also presented an increase in interleukin‐1 97.5 (0.0–199.8) pg mL−1 versus 192.4 (102.2–266.8) pg mL−1 (P = 0.003) and tumour necrosis factor 121.2 (0.0–171.3) pg mL−1 versus 185.7 (98.0–246.9) pg mL−1 (P = 0.003).
Conclusions
n‐3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26216648</pmid><doi>10.1111/jhn.12327</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-3871 |
| ispartof | Journal of human nutrition and dietetics, 2016-06, Vol.29 (3), p.345-353 |
| issn | 0952-3871 1365-277X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1785241450 |
| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Adult Aged Body Mass Index chronic hepatitis C Dietary Supplements Fatty acids Fatty Acids, Omega-3 - administration & dosage Fatty Liver - complications Female Fish Oils - administration & dosage Genotype Hepatitis Hepatitis C virus Hepatitis C, Chronic - blood Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Humans inflammation Insulin Insulin - blood Insulin Resistance Male Middle Aged n-3 PUFA supplementation nutrition |
| title | n-3 polyunsaturated fatty acid supplementation reduces insulin resistance in hepatitis C virus infected patients: a randomised controlled trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T01%3A44%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=n-3%20polyunsaturated%20fatty%20acid%20supplementation%20reduces%20insulin%20resistance%20in%20hepatitis%20C%20virus%20infected%20patients:%20a%20randomised%20controlled%20trial&rft.jtitle=Journal%20of%20human%20nutrition%20and%20dietetics&rft.au=Freire,%20T.%20O.&rft.date=2016-06&rft.volume=29&rft.issue=3&rft.spage=345&rft.epage=353&rft.pages=345-353&rft.issn=0952-3871&rft.eissn=1365-277X&rft_id=info:doi/10.1111/jhn.12327&rft_dat=%3Cproquest_cross%3E4017955611%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780005282&rft_id=info:pmid/26216648&rfr_iscdi=true |