Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) in China: an integrated data analysis
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS pat...
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Veröffentlicht in: | Epidemiology and infection 2016-04, Vol.144 (6), p.1345-1354 |
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creator | GUO, C.-T. LU, Q.-B. DING, S.-J. HU, C.-Y. HU, J.-G. WO, Y. FAN, Y.-D. WANG, X.-J. QIN, S.-L. CUI, N. YANG, Z.-D. ZHANG, X.-A. LIU, W. CAO, W.-C. |
description | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS patients was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of acute infection, hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of SFTSV infection were fever, anorexia, myalgia, chill and lymphadenopathy. The major laboratory findings were elevated lactate dehydrogenase, aminotransferase, followed by thrombocytopenia, lymphocytopenia, elevated alanine transaminase and creatine kinase. A CFR of 12·2% was estimated, significantly higher than that obtained from national reporting data, but showing no geographical difference. In our paper, the mortality rate was about 1·9 parts per million. Older age and longer delay to hospitalization were significantly associated with fatal outcome. A pooled seroprevalence of 3·0% was obtained, which increased with age, while comparable for gender. This study represents a clinical characterization on the largest group of SFTS patients up to now. A higher than expected CFR was obtained. A wider spectrum of clinical index was suggested to be used to identify SFTSV infection, while the useful predictor for fatal outcome was found to be restricted. |
doi_str_mv | 10.1017/S0950268815002678 |
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The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS patients was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of acute infection, hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of SFTSV infection were fever, anorexia, myalgia, chill and lymphadenopathy. The major laboratory findings were elevated lactate dehydrogenase, aminotransferase, followed by thrombocytopenia, lymphocytopenia, elevated alanine transaminase and creatine kinase. A CFR of 12·2% was estimated, significantly higher than that obtained from national reporting data, but showing no geographical difference. In our paper, the mortality rate was about 1·9 parts per million. Older age and longer delay to hospitalization were significantly associated with fatal outcome. A pooled seroprevalence of 3·0% was obtained, which increased with age, while comparable for gender. This study represents a clinical characterization on the largest group of SFTS patients up to now. A higher than expected CFR was obtained. A wider spectrum of clinical index was suggested to be used to identify SFTSV infection, while the useful predictor for fatal outcome was found to be restricted.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268815002678</identifier><identifier>PMID: 26542444</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Asymptomatic Infections - epidemiology ; Asymptomatic Infections - mortality ; Bunyaviridae Infections - epidemiology ; Bunyaviridae Infections - mortality ; Bunyaviridae Infections - virology ; Bunyavirus ; China - epidemiology ; Communicable Diseases, Emerging - epidemiology ; Communicable Diseases, Emerging - mortality ; Communicable Diseases, Emerging - virology ; Datasets ; Fatalities ; Female ; Fever - epidemiology ; Fever - virology ; Gender ; Health care ; Hospitalization ; Hospitals ; Humans ; Incidence ; Infections ; Infectious diseases ; Literature reviews ; Male ; Medical laboratories ; Middle Aged ; Original Papers ; Phlebovirus - physiology ; Population ; Prevalence ; Seroepidemiologic Studies ; Serology ; Socioeconomic Factors ; Thrombocytopenia ; Thrombocytopenia - epidemiology ; Thrombocytopenia - mortality ; Thrombocytopenia - virology</subject><ispartof>Epidemiology and infection, 2016-04, Vol.144 (6), p.1345-1354</ispartof><rights>Copyright © Cambridge University Press 2015</rights><rights>Cambridge University Press 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-2da93ffb62cc6f287d12ca4462da19f56a7794918259f22c65ed75b7ae4039233</citedby><cites>FETCH-LOGICAL-c519t-2da93ffb62cc6f287d12ca4462da19f56a7794918259f22c65ed75b7ae4039233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26515628$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26515628$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26542444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUO, C.-T.</creatorcontrib><creatorcontrib>LU, Q.-B.</creatorcontrib><creatorcontrib>DING, S.-J.</creatorcontrib><creatorcontrib>HU, C.-Y.</creatorcontrib><creatorcontrib>HU, J.-G.</creatorcontrib><creatorcontrib>WO, Y.</creatorcontrib><creatorcontrib>FAN, Y.-D.</creatorcontrib><creatorcontrib>WANG, X.-J.</creatorcontrib><creatorcontrib>QIN, S.-L.</creatorcontrib><creatorcontrib>CUI, N.</creatorcontrib><creatorcontrib>YANG, Z.-D.</creatorcontrib><creatorcontrib>ZHANG, X.-A.</creatorcontrib><creatorcontrib>LIU, W.</creatorcontrib><creatorcontrib>CAO, W.-C.</creatorcontrib><title>Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) in China: an integrated data analysis</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS patients was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of acute infection, hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of SFTSV infection were fever, anorexia, myalgia, chill and lymphadenopathy. The major laboratory findings were elevated lactate dehydrogenase, aminotransferase, followed by thrombocytopenia, lymphocytopenia, elevated alanine transaminase and creatine kinase. A CFR of 12·2% was estimated, significantly higher than that obtained from national reporting data, but showing no geographical difference. In our paper, the mortality rate was about 1·9 parts per million. Older age and longer delay to hospitalization were significantly associated with fatal outcome. A pooled seroprevalence of 3·0% was obtained, which increased with age, while comparable for gender. This study represents a clinical characterization on the largest group of SFTS patients up to now. A higher than expected CFR was obtained. A wider spectrum of clinical index was suggested to be used to identify SFTSV infection, while the useful predictor for fatal outcome was found to be restricted.</description><subject>Adult</subject><subject>Aged</subject><subject>Asymptomatic Infections - epidemiology</subject><subject>Asymptomatic Infections - mortality</subject><subject>Bunyaviridae Infections - epidemiology</subject><subject>Bunyaviridae Infections - mortality</subject><subject>Bunyaviridae Infections - virology</subject><subject>Bunyavirus</subject><subject>China - epidemiology</subject><subject>Communicable Diseases, Emerging - epidemiology</subject><subject>Communicable Diseases, Emerging - mortality</subject><subject>Communicable Diseases, Emerging - virology</subject><subject>Datasets</subject><subject>Fatalities</subject><subject>Female</subject><subject>Fever - epidemiology</subject><subject>Fever - virology</subject><subject>Gender</subject><subject>Health care</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Literature reviews</subject><subject>Male</subject><subject>Medical laboratories</subject><subject>Middle Aged</subject><subject>Original Papers</subject><subject>Phlebovirus - 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Academic</collection><collection>Safety Science and Risk</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUO, C.-T.</au><au>LU, Q.-B.</au><au>DING, S.-J.</au><au>HU, C.-Y.</au><au>HU, J.-G.</au><au>WO, Y.</au><au>FAN, Y.-D.</au><au>WANG, X.-J.</au><au>QIN, S.-L.</au><au>CUI, N.</au><au>YANG, Z.-D.</au><au>ZHANG, X.-A.</au><au>LIU, W.</au><au>CAO, W.-C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) in China: an integrated data analysis</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2016-04</date><risdate>2016</risdate><volume>144</volume><issue>6</issue><spage>1345</spage><epage>1354</epage><pages>1345-1354</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS patients was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of acute infection, hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of SFTSV infection were fever, anorexia, myalgia, chill and lymphadenopathy. The major laboratory findings were elevated lactate dehydrogenase, aminotransferase, followed by thrombocytopenia, lymphocytopenia, elevated alanine transaminase and creatine kinase. A CFR of 12·2% was estimated, significantly higher than that obtained from national reporting data, but showing no geographical difference. In our paper, the mortality rate was about 1·9 parts per million. Older age and longer delay to hospitalization were significantly associated with fatal outcome. A pooled seroprevalence of 3·0% was obtained, which increased with age, while comparable for gender. This study represents a clinical characterization on the largest group of SFTS patients up to now. A higher than expected CFR was obtained. A wider spectrum of clinical index was suggested to be used to identify SFTSV infection, while the useful predictor for fatal outcome was found to be restricted.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>26542444</pmid><doi>10.1017/S0950268815002678</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Asymptomatic Infections - epidemiology Asymptomatic Infections - mortality Bunyaviridae Infections - epidemiology Bunyaviridae Infections - mortality Bunyaviridae Infections - virology Bunyavirus China - epidemiology Communicable Diseases, Emerging - epidemiology Communicable Diseases, Emerging - mortality Communicable Diseases, Emerging - virology Datasets Fatalities Female Fever - epidemiology Fever - virology Gender Health care Hospitalization Hospitals Humans Incidence Infections Infectious diseases Literature reviews Male Medical laboratories Middle Aged Original Papers Phlebovirus - physiology Population Prevalence Seroepidemiologic Studies Serology Socioeconomic Factors Thrombocytopenia Thrombocytopenia - epidemiology Thrombocytopenia - mortality Thrombocytopenia - virology |
title | Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) in China: an integrated data analysis |
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