Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) in China: an integrated data analysis

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS pat...

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Veröffentlicht in:Epidemiology and infection 2016-04, Vol.144 (6), p.1345-1354
Hauptverfasser: GUO, C.-T., LU, Q.-B., DING, S.-J., HU, C.-Y., HU, J.-G., WO, Y., FAN, Y.-D., WANG, X.-J., QIN, S.-L., CUI, N., YANG, Z.-D., ZHANG, X.-A., LIU, W., CAO, W.-C.
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container_end_page 1354
container_issue 6
container_start_page 1345
container_title Epidemiology and infection
container_volume 144
creator GUO, C.-T.
LU, Q.-B.
DING, S.-J.
HU, C.-Y.
HU, J.-G.
WO, Y.
FAN, Y.-D.
WANG, X.-J.
QIN, S.-L.
CUI, N.
YANG, Z.-D.
ZHANG, X.-A.
LIU, W.
CAO, W.-C.
description Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by a novel bunyavirus, SFTSV. The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS patients was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of acute infection, hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of SFTSV infection were fever, anorexia, myalgia, chill and lymphadenopathy. The major laboratory findings were elevated lactate dehydrogenase, aminotransferase, followed by thrombocytopenia, lymphocytopenia, elevated alanine transaminase and creatine kinase. A CFR of 12·2% was estimated, significantly higher than that obtained from national reporting data, but showing no geographical difference. In our paper, the mortality rate was about 1·9 parts per million. Older age and longer delay to hospitalization were significantly associated with fatal outcome. A pooled seroprevalence of 3·0% was obtained, which increased with age, while comparable for gender. This study represents a clinical characterization on the largest group of SFTS patients up to now. A higher than expected CFR was obtained. A wider spectrum of clinical index was suggested to be used to identify SFTSV infection, while the useful predictor for fatal outcome was found to be restricted.
doi_str_mv 10.1017/S0950268815002678
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The study aimed to disclose the epidemiological and clinical characteristics of SFTSV infection in China so far. An integrated clinical database comprising 1920 SFTS patients was constructed by combining first-hand clinical information collected from SFTS sentinel hospitals (n = 1159) and extracted data (n = 761) from published literature. The considered variables comprised clinical manifestations, routine laboratory tests of acute infection, hospitalization duration and disease outcome. SFTSV-IgG data from 19 119 healthy subjects were extracted from the published papers. The key clinical variables, case-fatality rate (CFR) and seroprevalence were estimated by meta-analysis. The most commonly seen clinical manifestations of SFTSV infection were fever, anorexia, myalgia, chill and lymphadenopathy. The major laboratory findings were elevated lactate dehydrogenase, aminotransferase, followed by thrombocytopenia, lymphocytopenia, elevated alanine transaminase and creatine kinase. 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ispartof Epidemiology and infection, 2016-04, Vol.144 (6), p.1345-1354
issn 0950-2688
1469-4409
language eng
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source MEDLINE; Jstor Complete Legacy; PubMed Central
subjects Adult
Aged
Asymptomatic Infections - epidemiology
Asymptomatic Infections - mortality
Bunyaviridae Infections - epidemiology
Bunyaviridae Infections - mortality
Bunyaviridae Infections - virology
Bunyavirus
China - epidemiology
Communicable Diseases, Emerging - epidemiology
Communicable Diseases, Emerging - mortality
Communicable Diseases, Emerging - virology
Datasets
Fatalities
Female
Fever - epidemiology
Fever - virology
Gender
Health care
Hospitalization
Hospitals
Humans
Incidence
Infections
Infectious diseases
Literature reviews
Male
Medical laboratories
Middle Aged
Original Papers
Phlebovirus - physiology
Population
Prevalence
Seroepidemiologic Studies
Serology
Socioeconomic Factors
Thrombocytopenia
Thrombocytopenia - epidemiology
Thrombocytopenia - mortality
Thrombocytopenia - virology
title Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) in China: an integrated data analysis
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