Pros and cons of VP1-specific maternal IgG for the protection of Enterovirus 71 infection
Abstract Enterovirus 71 (EV71) causes hand, foot, and mouth diseases and can result in severe neurological disorders when it infects the central nervous system. Thus, there is a need for the development of effective vaccines against EV71 infection. Here we report that viral capsid protein 1 (VP1), o...
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| Veröffentlicht in: | Vaccine 2015-11, Vol.33 (48), p.6604-6610 |
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| creator | Kim, Young-In Song, Jae-Hyoung Kwon, Bo-Eun Kim, Ha-Neul Seo, Min-Duk Park, KwiSung Lee, SangWon Yeo, Sang-Gu Kweon, Mi-Na Ko, Hyun-Jeong Chang, Sun-Young |
| description | Abstract Enterovirus 71 (EV71) causes hand, foot, and mouth diseases and can result in severe neurological disorders when it infects the central nervous system. Thus, there is a need for the development of effective vaccines against EV71 infection. Here we report that viral capsid protein 1 (VP1), one of the main capsid proteins of EV71, efficiently elicited VP1-specific immunoglobulin G (IgG) in the serum of mice immunized with recombinant VP1. The VP1-specific IgG produced in female mice was efficiently transferred to their offspring, conferring protection against EV71 infection immediately after birth. VP1-specific antibody can neutralize EV71 infection and protect host cells. VP1-specific maternal IgG in offspring was maintained for over 6 months. However, the pre-existence of VP1-specific maternal IgG interfered with the production of VP1-specific IgG antibody secreting cells by active immunization in offspring. Therefore, although our results showed the potential for VP1-specific maternal IgG protection against EV71 in neonatal mice, other strategies must be developed to overcome the hindrance of maternal IgG in active immunization. In this study, we developed an effective and feasible animal model to evaluate the protective efficacy of humoral immunity against EV71 infection using a maternal immunity concept. |
| doi_str_mv | 10.1016/j.vaccine.2015.10.103 |
| format | Article |
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Thus, there is a need for the development of effective vaccines against EV71 infection. Here we report that viral capsid protein 1 (VP1), one of the main capsid proteins of EV71, efficiently elicited VP1-specific immunoglobulin G (IgG) in the serum of mice immunized with recombinant VP1. The VP1-specific IgG produced in female mice was efficiently transferred to their offspring, conferring protection against EV71 infection immediately after birth. VP1-specific antibody can neutralize EV71 infection and protect host cells. VP1-specific maternal IgG in offspring was maintained for over 6 months. However, the pre-existence of VP1-specific maternal IgG interfered with the production of VP1-specific IgG antibody secreting cells by active immunization in offspring. Therefore, although our results showed the potential for VP1-specific maternal IgG protection against EV71 in neonatal mice, other strategies must be developed to overcome the hindrance of maternal IgG in active immunization. In this study, we developed an effective and feasible animal model to evaluate the protective efficacy of humoral immunity against EV71 infection using a maternal immunity concept.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2015.10.103</identifier><identifier>PMID: 26529069</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age ; Allergy and Immunology ; Animal models ; Animals ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Central nervous system ; Conflicts of interest ; Disease Models, Animal ; E coli ; Enterovirus ; Enterovirus 71 ; Enterovirus A, Human - immunology ; Enterovirus Infections - immunology ; Enterovirus Infections - prevention & control ; Female ; Immunity, Humoral ; Immunity, Maternally-Acquired ; Immunization ; Immunoglobulin G - blood ; Immunoglobulin G - immunology ; Infections ; Maternal IgG ; Mice ; Mice, Inbred BALB C ; Offspring ; Pre-existing immunity ; Protective immunity ; Proteins ; Rodents ; Transgenic animals ; Vaccines ; Viral Structural Proteins - chemistry ; Viral Structural Proteins - genetics ; Viral Structural Proteins - immunology ; Viral Vaccines - administration & dosage ; Viral Vaccines - immunology ; VP1</subject><ispartof>Vaccine, 2015-11, Vol.33 (48), p.6604-6610</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 27, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-748695b8e251776c47218b83898c68b7a97ed87df732bfc8084848f6a19c136e3</citedby><cites>FETCH-LOGICAL-c547t-748695b8e251776c47218b83898c68b7a97ed87df732bfc8084848f6a19c136e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X15015595$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26529069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Young-In</creatorcontrib><creatorcontrib>Song, Jae-Hyoung</creatorcontrib><creatorcontrib>Kwon, Bo-Eun</creatorcontrib><creatorcontrib>Kim, Ha-Neul</creatorcontrib><creatorcontrib>Seo, Min-Duk</creatorcontrib><creatorcontrib>Park, KwiSung</creatorcontrib><creatorcontrib>Lee, SangWon</creatorcontrib><creatorcontrib>Yeo, Sang-Gu</creatorcontrib><creatorcontrib>Kweon, Mi-Na</creatorcontrib><creatorcontrib>Ko, Hyun-Jeong</creatorcontrib><creatorcontrib>Chang, Sun-Young</creatorcontrib><title>Pros and cons of VP1-specific maternal IgG for the protection of Enterovirus 71 infection</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Enterovirus 71 (EV71) causes hand, foot, and mouth diseases and can result in severe neurological disorders when it infects the central nervous system. Thus, there is a need for the development of effective vaccines against EV71 infection. Here we report that viral capsid protein 1 (VP1), one of the main capsid proteins of EV71, efficiently elicited VP1-specific immunoglobulin G (IgG) in the serum of mice immunized with recombinant VP1. The VP1-specific IgG produced in female mice was efficiently transferred to their offspring, conferring protection against EV71 infection immediately after birth. VP1-specific antibody can neutralize EV71 infection and protect host cells. VP1-specific maternal IgG in offspring was maintained for over 6 months. However, the pre-existence of VP1-specific maternal IgG interfered with the production of VP1-specific IgG antibody secreting cells by active immunization in offspring. Therefore, although our results showed the potential for VP1-specific maternal IgG protection against EV71 in neonatal mice, other strategies must be developed to overcome the hindrance of maternal IgG in active immunization. In this study, we developed an effective and feasible animal model to evaluate the protective efficacy of humoral immunity against EV71 infection using a maternal immunity concept.</description><subject>Age</subject><subject>Allergy and Immunology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Central nervous system</subject><subject>Conflicts of interest</subject><subject>Disease Models, Animal</subject><subject>E coli</subject><subject>Enterovirus</subject><subject>Enterovirus 71</subject><subject>Enterovirus A, Human - immunology</subject><subject>Enterovirus Infections - immunology</subject><subject>Enterovirus Infections - prevention & control</subject><subject>Female</subject><subject>Immunity, Humoral</subject><subject>Immunity, Maternally-Acquired</subject><subject>Immunization</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Infections</subject><subject>Maternal IgG</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Offspring</subject><subject>Pre-existing immunity</subject><subject>Protective immunity</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Transgenic animals</subject><subject>Vaccines</subject><subject>Viral Structural Proteins - chemistry</subject><subject>Viral Structural Proteins - genetics</subject><subject>Viral Structural Proteins - immunology</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - immunology</subject><subject>VP1</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkkuLFDEUhYMoTtv6E5SAGzfV5lF5bRQZxnFgwAEf6CqkUrc0bXXSU6lqmH8_qalWYTZKFoHkuyc351yEnlOyoYTK19vNwXkfImwYoWJzd8wfoBXVildMUP0QrQiTdVVT8u0EPcl5SwgRnJrH6IRJwQyRZoW-Xw0pYxdb7FPMOHX46xWt8h586ILHOzfCEF2PL36c4y4NePwJeD-kEfwYUpz5s1iQdAjDlLGiOMRuuXuKHnWuz_DsuK_Rl_dnn08_VJcfzy9O311WXtRqrFStpRGNhtKzUtLXilHdaK6N9lI3yhkFrVZtpzhrOq-JrsvqpKPGUy6Br9GrRbe0dT1BHu0uZA997yKkKVuqtGBcC23-A62NJIYXm9bo5T10m6bZiZkSXCmmal4osVC-uJgH6Ox-CDs33FhK7ByT3dpjTHaOaTme614c1admB-2fqt-5FODtAkBx7hBgsNkHiB7aMBR7bZvCP594c0_B9yEG7_pfcAP5729sZpbYT_OszKNCRRERRvBb_wS33A</recordid><startdate>20151127</startdate><enddate>20151127</enddate><creator>Kim, Young-In</creator><creator>Song, Jae-Hyoung</creator><creator>Kwon, Bo-Eun</creator><creator>Kim, Ha-Neul</creator><creator>Seo, Min-Duk</creator><creator>Park, KwiSung</creator><creator>Lee, SangWon</creator><creator>Yeo, Sang-Gu</creator><creator>Kweon, Mi-Na</creator><creator>Ko, Hyun-Jeong</creator><creator>Chang, Sun-Young</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope></search><sort><creationdate>20151127</creationdate><title>Pros and cons of VP1-specific maternal IgG for the protection of Enterovirus 71 infection</title><author>Kim, Young-In ; Song, Jae-Hyoung ; Kwon, Bo-Eun ; Kim, Ha-Neul ; Seo, Min-Duk ; Park, KwiSung ; Lee, SangWon ; Yeo, Sang-Gu ; Kweon, Mi-Na ; Ko, Hyun-Jeong ; Chang, Sun-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-748695b8e251776c47218b83898c68b7a97ed87df732bfc8084848f6a19c136e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Allergy and Immunology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>Central nervous system</topic><topic>Conflicts of interest</topic><topic>Disease Models, Animal</topic><topic>E coli</topic><topic>Enterovirus</topic><topic>Enterovirus 71</topic><topic>Enterovirus A, Human - immunology</topic><topic>Enterovirus Infections - immunology</topic><topic>Enterovirus Infections - prevention & control</topic><topic>Female</topic><topic>Immunity, Humoral</topic><topic>Immunity, Maternally-Acquired</topic><topic>Immunization</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - immunology</topic><topic>Infections</topic><topic>Maternal IgG</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Offspring</topic><topic>Pre-existing immunity</topic><topic>Protective immunity</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Transgenic animals</topic><topic>Vaccines</topic><topic>Viral Structural Proteins - chemistry</topic><topic>Viral Structural Proteins - genetics</topic><topic>Viral Structural Proteins - immunology</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - immunology</topic><topic>VP1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Young-In</creatorcontrib><creatorcontrib>Song, Jae-Hyoung</creatorcontrib><creatorcontrib>Kwon, Bo-Eun</creatorcontrib><creatorcontrib>Kim, Ha-Neul</creatorcontrib><creatorcontrib>Seo, Min-Duk</creatorcontrib><creatorcontrib>Park, KwiSung</creatorcontrib><creatorcontrib>Lee, SangWon</creatorcontrib><creatorcontrib>Yeo, Sang-Gu</creatorcontrib><creatorcontrib>Kweon, Mi-Na</creatorcontrib><creatorcontrib>Ko, Hyun-Jeong</creatorcontrib><creatorcontrib>Chang, Sun-Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Young-In</au><au>Song, Jae-Hyoung</au><au>Kwon, Bo-Eun</au><au>Kim, Ha-Neul</au><au>Seo, Min-Duk</au><au>Park, KwiSung</au><au>Lee, SangWon</au><au>Yeo, Sang-Gu</au><au>Kweon, Mi-Na</au><au>Ko, Hyun-Jeong</au><au>Chang, Sun-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pros and cons of VP1-specific maternal IgG for the protection of Enterovirus 71 infection</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2015-11-27</date><risdate>2015</risdate><volume>33</volume><issue>48</issue><spage>6604</spage><epage>6610</epage><pages>6604-6610</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Abstract Enterovirus 71 (EV71) causes hand, foot, and mouth diseases and can result in severe neurological disorders when it infects the central nervous system. Thus, there is a need for the development of effective vaccines against EV71 infection. Here we report that viral capsid protein 1 (VP1), one of the main capsid proteins of EV71, efficiently elicited VP1-specific immunoglobulin G (IgG) in the serum of mice immunized with recombinant VP1. The VP1-specific IgG produced in female mice was efficiently transferred to their offspring, conferring protection against EV71 infection immediately after birth. VP1-specific antibody can neutralize EV71 infection and protect host cells. VP1-specific maternal IgG in offspring was maintained for over 6 months. However, the pre-existence of VP1-specific maternal IgG interfered with the production of VP1-specific IgG antibody secreting cells by active immunization in offspring. Therefore, although our results showed the potential for VP1-specific maternal IgG protection against EV71 in neonatal mice, other strategies must be developed to overcome the hindrance of maternal IgG in active immunization. In this study, we developed an effective and feasible animal model to evaluate the protective efficacy of humoral immunity against EV71 infection using a maternal immunity concept.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26529069</pmid><doi>10.1016/j.vaccine.2015.10.103</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Allergy and Immunology Animal models Animals Antibodies, Viral - blood Antibodies, Viral - immunology Central nervous system Conflicts of interest Disease Models, Animal E coli Enterovirus Enterovirus 71 Enterovirus A, Human - immunology Enterovirus Infections - immunology Enterovirus Infections - prevention & control Female Immunity, Humoral Immunity, Maternally-Acquired Immunization Immunoglobulin G - blood Immunoglobulin G - immunology Infections Maternal IgG Mice Mice, Inbred BALB C Offspring Pre-existing immunity Protective immunity Proteins Rodents Transgenic animals Vaccines Viral Structural Proteins - chemistry Viral Structural Proteins - genetics Viral Structural Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology VP1 |
| title | Pros and cons of VP1-specific maternal IgG for the protection of Enterovirus 71 infection |
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