Twenty‐Year Longitudinal Follow‐Up After Orthotopic Liver Transplantation: A Single‐Center Experience of 313 Consecutive Cases
With excellent short‐term survival in liver transplantation (LT), we now focus on long‐term outcome and report the first European single‐center 20‐year survival data. Three hundred thirty‐seven LT were performed in 313 patients (09/88–12/92). Impact on long‐term outcome was studied and a comparison...
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| Veröffentlicht in: | American journal of transplantation 2013-09, Vol.13 (9), p.2384-2394 |
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| creator | Schoening, W. N. Buescher, N. Rademacher, S. Andreou, A. Kuehn, S. Neuhaus, R. Guckelberger, O. Puhl, G. Seehofer, D. Neuhaus, P. |
| description | With excellent short‐term survival in liver transplantation (LT), we now focus on long‐term outcome and report the first European single‐center 20‐year survival data. Three hundred thirty‐seven LT were performed in 313 patients (09/88–12/92). Impact on long‐term outcome was studied and a comparison to life expectancy of matched normal population was performed. A detailed analysis of 20‐years follow‐up concerning overweight (HBMI), hypertension (HTN), diabetes (HGL), hyperlipidemia (HLIP) and moderately or severely impaired renal function (MIRF, SIRF) is presented. Patient and graft survival at 1, 10, 20 years were 88.4%, 72.7%, 52.5% and 83.7%, 64.7% and 46.6%, respectively. Excluding 1‐year mortality, survival in the elderly LT recipients was similar to normal population. Primary indication (p |
| doi_str_mv | 10.1111/ajt.12384 |
| format | Article |
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This paper reports on European single‐center 20‐year survival data after liver transplantation with a detailed analysis of impact on long‐term outcome, causes of death, comorbidities and life expectancy in comparison to gender and age‐matched normal population.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.12384</identifier><identifier>PMID: 23915357</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Body Mass Index ; Female ; Follow-Up Studies ; Germany - epidemiology ; Graft Survival ; Humans ; Hyperlipidemias - epidemiology ; Hypertension - epidemiology ; Immunosuppression Therapy - adverse effects ; Kidney Diseases - epidemiology ; Life expectancy ; Liver transplantation ; Liver Transplantation - mortality ; Liver, biliary tract, pancreas, portal circulation, spleen ; long‐term outcome ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Mortality ; Reoperation - statistics & numerical data ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Transplants & implants</subject><ispartof>American journal of transplantation, 2013-09, Vol.13 (9), p.2384-2394</ispartof><rights>Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>2014 INIST-CNRS</rights><rights>Copyright 2013 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4514-c829f22dde1b67918630fa45ae475b2d19d376e2b3f2e00defef5ce861ff99743</citedby><cites>FETCH-LOGICAL-c4514-c829f22dde1b67918630fa45ae475b2d19d376e2b3f2e00defef5ce861ff99743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.12384$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.12384$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27864153$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23915357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schoening, W. N.</creatorcontrib><creatorcontrib>Buescher, N.</creatorcontrib><creatorcontrib>Rademacher, S.</creatorcontrib><creatorcontrib>Andreou, A.</creatorcontrib><creatorcontrib>Kuehn, S.</creatorcontrib><creatorcontrib>Neuhaus, R.</creatorcontrib><creatorcontrib>Guckelberger, O.</creatorcontrib><creatorcontrib>Puhl, G.</creatorcontrib><creatorcontrib>Seehofer, D.</creatorcontrib><creatorcontrib>Neuhaus, P.</creatorcontrib><title>Twenty‐Year Longitudinal Follow‐Up After Orthotopic Liver Transplantation: A Single‐Center Experience of 313 Consecutive Cases</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>With excellent short‐term survival in liver transplantation (LT), we now focus on long‐term outcome and report the first European single‐center 20‐year survival data. Three hundred thirty‐seven LT were performed in 313 patients (09/88–12/92). Impact on long‐term outcome was studied and a comparison to life expectancy of matched normal population was performed. A detailed analysis of 20‐years follow‐up concerning overweight (HBMI), hypertension (HTN), diabetes (HGL), hyperlipidemia (HLIP) and moderately or severely impaired renal function (MIRF, SIRF) is presented. Patient and graft survival at 1, 10, 20 years were 88.4%, 72.7%, 52.5% and 83.7%, 64.7% and 46.6%, respectively. Excluding 1‐year mortality, survival in the elderly LT recipients was similar to normal population. Primary indication (p < 0.001), age (p < 0.001), gender (p = 0.017), impaired renal function at 6 months (p < 0.001) and retransplantation (p = 0.034) had significant impact on patient survival. Recurrent disease (21.3%), infection (20.6%) and de novo malignancy (19.9%) were the most common causes of death. Prevalence of HTN (57.3–85.2%, p < 0.001), MIRF (41.8–55.2%, p = 0.01) and HBMI (33.2–45%, p = 0.014) increased throughout follow‐up, while prevalence of HLIP (78.0–47.6%, p < 0.001) declined. LT has conquered many barriers to achieve these outstanding long‐term results. However, much work is needed to combat recurrent disease and side effects of immunosuppression (IS).
This paper reports on European single‐center 20‐year survival data after liver transplantation with a detailed analysis of impact on long‐term outcome, causes of death, comorbidities and life expectancy in comparison to gender and age‐matched normal population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Germany - epidemiology</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Hyperlipidemias - epidemiology</subject><subject>Hypertension - epidemiology</subject><subject>Immunosuppression Therapy - adverse effects</subject><subject>Kidney Diseases - epidemiology</subject><subject>Life expectancy</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - mortality</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>long‐term outcome</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Reoperation - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). 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N.</creator><creator>Buescher, N.</creator><creator>Rademacher, S.</creator><creator>Andreou, A.</creator><creator>Kuehn, S.</creator><creator>Neuhaus, R.</creator><creator>Guckelberger, O.</creator><creator>Puhl, G.</creator><creator>Seehofer, D.</creator><creator>Neuhaus, P.</creator><general>Wiley</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201309</creationdate><title>Twenty‐Year Longitudinal Follow‐Up After Orthotopic Liver Transplantation: A Single‐Center Experience of 313 Consecutive Cases</title><author>Schoening, W. N. ; Buescher, N. ; Rademacher, S. ; Andreou, A. ; Kuehn, S. ; Neuhaus, R. ; Guckelberger, O. ; Puhl, G. ; Seehofer, D. ; Neuhaus, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4514-c829f22dde1b67918630fa45ae475b2d19d376e2b3f2e00defef5ce861ff99743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Germany - epidemiology</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Hyperlipidemias - epidemiology</topic><topic>Hypertension - epidemiology</topic><topic>Immunosuppression Therapy - adverse effects</topic><topic>Kidney Diseases - epidemiology</topic><topic>Life expectancy</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - mortality</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>long‐term outcome</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Reoperation - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). 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N.</creatorcontrib><creatorcontrib>Buescher, N.</creatorcontrib><creatorcontrib>Rademacher, S.</creatorcontrib><creatorcontrib>Andreou, A.</creatorcontrib><creatorcontrib>Kuehn, S.</creatorcontrib><creatorcontrib>Neuhaus, R.</creatorcontrib><creatorcontrib>Guckelberger, O.</creatorcontrib><creatorcontrib>Puhl, G.</creatorcontrib><creatorcontrib>Seehofer, D.</creatorcontrib><creatorcontrib>Neuhaus, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schoening, W. N.</au><au>Buescher, N.</au><au>Rademacher, S.</au><au>Andreou, A.</au><au>Kuehn, S.</au><au>Neuhaus, R.</au><au>Guckelberger, O.</au><au>Puhl, G.</au><au>Seehofer, D.</au><au>Neuhaus, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Twenty‐Year Longitudinal Follow‐Up After Orthotopic Liver Transplantation: A Single‐Center Experience of 313 Consecutive Cases</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2013-09</date><risdate>2013</risdate><volume>13</volume><issue>9</issue><spage>2384</spage><epage>2394</epage><pages>2384-2394</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>With excellent short‐term survival in liver transplantation (LT), we now focus on long‐term outcome and report the first European single‐center 20‐year survival data. Three hundred thirty‐seven LT were performed in 313 patients (09/88–12/92). Impact on long‐term outcome was studied and a comparison to life expectancy of matched normal population was performed. A detailed analysis of 20‐years follow‐up concerning overweight (HBMI), hypertension (HTN), diabetes (HGL), hyperlipidemia (HLIP) and moderately or severely impaired renal function (MIRF, SIRF) is presented. Patient and graft survival at 1, 10, 20 years were 88.4%, 72.7%, 52.5% and 83.7%, 64.7% and 46.6%, respectively. Excluding 1‐year mortality, survival in the elderly LT recipients was similar to normal population. Primary indication (p < 0.001), age (p < 0.001), gender (p = 0.017), impaired renal function at 6 months (p < 0.001) and retransplantation (p = 0.034) had significant impact on patient survival. Recurrent disease (21.3%), infection (20.6%) and de novo malignancy (19.9%) were the most common causes of death. Prevalence of HTN (57.3–85.2%, p < 0.001), MIRF (41.8–55.2%, p = 0.01) and HBMI (33.2–45%, p = 0.014) increased throughout follow‐up, while prevalence of HLIP (78.0–47.6%, p < 0.001) declined. LT has conquered many barriers to achieve these outstanding long‐term results. However, much work is needed to combat recurrent disease and side effects of immunosuppression (IS).
This paper reports on European single‐center 20‐year survival data after liver transplantation with a detailed analysis of impact on long‐term outcome, causes of death, comorbidities and life expectancy in comparison to gender and age‐matched normal population.</abstract><cop>Hoboken, NJ</cop><pub>Wiley</pub><pmid>23915357</pmid><doi>10.1111/ajt.12384</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Body Mass Index Female Follow-Up Studies Germany - epidemiology Graft Survival Humans Hyperlipidemias - epidemiology Hypertension - epidemiology Immunosuppression Therapy - adverse effects Kidney Diseases - epidemiology Life expectancy Liver transplantation Liver Transplantation - mortality Liver, biliary tract, pancreas, portal circulation, spleen long‐term outcome Male Medical sciences Medical treatment Middle Aged Mortality Reoperation - statistics & numerical data Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Transplants & implants |
| title | Twenty‐Year Longitudinal Follow‐Up After Orthotopic Liver Transplantation: A Single‐Center Experience of 313 Consecutive Cases |
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