Mtss1 is a critical epigenetically regulated tumor suppressor in CML

Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis,...

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Veröffentlicht in:	Leukemia 2016-04, Vol.30 (4), p.823-832
Hauptverfasser:	Schemionek, M, Herrmann, O, Reher, M M, Chatain, N, Schubert, C, Costa, I G, Hänzelmann, S, Gusmao, E G, Kintsler, S, Braunschweig, T, Hamilton, A, Helgason, G V, Copland, M, Schwab, A, Müller-Tidow, C, Li, S, Holyoake, T L, Brümmendorf, T H, Koschmieder, S
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/109 13/21 14 14/19 631/208/176/1988 631/67/1059/602 631/67/581 631/67/71 64/110 692/699/67/1990/283/1896 Animals Apoptosis BCR-ABL protein Binding sites Blotting, Western Bone marrow Bone tumors Cancer Research Cell Movement Cell Proliferation Chromatin Immunoprecipitation Chronic myeloid leukemia CpG islands Critical Care Medicine Development and progression DNA methylation Enzyme inhibitors Fusion protein Fusion Proteins, bcr-abl - genetics Gene Expression Regulation, Leukemic Genetic aspects Genetic regulation Health aspects Hematology Hematopoietic stem cells Humans Intensive Internal Medicine Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemogenesis Medicine Medicine & Public Health Metastases Mice Mice, Inbred C3H Mice, Transgenic Microfilament Proteins - genetics Microfilament Proteins - metabolism Myeloid leukemia Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Oncology original-article Progenitor cells Properties Protein-tyrosine kinase Real-Time Polymerase Chain Reaction Remission Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Stem cell transplantation Stem cells Transcription factors Transgenic mice Tumor Cells, Cultured Tumor suppressor genes Tumors Tyrosine Xenograft Model Antitumor Assays
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