Interferon-alpha for the therapy of myeloproliferative neoplasms: targeting the malignant clone

Interferon alpha (IFN-α) has been used for over 30 years to treat myeloproliferative neoplasms (MPNs). IFN-α was shown to induce clinical, hematological, molecular and histopathological responses in small clinical studies. Such combined efficacy has never been achieved with any other drug to date in...

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Veröffentlicht in:	Leukemia 2016-04, Vol.30 (4), p.776-781
Hauptverfasser:	Kiladjian, J-J, Giraudier, S, Cassinat, B
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 631/67/1990/2331 64/60 692/699/67/580/1884 692/700/565 692/700/565/1331 Antiviral Agents - therapeutic use Biological properties Calreticulin Cancer Research Critical Care Medicine Drug therapy Hematology Humans Hydroxyurea Immune response Immunological tolerance Intensive Interferon Interferon alpha Interferon-alpha - therapeutic use Internal Medicine Medicine Medicine & Public Health Methods Molecular targeted therapy Mutation Myeloproliferative disorders Myeloproliferative Disorders - drug therapy Neoplasms Oncology Patient outcomes review Stem cells Toxicity Tumors α-Interferon
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