Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation
Aims To evaluate the clinical efficacy of bariatric surgery vs medical therapy with liraglutide on weight loss, glycemic control and cardiovascular risk profile in patients with type 2 diabetes and severe obesity. Methods A retrospective evaluation was conducted in 31 patients with type 2 diabetes a...
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| Veröffentlicht in: | Acta diabetologica 2015-04, Vol.52 (2), p.331-336 |
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| creator | Cotugno, M. Nosso, G. Saldalamacchia, G. Vitagliano, G. Griffo, E. Lupoli, R. Angrisani, L. Riccardi, G. Capaldo, B. |
| description | Aims
To evaluate the clinical efficacy of bariatric surgery
vs
medical therapy with liraglutide on weight loss, glycemic control and cardiovascular risk profile in patients with type 2 diabetes and severe obesity.
Methods
A retrospective evaluation was conducted in 31 patients with type 2 diabetes and severe obesity who had undergone bariatric surgery and in 31 patients with type 2 diabetes and comparable body weight who had added liraglutide to their background medical treatment in the period 2009–2013. Anthropometric parameters, glycemic control, treatment of diabetes and other comorbidities, safety and side effects before and 12 months after treatment were assessed.
Results
Age was 47 ± 8 years (mean ± SD) in bariatric surgery and 56 ± 9 years in medical treatment group (
p
|
| doi_str_mv | 10.1007/s00592-014-0644-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1785237455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1785237455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-9bd7e2ab55d398ff26d75272f36ad876f0095b0f50c2a0d6307d2d358e8759d73</originalsourceid><addsrcrecordid>eNqFkc-KFDEQh4Mo7rj6AF4k4MVLa-V_tzcZ1F1Y8KLnJt2prFl60m2SHunX8InNMKuIIJ7qkK9-VamPkOcMXjMA8yYDqI43wGQDWspGPSA7JgVvFBfiIdlBJ6FRkncX5EnOdwCMG9E-JhdccdZ2XO7Ij_0UYhjtRNH7WseNzp4ONgVbUhhpXtMtpo0eMeU10ykkezutJTikIdLFloCxZPo9lK-0bAtSTl2wAxbM1EZHM9ZOpPOAOZTtLbWU8eYwx4onLGnOC44lHJHi0U5rjZvjU_LI2ynjs_t6Sb58eP95f9XcfPp4vX9304wSVGm6wRnkdlDKia71nmtnFDfcC21da7QH6NQAXsHILTgtwDjuhGqxNapzRlySV-fcJc3fVsylP4Q84jTZiPOae2baekcjlfo_qrURUjPOK_ryL_RuXlOsHzlRLWgttawUO1NjPUFO6PslhYNNW8-gP7ntz2776rY_ue1PS7y4T16HA7rfHb9kVoCfgVyfYtX2x-h_pv4ETmKv0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1668066464</pqid></control><display><type>article</type><title>Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Cotugno, M. ; Nosso, G. ; Saldalamacchia, G. ; Vitagliano, G. ; Griffo, E. ; Lupoli, R. ; Angrisani, L. ; Riccardi, G. ; Capaldo, B.</creator><creatorcontrib>Cotugno, M. ; Nosso, G. ; Saldalamacchia, G. ; Vitagliano, G. ; Griffo, E. ; Lupoli, R. ; Angrisani, L. ; Riccardi, G. ; Capaldo, B.</creatorcontrib><description>Aims
To evaluate the clinical efficacy of bariatric surgery
vs
medical therapy with liraglutide on weight loss, glycemic control and cardiovascular risk profile in patients with type 2 diabetes and severe obesity.
Methods
A retrospective evaluation was conducted in 31 patients with type 2 diabetes and severe obesity who had undergone bariatric surgery and in 31 patients with type 2 diabetes and comparable body weight who had added liraglutide to their background medical treatment in the period 2009–2013. Anthropometric parameters, glycemic control, treatment of diabetes and other comorbidities, safety and side effects before and 12 months after treatment were assessed.
Results
Age was 47 ± 8 years (mean ± SD) in bariatric surgery and 56 ± 9 years in medical treatment group (
p
< 0.001); body mass index before treatment was 44 ± 7 and 40 ± 4 kg/m
2
in bariatric surgery and medical treatment, respectively (
p
= 0.03). Twelve months after treatment, average weight loss was 38 ± 15 kg among bariatric surgery patients, and 5 ± 8 kg in medical treatment group (
p
< 0.001). Glycemic control improved in both groups with greater improvement in bariatric surgery patients. The UKPDS risk score decreased in both groups, although it remained higher in medical treatment than in bariatric surgery patients (
p
< 0.001). Of note, almost 60 % of patients on liraglutide met the target of glycated hemoglobin <7 % (53 mmol/mol) and lost ≥5 % of body weight.
Conclusions
In severely obese type 2 diabetic patients, bariatric surgery reduced body weight and improved overall metabolic control to a greater extent than medical treatment. Randomized clinical studies are necessary.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-014-0644-5</identifier><identifier>PMID: 25218924</identifier><identifier>CODEN: ACDAEZ</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Aged ; Bariatric Surgery ; Blood Glucose - metabolism ; Diabetes ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes Mellitus, Type 2 - surgery ; Female ; Gastrointestinal surgery ; Glycated Hemoglobin A - metabolism ; Humans ; Hypoglycemic Agents - therapeutic use ; Internal Medicine ; Liraglutide - therapeutic use ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Obesity ; Obesity, Morbid - drug therapy ; Obesity, Morbid - metabolism ; Obesity, Morbid - physiopathology ; Obesity, Morbid - surgery ; Original Article ; Retrospective Studies ; Treatment Outcome ; Weight control ; Weight Loss</subject><ispartof>Acta diabetologica, 2015-04, Vol.52 (2), p.331-336</ispartof><rights>Springer-Verlag Italia 2014</rights><rights>Springer-Verlag Italia 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-9bd7e2ab55d398ff26d75272f36ad876f0095b0f50c2a0d6307d2d358e8759d73</citedby><cites>FETCH-LOGICAL-c405t-9bd7e2ab55d398ff26d75272f36ad876f0095b0f50c2a0d6307d2d358e8759d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00592-014-0644-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00592-014-0644-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25218924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cotugno, M.</creatorcontrib><creatorcontrib>Nosso, G.</creatorcontrib><creatorcontrib>Saldalamacchia, G.</creatorcontrib><creatorcontrib>Vitagliano, G.</creatorcontrib><creatorcontrib>Griffo, E.</creatorcontrib><creatorcontrib>Lupoli, R.</creatorcontrib><creatorcontrib>Angrisani, L.</creatorcontrib><creatorcontrib>Riccardi, G.</creatorcontrib><creatorcontrib>Capaldo, B.</creatorcontrib><title>Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Aims
To evaluate the clinical efficacy of bariatric surgery
vs
medical therapy with liraglutide on weight loss, glycemic control and cardiovascular risk profile in patients with type 2 diabetes and severe obesity.
Methods
A retrospective evaluation was conducted in 31 patients with type 2 diabetes and severe obesity who had undergone bariatric surgery and in 31 patients with type 2 diabetes and comparable body weight who had added liraglutide to their background medical treatment in the period 2009–2013. Anthropometric parameters, glycemic control, treatment of diabetes and other comorbidities, safety and side effects before and 12 months after treatment were assessed.
Results
Age was 47 ± 8 years (mean ± SD) in bariatric surgery and 56 ± 9 years in medical treatment group (
p
< 0.001); body mass index before treatment was 44 ± 7 and 40 ± 4 kg/m
2
in bariatric surgery and medical treatment, respectively (
p
= 0.03). Twelve months after treatment, average weight loss was 38 ± 15 kg among bariatric surgery patients, and 5 ± 8 kg in medical treatment group (
p
< 0.001). Glycemic control improved in both groups with greater improvement in bariatric surgery patients. The UKPDS risk score decreased in both groups, although it remained higher in medical treatment than in bariatric surgery patients (
p
< 0.001). Of note, almost 60 % of patients on liraglutide met the target of glycated hemoglobin <7 % (53 mmol/mol) and lost ≥5 % of body weight.
Conclusions
In severely obese type 2 diabetic patients, bariatric surgery reduced body weight and improved overall metabolic control to a greater extent than medical treatment. Randomized clinical studies are necessary.</description><subject>Adult</subject><subject>Aged</subject><subject>Bariatric Surgery</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - surgery</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Internal Medicine</subject><subject>Liraglutide - therapeutic use</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - drug therapy</subject><subject>Obesity, Morbid - metabolism</subject><subject>Obesity, Morbid - physiopathology</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Article</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Weight control</subject><subject>Weight Loss</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkc-KFDEQh4Mo7rj6AF4k4MVLa-V_tzcZ1F1Y8KLnJt2prFl60m2SHunX8InNMKuIIJ7qkK9-VamPkOcMXjMA8yYDqI43wGQDWspGPSA7JgVvFBfiIdlBJ6FRkncX5EnOdwCMG9E-JhdccdZ2XO7Ij_0UYhjtRNH7WseNzp4ONgVbUhhpXtMtpo0eMeU10ykkezutJTikIdLFloCxZPo9lK-0bAtSTl2wAxbM1EZHM9ZOpPOAOZTtLbWU8eYwx4onLGnOC44lHJHi0U5rjZvjU_LI2ynjs_t6Sb58eP95f9XcfPp4vX9304wSVGm6wRnkdlDKia71nmtnFDfcC21da7QH6NQAXsHILTgtwDjuhGqxNapzRlySV-fcJc3fVsylP4Q84jTZiPOae2baekcjlfo_qrURUjPOK_ryL_RuXlOsHzlRLWgttawUO1NjPUFO6PslhYNNW8-gP7ntz2776rY_ue1PS7y4T16HA7rfHb9kVoCfgVyfYtX2x-h_pv4ETmKv0A</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Cotugno, M.</creator><creator>Nosso, G.</creator><creator>Saldalamacchia, G.</creator><creator>Vitagliano, G.</creator><creator>Griffo, E.</creator><creator>Lupoli, R.</creator><creator>Angrisani, L.</creator><creator>Riccardi, G.</creator><creator>Capaldo, B.</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation</title><author>Cotugno, M. ; Nosso, G. ; Saldalamacchia, G. ; Vitagliano, G. ; Griffo, E. ; Lupoli, R. ; Angrisani, L. ; Riccardi, G. ; Capaldo, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-9bd7e2ab55d398ff26d75272f36ad876f0095b0f50c2a0d6307d2d358e8759d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bariatric Surgery</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - surgery</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Internal Medicine</topic><topic>Liraglutide - therapeutic use</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - drug therapy</topic><topic>Obesity, Morbid - metabolism</topic><topic>Obesity, Morbid - physiopathology</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Article</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Weight control</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cotugno, M.</creatorcontrib><creatorcontrib>Nosso, G.</creatorcontrib><creatorcontrib>Saldalamacchia, G.</creatorcontrib><creatorcontrib>Vitagliano, G.</creatorcontrib><creatorcontrib>Griffo, E.</creatorcontrib><creatorcontrib>Lupoli, R.</creatorcontrib><creatorcontrib>Angrisani, L.</creatorcontrib><creatorcontrib>Riccardi, G.</creatorcontrib><creatorcontrib>Capaldo, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cotugno, M.</au><au>Nosso, G.</au><au>Saldalamacchia, G.</au><au>Vitagliano, G.</au><au>Griffo, E.</au><au>Lupoli, R.</au><au>Angrisani, L.</au><au>Riccardi, G.</au><au>Capaldo, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>52</volume><issue>2</issue><spage>331</spage><epage>336</epage><pages>331-336</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><coden>ACDAEZ</coden><abstract>Aims
To evaluate the clinical efficacy of bariatric surgery
vs
medical therapy with liraglutide on weight loss, glycemic control and cardiovascular risk profile in patients with type 2 diabetes and severe obesity.
Methods
A retrospective evaluation was conducted in 31 patients with type 2 diabetes and severe obesity who had undergone bariatric surgery and in 31 patients with type 2 diabetes and comparable body weight who had added liraglutide to their background medical treatment in the period 2009–2013. Anthropometric parameters, glycemic control, treatment of diabetes and other comorbidities, safety and side effects before and 12 months after treatment were assessed.
Results
Age was 47 ± 8 years (mean ± SD) in bariatric surgery and 56 ± 9 years in medical treatment group (
p
< 0.001); body mass index before treatment was 44 ± 7 and 40 ± 4 kg/m
2
in bariatric surgery and medical treatment, respectively (
p
= 0.03). Twelve months after treatment, average weight loss was 38 ± 15 kg among bariatric surgery patients, and 5 ± 8 kg in medical treatment group (
p
< 0.001). Glycemic control improved in both groups with greater improvement in bariatric surgery patients. The UKPDS risk score decreased in both groups, although it remained higher in medical treatment than in bariatric surgery patients (
p
< 0.001). Of note, almost 60 % of patients on liraglutide met the target of glycated hemoglobin <7 % (53 mmol/mol) and lost ≥5 % of body weight.
Conclusions
In severely obese type 2 diabetic patients, bariatric surgery reduced body weight and improved overall metabolic control to a greater extent than medical treatment. Randomized clinical studies are necessary.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>25218924</pmid><doi>10.1007/s00592-014-0644-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-5429 |
| ispartof | Acta diabetologica, 2015-04, Vol.52 (2), p.331-336 |
| issn | 0940-5429 1432-5233 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1785237455 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Bariatric Surgery Blood Glucose - metabolism Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetes Mellitus, Type 2 - surgery Female Gastrointestinal surgery Glycated Hemoglobin A - metabolism Humans Hypoglycemic Agents - therapeutic use Internal Medicine Liraglutide - therapeutic use Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Obesity Obesity, Morbid - drug therapy Obesity, Morbid - metabolism Obesity, Morbid - physiopathology Obesity, Morbid - surgery Original Article Retrospective Studies Treatment Outcome Weight control Weight Loss |
| title | Clinical efficacy of bariatric surgery versus liraglutide in patients with type 2 diabetes and severe obesity: a 12-month retrospective evaluation |
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