Stability of a Vesicular Stomatitis Virus–Vectored Ebola Vaccine
The live attenuated vesicular stomatitis virus–vectored Ebola vaccine rVSV-ZEBOV is currently undergoing clinical trials in West Africa. The vaccine is to be stored at −70°C or less. Since maintaining the cold chain is challenging in rural areas, the rVSV-ZEBOV vaccine's short-term and long-ter...
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| Veröffentlicht in: | The Journal of infectious diseases 2016-03, Vol.213 (6), p.930-933 |
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| container_title | The Journal of infectious diseases |
| container_volume | 213 |
| creator | Arnemo, Marianne Watle, Sara Sofie Viksmoen Schoultz, Kristin Merete Vainio, Kirsti Norheim, Gunnstein Moorthy, Vasee Fast, Patricia Røttingen, John-Arne Gjøen, Tor |
| description | The live attenuated vesicular stomatitis virus–vectored Ebola vaccine rVSV-ZEBOV is currently undergoing clinical trials in West Africa. The vaccine is to be stored at −70°C or less. Since maintaining the cold chain is challenging in rural areas, the rVSV-ZEBOV vaccine's short-term and long-term stability at different temperatures was examined. Different dilutions were tested since the optimal vaccine dosage had not yet been determined at the start of this experiment. The results demonstrate that the original vaccine formulation was stable for 1 week at 4°C and for 24 hours at 25°C. The stability of the vaccine was compromised by both high temperatures and dilution. |
| doi_str_mv | 10.1093/infdis/jiv532 |
| format | Article |
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The vaccine is to be stored at −70°C or less. Since maintaining the cold chain is challenging in rural areas, the rVSV-ZEBOV vaccine's short-term and long-term stability at different temperatures was examined. Different dilutions were tested since the optimal vaccine dosage had not yet been determined at the start of this experiment. The results demonstrate that the original vaccine formulation was stable for 1 week at 4°C and for 24 hours at 25°C. The stability of the vaccine was compromised by both high temperatures and dilution.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiv532</identifier><identifier>PMID: 26563239</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Animals ; Chlorocebus aethiops ; Ebola Vaccines - chemistry ; Ebola virus ; Hydrogen-Ion Concentration ; Temperature ; Time Factors ; Vaccine Potency ; Vero Cells ; VIRUSES</subject><ispartof>The Journal of infectious diseases, 2016-03, Vol.213 (6), p.930-933</ispartof><rights>Copyright © 2016 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-739a140098bf85632a5c7585efc6432802bb9d91f1f1c69cb384b575e0c782c3</citedby><cites>FETCH-LOGICAL-c387t-739a140098bf85632a5c7585efc6432802bb9d91f1f1c69cb384b575e0c782c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24716566$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24716566$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26563239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arnemo, Marianne</creatorcontrib><creatorcontrib>Watle, Sara Sofie Viksmoen</creatorcontrib><creatorcontrib>Schoultz, Kristin Merete</creatorcontrib><creatorcontrib>Vainio, Kirsti</creatorcontrib><creatorcontrib>Norheim, Gunnstein</creatorcontrib><creatorcontrib>Moorthy, Vasee</creatorcontrib><creatorcontrib>Fast, Patricia</creatorcontrib><creatorcontrib>Røttingen, John-Arne</creatorcontrib><creatorcontrib>Gjøen, Tor</creatorcontrib><title>Stability of a Vesicular Stomatitis Virus–Vectored Ebola Vaccine</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The live attenuated vesicular stomatitis virus–vectored Ebola vaccine rVSV-ZEBOV is currently undergoing clinical trials in West Africa. 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The stability of the vaccine was compromised by both high temperatures and dilution.</description><subject>Animals</subject><subject>Chlorocebus aethiops</subject><subject>Ebola Vaccines - chemistry</subject><subject>Ebola virus</subject><subject>Hydrogen-Ion Concentration</subject><subject>Temperature</subject><subject>Time Factors</subject><subject>Vaccine Potency</subject><subject>Vero Cells</subject><subject>VIRUSES</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0LtOwzAUgGELgWgpjIygjCyhvsS3EapykSoxtOoa2Y4juUqaYjtIbLwDb8iT4CoFVuTBg79zLP0AXCJ4i6AkU7etKxemG_dGCT4CY0QJzxlD5BiMIcQ4R0LKETgLYQMhLAjjp2CEGWUEEzkG98uotGtcfM-6OlPZ2gZn-kb5bBm7VkUXXcjWzvfh6-NzbU3svK2yue6aZJUxbmvPwUmtmmAvDvcErB7mq9lTvnh5fJ7dLXJDBI85J1KhAkIpdC323ytqOBXU1oYVBAuItZaVRHU6hkmjiSg05dRCwwU2ZAJuhrU73732NsSydcHYplFb2_WhRFxQTBjl8B-UCcR4mkg0H6jxXQje1uXOu1b59xLBch-4HAKXQ-Dkrw-re93a6lf_FE3gagCbkFr9vRccJcLIN9rogcE</recordid><startdate>20160315</startdate><enddate>20160315</enddate><creator>Arnemo, Marianne</creator><creator>Watle, Sara Sofie Viksmoen</creator><creator>Schoultz, Kristin Merete</creator><creator>Vainio, Kirsti</creator><creator>Norheim, Gunnstein</creator><creator>Moorthy, Vasee</creator><creator>Fast, Patricia</creator><creator>Røttingen, John-Arne</creator><creator>Gjøen, Tor</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20160315</creationdate><title>Stability of a Vesicular Stomatitis Virus–Vectored Ebola Vaccine</title><author>Arnemo, Marianne ; Watle, Sara Sofie Viksmoen ; Schoultz, Kristin Merete ; Vainio, Kirsti ; Norheim, Gunnstein ; Moorthy, Vasee ; Fast, Patricia ; Røttingen, John-Arne ; Gjøen, Tor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-739a140098bf85632a5c7585efc6432802bb9d91f1f1c69cb384b575e0c782c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Chlorocebus aethiops</topic><topic>Ebola Vaccines - chemistry</topic><topic>Ebola virus</topic><topic>Hydrogen-Ion Concentration</topic><topic>Temperature</topic><topic>Time Factors</topic><topic>Vaccine Potency</topic><topic>Vero Cells</topic><topic>VIRUSES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arnemo, Marianne</creatorcontrib><creatorcontrib>Watle, Sara Sofie Viksmoen</creatorcontrib><creatorcontrib>Schoultz, Kristin Merete</creatorcontrib><creatorcontrib>Vainio, Kirsti</creatorcontrib><creatorcontrib>Norheim, Gunnstein</creatorcontrib><creatorcontrib>Moorthy, Vasee</creatorcontrib><creatorcontrib>Fast, Patricia</creatorcontrib><creatorcontrib>Røttingen, John-Arne</creatorcontrib><creatorcontrib>Gjøen, Tor</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arnemo, Marianne</au><au>Watle, Sara Sofie Viksmoen</au><au>Schoultz, Kristin Merete</au><au>Vainio, Kirsti</au><au>Norheim, Gunnstein</au><au>Moorthy, Vasee</au><au>Fast, Patricia</au><au>Røttingen, John-Arne</au><au>Gjøen, Tor</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stability of a Vesicular Stomatitis Virus–Vectored Ebola Vaccine</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2016-03-15</date><risdate>2016</risdate><volume>213</volume><issue>6</issue><spage>930</spage><epage>933</epage><pages>930-933</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>The live attenuated vesicular stomatitis virus–vectored Ebola vaccine rVSV-ZEBOV is currently undergoing clinical trials in West Africa. 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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Chlorocebus aethiops Ebola Vaccines - chemistry Ebola virus Hydrogen-Ion Concentration Temperature Time Factors Vaccine Potency Vero Cells VIRUSES |
| title | Stability of a Vesicular Stomatitis Virus–Vectored Ebola Vaccine |
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