Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis in Streptomyces graminofaciens A-8890

To isolate a key polyketide biosynthetic intermediate for the 16‐membered macrolide FD‐891 (1), we inactivated two biosynthetic genes coding for post‐polyketide synthase (PKS) modification enzymes: a methyltransferase (GfsG) and a cytochrome P450 (GfsF). Consequently, FD‐892 (2), which lacks the epo...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-02, Vol.17 (3), p.233-238
Hauptverfasser:	Kudo, Fumitaka, Kawamura, Koichi, Furuya, Takashi, Yamanishi, Hiroto, Motegi, Atsushi, Komatsubara, Akiko, Numakura, Mario, Miyanaga, Akimasa, Eguchi, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	antibiotics Biosynthesis Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Epoxy Compounds - chemistry Hydroxylation Kinetics Macrolides - chemistry Macrolides - metabolism Methylation methyltransferases Methyltransferases - metabolism Multigene Family Mutagenesis, Site-Directed natural products Polyketide Synthases - genetics Polyketide Synthases - metabolism polyketides Streptomyces Streptomyces - enzymology
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