The evolution of T‐cell depletion in haploidentical stem‐cell transplantation

Summary T‐cell depletion (TCD) can prevent the onset of graft‐versus‐host disease (GvHD) in animal models of bone marrow transplantation; this manipulation enabled the successful application in the 1980s of T‐cell depleted bone marrow (BM) for the treatment of babies with severe combined immune defi...

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Veröffentlicht in:	British journal of haematology 2016-03, Vol.172 (5), p.667-684
Hauptverfasser:	Or‐Geva, Noga, Reisner, Yair
Format:	Artikel
Sprache:	eng
Schlagworte:	anti‐third‐party CD8+ Tcm graft anti‐tumour Graft Rejection - immunology Graft vs Host Disease - immunology Graft vs Host Disease - prevention & control graft‐versus host disease Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - trends Humans Immunotherapy, Adoptive - methods Lymphocyte Depletion - methods nonmyeloablative/reduced conditioning T-Lymphocytes - immunology Transplantation Conditioning - methods veto cell
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