Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome
Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association h...
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| Veröffentlicht in: | Pediatric blood & cancer 2016-03, Vol.63 (3), p.544-546 |
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| container_issue | 3 |
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| container_title | Pediatric blood & cancer |
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| creator | Hagelstrom, Robert Tanner Ford, James Reiser, Gwendolyn M. Nelson, Marilu Pickering, Diane L. Althof, Pamela A. Sanger, Warren G. Coccia, Peter F. |
| description | Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B‐cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy. |
| doi_str_mv | 10.1002/pbc.25796 |
| format | Article |
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Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). 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We describe a patient with Cowden syndrome who was initially diagnosed with B‐cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.</description><subject>Adult</subject><subject>B-cell lymphoblastic lymphoma</subject><subject>Breast cancer</subject><subject>Breast Neoplasms, Male - complications</subject><subject>Cancer therapies</subject><subject>Child</subject><subject>Cowden syndrome</subject><subject>Hamartoma Syndrome, Multiple - complications</subject><subject>Hamartoma Syndrome, Multiple - genetics</subject><subject>Hematology</subject><subject>Humans</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - complications</subject><subject>Male</subject><subject>male breast cancer</subject><subject>Oncology</subject><subject>Pediatrics</subject><subject>Pedigree</subject><subject>PTEN</subject><issn>1545-5009</issn><issn>1545-5017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0TlPwzAYBmALgbgH_gCyxMIS8BFfI42gHOUQhxCT5TgOBBK7JI1K_z2GQgcmJr-Sn9eSvw-AHYwOMELkcJzbA8KE4ktgHbOUJQxhsbzISK2Bja57jZQjJlfBGuEplzxF6-Bi0DrTTWBmvHUtNL6AV8Enp6F4fqs8HM2a8UtoDIzZwKfQ-2d4aWoHp9XkBWZhWjgP72a-aEPjtsBKaerObf-cm-Dh5Pg-O01G18Oz7GiUWE4ZT2SJKTYUc6O4TVUhZG4KJamlUpFSlJjkNC95iTFSeWqpwM6WJM1tTikukaWbYH_-7rgN773rJrqpOuvq2ngX-k5jIRmhhCvxD8qRwkRSFuneH_oa-tbHj0TFJMdKCR7V7o_q88YVetxWjWln-neiERzOwbSq3Wxxj5H-WpWOq9Lfq9I3g-w7xEYyb1TdxH0sGqZ901xQwfTj1VAPbtNRen5_rin9BG23kcQ</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Hagelstrom, Robert Tanner</creator><creator>Ford, James</creator><creator>Reiser, Gwendolyn M.</creator><creator>Nelson, Marilu</creator><creator>Pickering, Diane L.</creator><creator>Althof, Pamela A.</creator><creator>Sanger, Warren G.</creator><creator>Coccia, Peter F.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome</title><author>Hagelstrom, Robert Tanner ; 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| subjects | Adult B-cell lymphoblastic lymphoma Breast cancer Breast Neoplasms, Male - complications Cancer therapies Child Cowden syndrome Hamartoma Syndrome, Multiple - complications Hamartoma Syndrome, Multiple - genetics Hematology Humans Lymphoma Lymphoma, Non-Hodgkin - complications Male male breast cancer Oncology Pediatrics Pedigree PTEN |
| title | Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome |
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