Factors of Th17 and Treg Lymphocyte Differentiation in Pulmonary Tuberculosis

In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4 + CD161 +...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.201-204
Hauptverfasser:	Kononova, T. E., Urazova, O. I., Novitskii, V. V., Kolobovnikova, Yu. V., Churina, E. G., Zakharova, P. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine CD4 Antigens - metabolism Cell Biology Cell Differentiation - immunology Drug resistance Female Forkhead Transcription Factors - metabolism Humans Interleukin-2 Receptor alpha Subunit - metabolism Internal Medicine Laboratory Medicine Male Middle Aged Mycobacterium NK Cell Lectin-Like Receptor Subfamily B - metabolism Pathology Pulmonary tuberculosis Statistics, Nonparametric T cells T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th17 Cells - immunology Th17 Cells - metabolism Transforming Growth Factor beta - immunology Transforming growth factors Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - immunology
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Zusammenfassung:	In patients with infiltrative pulmonary tuberculosis, the increase in IL-6 secretion, the decrease in TGFβ production (in case of drug resistance of the causative agent), and unchanged level of IL-1β secretion by mononuclear leukocytes in vitro were associated with increased number of CD4 + CD161 + IL-17A + Th17 lymphocytes in the peripheral blood. In patients with disseminated drug-resistant pulmonary tuberculosis, TGFβ hyperproduction promoted differentiation of CD4 + CD25 + FoxP3 + Treg lymphocytes with immunosuppressive activity.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-015-2922-9