Effect of Annexin V on Development of Apoptosis in Placental Syncytiotrophoblast Nuclei during Exacerbation of Cytomegalovirus Infection in the Third Trimester
During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to st...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016, Vol.160 (3), p.327-329 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Lutsenko, M. T. Andrievskaya, I. A. |
| description | During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to structural disturbances in DNA in syncytiotrophoblast nuclei and stimulates their apoptosis. Structural abnormalities in the syncytiotrophoblast during exacerbation of cytomegalovirus infection are dangerous for fetal development. |
| doi_str_mv | 10.1007/s10517-016-3162-3 |
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T.</creatorcontrib><creatorcontrib>Andrievskaya, I. A.</creatorcontrib><title>Effect of Annexin V on Development of Apoptosis in Placental Syncytiotrophoblast Nuclei during Exacerbation of Cytomegalovirus Infection in the Third Trimester</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>During exacerbation of cytomegalovirus infection during pregnancy, cytomegalovirus proteins penetrate across the external membrane of placental villous syncytiotrophoblast and suppress activities of ATPase and Bcl-2 protein. Simultaneous increase in the content of annexin V and caspase 3 leads to structural disturbances in DNA in syncytiotrophoblast nuclei and stimulates their apoptosis. Structural abnormalities in the syncytiotrophoblast during exacerbation of cytomegalovirus infection are dangerous for fetal development.</description><subject>Annexin A5 - metabolism</subject><subject>Annexins</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell Nucleus - metabolism</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus infections</subject><subject>Cytomegalovirus Infections - metabolism</subject><subject>Female</subject><subject>Fetus</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infection</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Pathology</subject><subject>Placenta - cytology</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third - metabolism</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Trophoblasts - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNklGL1DAQx4so3nn6AXyRgCC-9Mw0bZM-LnurHhwquPpa0nR6myNNatIet5_Gr2rCnnonChJIyMxv_sMM_yx7DvQUKOVvAtAKeE6hzhnURc4eZMdQcZaLooCH2TGNUF4KIY6yJyFcpS-t4XF2VNS8LHhFj7Pvm2FANRM3kJW1eKMt-UqcJWd4jcZNI9pDbnLT7IIOJAKfjFQxLg35vLdqP2s3ezftXGdkmMmHRRnUpF-8tpdkcxNZ38kI2SS03s9uxEtp3LX2SyDnNrVPySg875Bsd9r3ZOv1iGFG_zR7NEgT8Nnte5J9ebvZrt_nFx_fna9XF7kqq2rOC-hlxUD0XFBsatljxRuBQ9N1ig8Ceg4CGjbQrqQKmrJHBlI2yHhddAN07CR7fdCdvPu2xNbtqINCY6RFt4QWuKgKBlVR_QdaU5G6sYi-_AO9cou3cZBI8RI4owC_qbgWbLUd4j6lSqLtqixLRpt4Rer0L1Q8PY5aOYuDjvF7Ba_uFOxQmnkXnFnStsN9EA6g8i4Ej0M7xfVLv2-Btslo7cFobTRam4zWppoXt5Mt3Yj9r4qfzopAcQDClIyA_s7o_1T9AV1U3Ug</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Lutsenko, M. 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| subjects | Annexin A5 - metabolism Annexins Apoptosis Apoptosis - physiology Biomedical and Life Sciences Biomedicine Cell Biology Cell Nucleus - metabolism Cytomegalovirus Cytomegalovirus infections Cytomegalovirus Infections - metabolism Female Fetus Growth Health aspects Humans Infection Internal Medicine Laboratory Medicine Pathology Placenta - cytology Placenta - metabolism Pregnancy Pregnancy Trimester, Third - metabolism Protein binding Proteins Trophoblasts - metabolism |
| title | Effect of Annexin V on Development of Apoptosis in Placental Syncytiotrophoblast Nuclei during Exacerbation of Cytomegalovirus Infection in the Third Trimester |
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