Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone
We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological...
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| Veröffentlicht in: | Journal of dermatology 2016-02, Vol.43 (2), p.194-196 |
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| creator | Hosoda, Satomi Adachi, Akimasa Suzuki, Masayuki Yamada, Tomoko Komine, Mayumi Murata, Satoru Ohtsuki, Mamitaro |
| description | We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo‐bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti‐ICS IgG bound to desmoglein‐3, while the anti‐BMZ antibodies bound to the epidermal side of 1 mol/L NaCl‐split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo‐bound and circulating anti‐ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti‐ICS antibodies belonged to IgG1 and IgG4, while the circulating anti‐BMZ antibodies to IgG1, IgG2 and IgG4.
We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo‐bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti‐ICS IgG bound to desmoglein‐3, while the anti‐BMZ antibodies bound to the epidermal side of 1 mol/L NaCl‐split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo‐bound and circulating anti‐ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti‐ICS antibodies belonged to IgG1 and IgG4, while the circulating anti‐BMZ antibodies to IgG1, IgG2 and IgG4. |
| doi_str_mv | 10.1111/1346-8138.13041 |
| format | Article |
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We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo‐bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti‐ICS IgG bound to desmoglein‐3, while the anti‐BMZ antibodies bound to the epidermal side of 1 mol/L NaCl‐split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo‐bound and circulating anti‐ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti‐ICS antibodies belonged to IgG1 and IgG4, while the circulating anti‐BMZ antibodies to IgG1, IgG2 and IgG4.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.13041</identifier><identifier>PMID: 26219735</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Autoantibodies - blood ; Autoantibodies - classification ; Autoantibodies - metabolism ; Basement Membrane - immunology ; Basement Membrane - pathology ; Extracellular Space - immunology ; Female ; Humans ; Immunoglobulin A - metabolism ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Immunoglobulin G - metabolism ; immunoglobulin G subclass ; immunoglobulin G/A pemphigus ; linear immunoglobulin A bullous dermatosis ; Middle Aged ; pemphigoid ; pemphigus ; Pemphigus - immunology ; Pemphigus - pathology</subject><ispartof>Journal of dermatology, 2016-02, Vol.43 (2), p.194-196</ispartof><rights>2015 Japanese Dermatological Association</rights><rights>2015 Japanese Dermatological Association.</rights><rights>Copyright © 2016 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4661-6206c6f0da4ef77afe25ef81fed25e658082a128eda79bd0bd03f5887f2cacdb3</citedby><cites>FETCH-LOGICAL-c4661-6206c6f0da4ef77afe25ef81fed25e658082a128eda79bd0bd03f5887f2cacdb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.13041$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.13041$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26219735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosoda, Satomi</creatorcontrib><creatorcontrib>Adachi, Akimasa</creatorcontrib><creatorcontrib>Suzuki, Masayuki</creatorcontrib><creatorcontrib>Yamada, Tomoko</creatorcontrib><creatorcontrib>Komine, Mayumi</creatorcontrib><creatorcontrib>Murata, Satoru</creatorcontrib><creatorcontrib>Ohtsuki, Mamitaro</creatorcontrib><title>Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo‐bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti‐ICS IgG bound to desmoglein‐3, while the anti‐BMZ antibodies bound to the epidermal side of 1 mol/L NaCl‐split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo‐bound and circulating anti‐ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti‐ICS antibodies belonged to IgG1 and IgG4, while the circulating anti‐BMZ antibodies to IgG1, IgG2 and IgG4.
We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo‐bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti‐ICS IgG bound to desmoglein‐3, while the anti‐BMZ antibodies bound to the epidermal side of 1 mol/L NaCl‐split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo‐bound and circulating anti‐ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti‐ICS antibodies belonged to IgG1 and IgG4, while the circulating anti‐BMZ antibodies to IgG1, IgG2 and IgG4.</description><subject>Autoantibodies - blood</subject><subject>Autoantibodies - classification</subject><subject>Autoantibodies - metabolism</subject><subject>Basement Membrane - immunology</subject><subject>Basement Membrane - pathology</subject><subject>Extracellular Space - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - metabolism</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin G - metabolism</subject><subject>immunoglobulin G subclass</subject><subject>immunoglobulin G/A pemphigus</subject><subject>linear immunoglobulin A bullous dermatosis</subject><subject>Middle Aged</subject><subject>pemphigoid</subject><subject>pemphigus</subject><subject>Pemphigus - immunology</subject><subject>Pemphigus - pathology</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhSMEokNhzQ5ZYsOCtH7Ej1lWQztQKtjwEhvLSa5nXBI7tROVIvHfcTrtLNiAdWVfWd85vtYpiucEH5G8jgmrRKkIU0eE4Yo8KBb7m4fFAjPFS1pheVA8SekSY7rkBD8uDqigZCkZXxS_VyYBChYN0A9bt5kSunbjFrm-n3zYdKGeOufRGhnfopO8j64OrYP0GtXOt85v0BhQHbJk3AJyfoTYQNdNnYkoDaaBdCut8zM9-BH10NfReEC_goenxSNrugTP7s7D4vPZ6afV2_Li4_rd6uSibCohSCkoFo2wuDUVWCmNBcrBKmKhzY3gCitqCFXQGrmsW5yLWa6UtLQxTVuzw-LVzneI4WqCNOrepXnMPEiYkiZSccrwUvH_QAXBUlV0mdGXf6GXYYo-f2SmMBWCqpk63lFNDClFsHqIrjfxRhOs5xD1HJmeI9O3IWbFizvfqe6h3fP3qWWA74Br18HNv_z0-ZvTe-Nyp3NphJ97nYk_tJBMcv31w1qffVu9__L9nGnM_gDdjLYP</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Hosoda, Satomi</creator><creator>Adachi, Akimasa</creator><creator>Suzuki, Masayuki</creator><creator>Yamada, Tomoko</creator><creator>Komine, Mayumi</creator><creator>Murata, Satoru</creator><creator>Ohtsuki, Mamitaro</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone</title><author>Hosoda, Satomi ; Adachi, Akimasa ; Suzuki, Masayuki ; Yamada, Tomoko ; Komine, Mayumi ; Murata, Satoru ; Ohtsuki, Mamitaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4661-6206c6f0da4ef77afe25ef81fed25e658082a128eda79bd0bd03f5887f2cacdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Autoantibodies - blood</topic><topic>Autoantibodies - classification</topic><topic>Autoantibodies - metabolism</topic><topic>Basement Membrane - immunology</topic><topic>Basement Membrane - pathology</topic><topic>Extracellular Space - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin A - metabolism</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin G - metabolism</topic><topic>immunoglobulin G subclass</topic><topic>immunoglobulin G/A pemphigus</topic><topic>linear immunoglobulin A bullous dermatosis</topic><topic>Middle Aged</topic><topic>pemphigoid</topic><topic>pemphigus</topic><topic>Pemphigus - immunology</topic><topic>Pemphigus - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosoda, Satomi</creatorcontrib><creatorcontrib>Adachi, Akimasa</creatorcontrib><creatorcontrib>Suzuki, Masayuki</creatorcontrib><creatorcontrib>Yamada, Tomoko</creatorcontrib><creatorcontrib>Komine, Mayumi</creatorcontrib><creatorcontrib>Murata, Satoru</creatorcontrib><creatorcontrib>Ohtsuki, Mamitaro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosoda, Satomi</au><au>Adachi, Akimasa</au><au>Suzuki, Masayuki</au><au>Yamada, Tomoko</au><au>Komine, Mayumi</au><au>Murata, Satoru</au><au>Ohtsuki, Mamitaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2016-02</date><risdate>2016</risdate><volume>43</volume><issue>2</issue><spage>194</spage><epage>196</epage><pages>194-196</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo‐bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti‐ICS IgG bound to desmoglein‐3, while the anti‐BMZ antibodies bound to the epidermal side of 1 mol/L NaCl‐split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo‐bound and circulating anti‐ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti‐ICS antibodies belonged to IgG1 and IgG4, while the circulating anti‐BMZ antibodies to IgG1, IgG2 and IgG4.
We report a case involving a 62‐year‐old woman with in vivo‐bound immunoglobulin (Ig)G and IgA antibodies in both the intercellular space (ICS) and basement membrane zone (BMZ). Her clinical and histopathological features were identical with those of pemphigus vulgaris, while the immunopathological findings suggested IgG/IgA pemphigus. Direct immunofluorescence (IF) showed in vivo‐bound IgG and IgA antibodies in the ICS and BMZ, whereas indirect IF showed circulating IgG but not IgA antibodies in the ICS and BMZ. The anti‐ICS IgG bound to desmoglein‐3, while the anti‐BMZ antibodies bound to the epidermal side of 1 mol/L NaCl‐split skin. To the best of our knowledge, only two similar cases have been reported so far. Furthermore, we also examined IgG subclass distribution of the in vivo‐bound and circulating anti‐ICS and BMZ antibodies, and found that IgG1, IgG2 and IgG4 bound to ICS of the lesional skins, while IgG1 and IgG3 bound to the BMZ. The circulating anti‐ICS antibodies belonged to IgG1 and IgG4, while the circulating anti‐BMZ antibodies to IgG1, IgG2 and IgG4.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26219735</pmid><doi>10.1111/1346-8138.13041</doi><tpages>3</tpages></addata></record> |
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| subjects | Autoantibodies - blood Autoantibodies - classification Autoantibodies - metabolism Basement Membrane - immunology Basement Membrane - pathology Extracellular Space - immunology Female Humans Immunoglobulin A - metabolism Immunoglobulin G - blood Immunoglobulin G - classification Immunoglobulin G - metabolism immunoglobulin G subclass immunoglobulin G/A pemphigus linear immunoglobulin A bullous dermatosis Middle Aged pemphigoid pemphigus Pemphigus - immunology Pemphigus - pathology |
| title | Case of pemphigus with immunoglobulin G and A antibodies, binding to both the intercellular spaces and basement membrane zone |
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