Different patterns of allelic imbalance in sporadic tumors and tumors associated with long-term exposure to gamma-radiation
•We compare the prevalence of genotypes of SNP in tumors and matched normal tissues.•We consider the effects of gamma-radiation on the risk of the development of cancer.•We showed the phenomenon of allelic imbalance in tumors associated with radiation.•We demonstrated the phenomenon of allelic imbal...
Gespeichert in:
| Veröffentlicht in: | Mutation research. Genetic toxicology and environmental mutagenesis 2015-12, Vol.794, p.8-16 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 16 |
|---|---|
| container_issue | |
| container_start_page | 8 |
| container_title | Mutation research. Genetic toxicology and environmental mutagenesis |
| container_volume | 794 |
| creator | Litviakov, Nikolai V. Freidin, Maxim B. Sazonov, Aleksey E. Khalyuzova, Maria V. Buldakov, Mikhail A. Karbyshev, Mikhail S. Albakh, Еlena N. Isubakova, Daria S. Gagarin, Аleksey A. Nekrasov, Gennadiy B. Mironova, Elena B. Izosimov, Аndrey S. Takhauov, Ravil M. Karpov, Аndrei B. |
| description | •We compare the prevalence of genotypes of SNP in tumors and matched normal tissues.•We consider the effects of gamma-radiation on the risk of the development of cancer.•We showed the phenomenon of allelic imbalance in tumors associated with radiation.•We demonstrated the phenomenon of allelic imbalance in spontaneous tumors.
The study aimed to reveal cancer related mutations in DNA repair and cell cycle genes associated with chronic occupational exposure to gamma-radiation in personnel of the Siberian Group of Chemical Enterprises (SGCE). Mutations were analyzed by comparing genotypes of malignant tumors and matched normal tissues of 255 cancer patients including 98 exposed to external gamma-radiation (mean dose 128.1±150.5mSv). Also a genetic association analysis was carried out in a sample of 149 cancer patients and 908 healthy controls occupationally exposed to gamma-radiation (153.2±204.6mSv and 150.5±211.2mSv, respectively). Eight SNPs of genes of DNA excision repair were genotyped (rs13181, rs1052133, rs1042522, rs2305427, rs4244285, rs1045642, rs1805419 and rs1801133). The mutation profiles in heterozygous loci for selected SNP were different between sporadic tumors and tumors in patients exposed to radiation. In sporadic tumors, heterozygous genotype Arg/Pro of the rs1042522 SNP mutated into Arg/0 in 15 cases (9.6%) and 0/Pro in 14 cases (8.9%). The genotype Lys/Gln of the rs13181 SNP mutated into Lys/0 and 0/Gln in 9 and 4 cases, respectively. In tumors of patients exposed to low-level radiation, the rs1042522 Arg/0 mutated genotype was found in 12 cases (12.1%), while in 2 cases (2%) 0/Pro mutation was observed. Finally, the rs13181 0/Gln mutated genotype was observed in 15 cases (16,5%) . Thus, our study showed the difference in patterns of allelic imbalance in tumors appeared under low-level radiation exposure and spontaneous tumors for selected SNPs. This suggests different mechanisms of inactivation of heterozygous genotypes in sporadic and radiation-induced tumors. |
| doi_str_mv | 10.1016/j.mrgentox.2015.09.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1785230532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1383571815002284</els_id><sourcerecordid>1749613581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c376t-9cb94176cffea77e3bd453dc2a11e9f0ad2ad1f6ed4fcc9e99346445cddda3db3</originalsourceid><addsrcrecordid>eNqNkU1vFSEUhidGY2vrX2hI3LiZkY-BgZ2mfiZNurFrwsCZKzfDMAJja_zzcnPbLtzYFSfkOS_n8DTNBcEdwUS823ch7WAp8a6jmPAOqw5j9qw5JXJQLeOKPq81k6zlA5Enzauc9xhTzLB82ZxQIThTgzxt_nz00wSpJqHVlAJpyShOyMwzzN4iH0Yzm8UC8gvKa0zG1duyhZgyMot7LHOO1psCDt368gPNcdm1NS0guFtj3hKgEtHOhGDaQ4YpPi7nzYvJzBle359nzc3nT98vv7ZX11--XX64ai0bRGmVHVVPBmHroGYYgI2u58xZaggBNWHjqHFkEuD6yVoFSrFe9D23zjnD3MjOmrfH3DXFnxvkooPPFua6GMQtazJIThnmjD4B7ZUgjEtS0Tf_oPu4paUucqCkFFQqXClxpGyKOSeY9Jp8MOm3JlgfTOq9fjCpDyY1VrqarI0X9_HbGMA9tj2oq8D7IwD16355SDpbD1WV8wls0S76_73xF8S_tjg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1748862890</pqid></control><display><type>article</type><title>Different patterns of allelic imbalance in sporadic tumors and tumors associated with long-term exposure to gamma-radiation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Litviakov, Nikolai V. ; Freidin, Maxim B. ; Sazonov, Aleksey E. ; Khalyuzova, Maria V. ; Buldakov, Mikhail A. ; Karbyshev, Mikhail S. ; Albakh, Еlena N. ; Isubakova, Daria S. ; Gagarin, Аleksey A. ; Nekrasov, Gennadiy B. ; Mironova, Elena B. ; Izosimov, Аndrey S. ; Takhauov, Ravil M. ; Karpov, Аndrei B.</creator><creatorcontrib>Litviakov, Nikolai V. ; Freidin, Maxim B. ; Sazonov, Aleksey E. ; Khalyuzova, Maria V. ; Buldakov, Mikhail A. ; Karbyshev, Mikhail S. ; Albakh, Еlena N. ; Isubakova, Daria S. ; Gagarin, Аleksey A. ; Nekrasov, Gennadiy B. ; Mironova, Elena B. ; Izosimov, Аndrey S. ; Takhauov, Ravil M. ; Karpov, Аndrei B.</creatorcontrib><description>•We compare the prevalence of genotypes of SNP in tumors and matched normal tissues.•We consider the effects of gamma-radiation on the risk of the development of cancer.•We showed the phenomenon of allelic imbalance in tumors associated with radiation.•We demonstrated the phenomenon of allelic imbalance in spontaneous tumors.
The study aimed to reveal cancer related mutations in DNA repair and cell cycle genes associated with chronic occupational exposure to gamma-radiation in personnel of the Siberian Group of Chemical Enterprises (SGCE). Mutations were analyzed by comparing genotypes of malignant tumors and matched normal tissues of 255 cancer patients including 98 exposed to external gamma-radiation (mean dose 128.1±150.5mSv). Also a genetic association analysis was carried out in a sample of 149 cancer patients and 908 healthy controls occupationally exposed to gamma-radiation (153.2±204.6mSv and 150.5±211.2mSv, respectively). Eight SNPs of genes of DNA excision repair were genotyped (rs13181, rs1052133, rs1042522, rs2305427, rs4244285, rs1045642, rs1805419 and rs1801133). The mutation profiles in heterozygous loci for selected SNP were different between sporadic tumors and tumors in patients exposed to radiation. In sporadic tumors, heterozygous genotype Arg/Pro of the rs1042522 SNP mutated into Arg/0 in 15 cases (9.6%) and 0/Pro in 14 cases (8.9%). The genotype Lys/Gln of the rs13181 SNP mutated into Lys/0 and 0/Gln in 9 and 4 cases, respectively. In tumors of patients exposed to low-level radiation, the rs1042522 Arg/0 mutated genotype was found in 12 cases (12.1%), while in 2 cases (2%) 0/Pro mutation was observed. Finally, the rs13181 0/Gln mutated genotype was observed in 15 cases (16,5%) . Thus, our study showed the difference in patterns of allelic imbalance in tumors appeared under low-level radiation exposure and spontaneous tumors for selected SNPs. This suggests different mechanisms of inactivation of heterozygous genotypes in sporadic and radiation-induced tumors.</description><identifier>ISSN: 1383-5718</identifier><identifier>EISSN: 1879-3592</identifier><identifier>DOI: 10.1016/j.mrgentox.2015.09.003</identifier><identifier>PMID: 26653978</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Allelic Imbalance ; Case-Control Studies ; Cell cycle ; DNA Repair ; Female ; Gamma rays ; Gamma Rays - adverse effects ; Gene Frequency ; Genes ; Genetic Association Studies ; Genetic Loci ; Genetic polymorphism ; Genotype ; Genotype & phenotype ; Humans ; Male ; Malignant tumor ; Middle Aged ; Mutation ; Neoplasms - etiology ; Neoplasms - genetics ; Occupational Exposure - adverse effects ; Polymorphism, Single Nucleotide ; Tumors ; γ-Radiation</subject><ispartof>Mutation research. Genetic toxicology and environmental mutagenesis, 2015-12, Vol.794, p.8-16</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Dec 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c376t-9cb94176cffea77e3bd453dc2a11e9f0ad2ad1f6ed4fcc9e99346445cddda3db3</cites><orcidid>0000-0002-1439-6259</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1383571815002284$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26653978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Litviakov, Nikolai V.</creatorcontrib><creatorcontrib>Freidin, Maxim B.</creatorcontrib><creatorcontrib>Sazonov, Aleksey E.</creatorcontrib><creatorcontrib>Khalyuzova, Maria V.</creatorcontrib><creatorcontrib>Buldakov, Mikhail A.</creatorcontrib><creatorcontrib>Karbyshev, Mikhail S.</creatorcontrib><creatorcontrib>Albakh, Еlena N.</creatorcontrib><creatorcontrib>Isubakova, Daria S.</creatorcontrib><creatorcontrib>Gagarin, Аleksey A.</creatorcontrib><creatorcontrib>Nekrasov, Gennadiy B.</creatorcontrib><creatorcontrib>Mironova, Elena B.</creatorcontrib><creatorcontrib>Izosimov, Аndrey S.</creatorcontrib><creatorcontrib>Takhauov, Ravil M.</creatorcontrib><creatorcontrib>Karpov, Аndrei B.</creatorcontrib><title>Different patterns of allelic imbalance in sporadic tumors and tumors associated with long-term exposure to gamma-radiation</title><title>Mutation research. Genetic toxicology and environmental mutagenesis</title><addtitle>Mutat Res Genet Toxicol Environ Mutagen</addtitle><description>•We compare the prevalence of genotypes of SNP in tumors and matched normal tissues.•We consider the effects of gamma-radiation on the risk of the development of cancer.•We showed the phenomenon of allelic imbalance in tumors associated with radiation.•We demonstrated the phenomenon of allelic imbalance in spontaneous tumors.
The study aimed to reveal cancer related mutations in DNA repair and cell cycle genes associated with chronic occupational exposure to gamma-radiation in personnel of the Siberian Group of Chemical Enterprises (SGCE). Mutations were analyzed by comparing genotypes of malignant tumors and matched normal tissues of 255 cancer patients including 98 exposed to external gamma-radiation (mean dose 128.1±150.5mSv). Also a genetic association analysis was carried out in a sample of 149 cancer patients and 908 healthy controls occupationally exposed to gamma-radiation (153.2±204.6mSv and 150.5±211.2mSv, respectively). Eight SNPs of genes of DNA excision repair were genotyped (rs13181, rs1052133, rs1042522, rs2305427, rs4244285, rs1045642, rs1805419 and rs1801133). The mutation profiles in heterozygous loci for selected SNP were different between sporadic tumors and tumors in patients exposed to radiation. In sporadic tumors, heterozygous genotype Arg/Pro of the rs1042522 SNP mutated into Arg/0 in 15 cases (9.6%) and 0/Pro in 14 cases (8.9%). The genotype Lys/Gln of the rs13181 SNP mutated into Lys/0 and 0/Gln in 9 and 4 cases, respectively. In tumors of patients exposed to low-level radiation, the rs1042522 Arg/0 mutated genotype was found in 12 cases (12.1%), while in 2 cases (2%) 0/Pro mutation was observed. Finally, the rs13181 0/Gln mutated genotype was observed in 15 cases (16,5%) . Thus, our study showed the difference in patterns of allelic imbalance in tumors appeared under low-level radiation exposure and spontaneous tumors for selected SNPs. This suggests different mechanisms of inactivation of heterozygous genotypes in sporadic and radiation-induced tumors.</description><subject>Adult</subject><subject>Aged</subject><subject>Allelic Imbalance</subject><subject>Case-Control Studies</subject><subject>Cell cycle</subject><subject>DNA Repair</subject><subject>Female</subject><subject>Gamma rays</subject><subject>Gamma Rays - adverse effects</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Association Studies</subject><subject>Genetic Loci</subject><subject>Genetic polymorphism</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Male</subject><subject>Malignant tumor</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - genetics</subject><subject>Occupational Exposure - adverse effects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Tumors</subject><subject>γ-Radiation</subject><issn>1383-5718</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vFSEUhidGY2vrX2hI3LiZkY-BgZ2mfiZNurFrwsCZKzfDMAJja_zzcnPbLtzYFSfkOS_n8DTNBcEdwUS823ch7WAp8a6jmPAOqw5j9qw5JXJQLeOKPq81k6zlA5Enzauc9xhTzLB82ZxQIThTgzxt_nz00wSpJqHVlAJpyShOyMwzzN4iH0Yzm8UC8gvKa0zG1duyhZgyMot7LHOO1psCDt368gPNcdm1NS0guFtj3hKgEtHOhGDaQ4YpPi7nzYvJzBle359nzc3nT98vv7ZX11--XX64ai0bRGmVHVVPBmHroGYYgI2u58xZaggBNWHjqHFkEuD6yVoFSrFe9D23zjnD3MjOmrfH3DXFnxvkooPPFua6GMQtazJIThnmjD4B7ZUgjEtS0Tf_oPu4paUucqCkFFQqXClxpGyKOSeY9Jp8MOm3JlgfTOq9fjCpDyY1VrqarI0X9_HbGMA9tj2oq8D7IwD16355SDpbD1WV8wls0S76_73xF8S_tjg</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Litviakov, Nikolai V.</creator><creator>Freidin, Maxim B.</creator><creator>Sazonov, Aleksey E.</creator><creator>Khalyuzova, Maria V.</creator><creator>Buldakov, Mikhail A.</creator><creator>Karbyshev, Mikhail S.</creator><creator>Albakh, Еlena N.</creator><creator>Isubakova, Daria S.</creator><creator>Gagarin, Аleksey A.</creator><creator>Nekrasov, Gennadiy B.</creator><creator>Mironova, Elena B.</creator><creator>Izosimov, Аndrey S.</creator><creator>Takhauov, Ravil M.</creator><creator>Karpov, Аndrei B.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1439-6259</orcidid></search><sort><creationdate>201512</creationdate><title>Different patterns of allelic imbalance in sporadic tumors and tumors associated with long-term exposure to gamma-radiation</title><author>Litviakov, Nikolai V. ; Freidin, Maxim B. ; Sazonov, Aleksey E. ; Khalyuzova, Maria V. ; Buldakov, Mikhail A. ; Karbyshev, Mikhail S. ; Albakh, Еlena N. ; Isubakova, Daria S. ; Gagarin, Аleksey A. ; Nekrasov, Gennadiy B. ; Mironova, Elena B. ; Izosimov, Аndrey S. ; Takhauov, Ravil M. ; Karpov, Аndrei B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-9cb94176cffea77e3bd453dc2a11e9f0ad2ad1f6ed4fcc9e99346445cddda3db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allelic Imbalance</topic><topic>Case-Control Studies</topic><topic>Cell cycle</topic><topic>DNA Repair</topic><topic>Female</topic><topic>Gamma rays</topic><topic>Gamma Rays - adverse effects</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic Association Studies</topic><topic>Genetic Loci</topic><topic>Genetic polymorphism</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Male</topic><topic>Malignant tumor</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - genetics</topic><topic>Occupational Exposure - adverse effects</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Tumors</topic><topic>γ-Radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Litviakov, Nikolai V.</creatorcontrib><creatorcontrib>Freidin, Maxim B.</creatorcontrib><creatorcontrib>Sazonov, Aleksey E.</creatorcontrib><creatorcontrib>Khalyuzova, Maria V.</creatorcontrib><creatorcontrib>Buldakov, Mikhail A.</creatorcontrib><creatorcontrib>Karbyshev, Mikhail S.</creatorcontrib><creatorcontrib>Albakh, Еlena N.</creatorcontrib><creatorcontrib>Isubakova, Daria S.</creatorcontrib><creatorcontrib>Gagarin, Аleksey A.</creatorcontrib><creatorcontrib>Nekrasov, Gennadiy B.</creatorcontrib><creatorcontrib>Mironova, Elena B.</creatorcontrib><creatorcontrib>Izosimov, Аndrey S.</creatorcontrib><creatorcontrib>Takhauov, Ravil M.</creatorcontrib><creatorcontrib>Karpov, Аndrei B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Mutation research. Genetic toxicology and environmental mutagenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Litviakov, Nikolai V.</au><au>Freidin, Maxim B.</au><au>Sazonov, Aleksey E.</au><au>Khalyuzova, Maria V.</au><au>Buldakov, Mikhail A.</au><au>Karbyshev, Mikhail S.</au><au>Albakh, Еlena N.</au><au>Isubakova, Daria S.</au><au>Gagarin, Аleksey A.</au><au>Nekrasov, Gennadiy B.</au><au>Mironova, Elena B.</au><au>Izosimov, Аndrey S.</au><au>Takhauov, Ravil M.</au><au>Karpov, Аndrei B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different patterns of allelic imbalance in sporadic tumors and tumors associated with long-term exposure to gamma-radiation</atitle><jtitle>Mutation research. Genetic toxicology and environmental mutagenesis</jtitle><addtitle>Mutat Res Genet Toxicol Environ Mutagen</addtitle><date>2015-12</date><risdate>2015</risdate><volume>794</volume><spage>8</spage><epage>16</epage><pages>8-16</pages><issn>1383-5718</issn><eissn>1879-3592</eissn><abstract>•We compare the prevalence of genotypes of SNP in tumors and matched normal tissues.•We consider the effects of gamma-radiation on the risk of the development of cancer.•We showed the phenomenon of allelic imbalance in tumors associated with radiation.•We demonstrated the phenomenon of allelic imbalance in spontaneous tumors.
The study aimed to reveal cancer related mutations in DNA repair and cell cycle genes associated with chronic occupational exposure to gamma-radiation in personnel of the Siberian Group of Chemical Enterprises (SGCE). Mutations were analyzed by comparing genotypes of malignant tumors and matched normal tissues of 255 cancer patients including 98 exposed to external gamma-radiation (mean dose 128.1±150.5mSv). Also a genetic association analysis was carried out in a sample of 149 cancer patients and 908 healthy controls occupationally exposed to gamma-radiation (153.2±204.6mSv and 150.5±211.2mSv, respectively). Eight SNPs of genes of DNA excision repair were genotyped (rs13181, rs1052133, rs1042522, rs2305427, rs4244285, rs1045642, rs1805419 and rs1801133). The mutation profiles in heterozygous loci for selected SNP were different between sporadic tumors and tumors in patients exposed to radiation. In sporadic tumors, heterozygous genotype Arg/Pro of the rs1042522 SNP mutated into Arg/0 in 15 cases (9.6%) and 0/Pro in 14 cases (8.9%). The genotype Lys/Gln of the rs13181 SNP mutated into Lys/0 and 0/Gln in 9 and 4 cases, respectively. In tumors of patients exposed to low-level radiation, the rs1042522 Arg/0 mutated genotype was found in 12 cases (12.1%), while in 2 cases (2%) 0/Pro mutation was observed. Finally, the rs13181 0/Gln mutated genotype was observed in 15 cases (16,5%) . Thus, our study showed the difference in patterns of allelic imbalance in tumors appeared under low-level radiation exposure and spontaneous tumors for selected SNPs. This suggests different mechanisms of inactivation of heterozygous genotypes in sporadic and radiation-induced tumors.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26653978</pmid><doi>10.1016/j.mrgentox.2015.09.003</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1439-6259</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1383-5718 |
| ispartof | Mutation research. Genetic toxicology and environmental mutagenesis, 2015-12, Vol.794, p.8-16 |
| issn | 1383-5718 1879-3592 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1785230532 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Allelic Imbalance Case-Control Studies Cell cycle DNA Repair Female Gamma rays Gamma Rays - adverse effects Gene Frequency Genes Genetic Association Studies Genetic Loci Genetic polymorphism Genotype Genotype & phenotype Humans Male Malignant tumor Middle Aged Mutation Neoplasms - etiology Neoplasms - genetics Occupational Exposure - adverse effects Polymorphism, Single Nucleotide Tumors γ-Radiation |
| title | Different patterns of allelic imbalance in sporadic tumors and tumors associated with long-term exposure to gamma-radiation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T02%3A38%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20patterns%20of%20allelic%20imbalance%20in%20sporadic%20tumors%20and%20tumors%20associated%20with%20long-term%20exposure%20to%20gamma-radiation&rft.jtitle=Mutation%20research.%20Genetic%20toxicology%20and%20environmental%20mutagenesis&rft.au=Litviakov,%20Nikolai%20V.&rft.date=2015-12&rft.volume=794&rft.spage=8&rft.epage=16&rft.pages=8-16&rft.issn=1383-5718&rft.eissn=1879-3592&rft_id=info:doi/10.1016/j.mrgentox.2015.09.003&rft_dat=%3Cproquest_cross%3E1749613581%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1748862890&rft_id=info:pmid/26653978&rft_els_id=S1383571815002284&rfr_iscdi=true |