Mechanisms and Patterns of Intravascular Ultrasound In-Stent Restenosis Among Bare Metal Stents and First- and Second-Generation Drug-Eluting Stents
The most common causes of in-stent restenosis (ISR) are intimal hyperplasia and stent under expansion. The purpose of this study was to use intravascular ultrasound (IVUS) to compare the ISR mechanisms of bare metal stents (BMS), first-generation drug-eluting stents (DES), and second-generation DES....
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| Veröffentlicht in: | The American journal of cardiology 2015-11, Vol.116 (9), p.1351-1357 |
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| creator | Goto, Kosaku, MD, PhD Zhao, Zhijing, MD Matsumura, Mitsuaki, BS Dohi, Tomotaka, MD, PhD Kobayashi, Nobuaki, MD, PhD Kirtane, Ajay J., MD, SM Rabbani, LeRoy E., MD Collins, Michael B., MD Parikh, Manish A., MD Kodali, Susheel K., MD Leon, Martin B., MD Moses, Jeffrey W., MD Mintz, Gary S., MD Maehara, Akiko, MD |
| description | The most common causes of in-stent restenosis (ISR) are intimal hyperplasia and stent under expansion. The purpose of this study was to use intravascular ultrasound (IVUS) to compare the ISR mechanisms of bare metal stents (BMS), first-generation drug-eluting stents (DES), and second-generation DES. There were 298 ISR lesions including 52 BMS, 73 sirolimus-eluting stents, 52 paclitaxel-eluting stents, 16 zotarolimus-eluting stents, and 105 everolimus-eluting stent. Mean patient age was 66.6 ± 1.1 years, 74.2% were men, and 48.3% had diabetes mellitus. BMS restenosis presented later (70.0 ± 66.7 months) with more intimal hyperplasia compared with DES (BMS 58.6 ± 15.5%, first-generation DES 52.6 ± 20.9%, second-generation DES 48.2 ± 22.2%, p = 0.02). Although reference lumen areas were similar in BMS and first- and second-generation DES, restenotic DES were longer (BMS 21.8 ± 13.5 mm, first-generation DES 29.4 ± 16.1 mm, second-generation DES 32.1 ± 18.7 mm, p = 0.003), and stent areas were smaller (BMS 7.2 ± 2.4 mm2 , first-generation DES 6.1 ± 2.1 mm2 , second-generation DES 5.7 ± 2.0 mm2 , p |
| doi_str_mv | 10.1016/j.amjcard.2015.07.058 |
| format | Article |
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The purpose of this study was to use intravascular ultrasound (IVUS) to compare the ISR mechanisms of bare metal stents (BMS), first-generation drug-eluting stents (DES), and second-generation DES. There were 298 ISR lesions including 52 BMS, 73 sirolimus-eluting stents, 52 paclitaxel-eluting stents, 16 zotarolimus-eluting stents, and 105 everolimus-eluting stent. Mean patient age was 66.6 ± 1.1 years, 74.2% were men, and 48.3% had diabetes mellitus. BMS restenosis presented later (70.0 ± 66.7 months) with more intimal hyperplasia compared with DES (BMS 58.6 ± 15.5%, first-generation DES 52.6 ± 20.9%, second-generation DES 48.2 ± 22.2%, p = 0.02). Although reference lumen areas were similar in BMS and first- and second-generation DES, restenotic DES were longer (BMS 21.8 ± 13.5 mm, first-generation DES 29.4 ± 16.1 mm, second-generation DES 32.1 ± 18.7 mm, p = 0.003), and stent areas were smaller (BMS 7.2 ± 2.4 mm2 , first-generation DES 6.1 ± 2.1 mm2 , second-generation DES 5.7 ± 2.0 mm2 , p <0.001). Stent fracture was seen only in DES (first-generation DES 7 [5.0%], second-generation DES 8 [7.4%], p = 0.13). In conclusion, restenotic first- and second-generation DES were characterized by less neointimal hyperplasia, smaller stent areas, longer stent lengths, and more stent fractures than restenotic BMS.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2015.07.058</identifier><identifier>PMID: 26341188</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Angioplasty ; Cardiovascular ; Coronary Restenosis - diagnostic imaging ; Coronary Restenosis - prevention & control ; Coronary Restenosis - surgery ; Drug-Eluting Stents - adverse effects ; Everolimus ; Female ; Heart attacks ; Humans ; Immunosuppressive Agents ; Male ; Medical imaging ; Metals ; Middle Aged ; Neointima - diagnostic imaging ; Paclitaxel ; Percutaneous Coronary Intervention ; Prosthesis Design ; Retrospective Studies ; Risk Factors ; Sirolimus - analogs & derivatives ; Standard deviation ; Stents ; Stents - adverse effects ; Time Factors ; Treatment Outcome ; Ultrasonography, Interventional ; Variables</subject><ispartof>The American journal of cardiology, 2015-11, Vol.116 (9), p.1351-1357</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 1, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-6213ac7870ecf5c6c58230ded3038ad60ee8c5711c7b696f2dad47c1ac1389e3</citedby><cites>FETCH-LOGICAL-c617t-6213ac7870ecf5c6c58230ded3038ad60ee8c5711c7b696f2dad47c1ac1389e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914915017610$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26341188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goto, Kosaku, MD, PhD</creatorcontrib><creatorcontrib>Zhao, Zhijing, MD</creatorcontrib><creatorcontrib>Matsumura, Mitsuaki, BS</creatorcontrib><creatorcontrib>Dohi, Tomotaka, MD, PhD</creatorcontrib><creatorcontrib>Kobayashi, Nobuaki, MD, PhD</creatorcontrib><creatorcontrib>Kirtane, Ajay J., MD, SM</creatorcontrib><creatorcontrib>Rabbani, LeRoy E., MD</creatorcontrib><creatorcontrib>Collins, Michael B., MD</creatorcontrib><creatorcontrib>Parikh, Manish A., MD</creatorcontrib><creatorcontrib>Kodali, Susheel K., MD</creatorcontrib><creatorcontrib>Leon, Martin B., MD</creatorcontrib><creatorcontrib>Moses, Jeffrey W., MD</creatorcontrib><creatorcontrib>Mintz, Gary S., MD</creatorcontrib><creatorcontrib>Maehara, Akiko, MD</creatorcontrib><title>Mechanisms and Patterns of Intravascular Ultrasound In-Stent Restenosis Among Bare Metal Stents and First- and Second-Generation Drug-Eluting Stents</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The most common causes of in-stent restenosis (ISR) are intimal hyperplasia and stent under expansion. The purpose of this study was to use intravascular ultrasound (IVUS) to compare the ISR mechanisms of bare metal stents (BMS), first-generation drug-eluting stents (DES), and second-generation DES. There were 298 ISR lesions including 52 BMS, 73 sirolimus-eluting stents, 52 paclitaxel-eluting stents, 16 zotarolimus-eluting stents, and 105 everolimus-eluting stent. Mean patient age was 66.6 ± 1.1 years, 74.2% were men, and 48.3% had diabetes mellitus. BMS restenosis presented later (70.0 ± 66.7 months) with more intimal hyperplasia compared with DES (BMS 58.6 ± 15.5%, first-generation DES 52.6 ± 20.9%, second-generation DES 48.2 ± 22.2%, p = 0.02). Although reference lumen areas were similar in BMS and first- and second-generation DES, restenotic DES were longer (BMS 21.8 ± 13.5 mm, first-generation DES 29.4 ± 16.1 mm, second-generation DES 32.1 ± 18.7 mm, p = 0.003), and stent areas were smaller (BMS 7.2 ± 2.4 mm2 , first-generation DES 6.1 ± 2.1 mm2 , second-generation DES 5.7 ± 2.0 mm2 , p <0.001). Stent fracture was seen only in DES (first-generation DES 7 [5.0%], second-generation DES 8 [7.4%], p = 0.13). In conclusion, restenotic first- and second-generation DES were characterized by less neointimal hyperplasia, smaller stent areas, longer stent lengths, and more stent fractures than restenotic BMS.</description><subject>Aged</subject><subject>Angioplasty</subject><subject>Cardiovascular</subject><subject>Coronary Restenosis - diagnostic imaging</subject><subject>Coronary Restenosis - prevention & control</subject><subject>Coronary Restenosis - surgery</subject><subject>Drug-Eluting Stents - adverse effects</subject><subject>Everolimus</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Immunosuppressive Agents</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Metals</subject><subject>Middle Aged</subject><subject>Neointima - diagnostic imaging</subject><subject>Paclitaxel</subject><subject>Percutaneous Coronary Intervention</subject><subject>Prosthesis Design</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sirolimus - analogs & derivatives</subject><subject>Standard deviation</subject><subject>Stents</subject><subject>Stents - adverse effects</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Interventional</subject><subject>Variables</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks9u1DAQxiMEokvhEUCWuHBJ8Nib2LmASmnLSq1AbDlbrj1bvCR2azuV-h48MN4_gNQLnMYj_b7Pmvmmql4CbYBC93bd6HFtdLQNo9A2VDS0lY-qGUjR19ADf1zNKKWs7mHeH1TPUlqXFqDtnlYHrONzACln1c8LNN-1d2lMRHtLvuicMfpEwoosfI76TiczDTqSb0PpUpgKtPD1MqPP5CumUkNyiRyNwV-TDzoiucCsB7IldqanLqZcb59LNMHb-gw9Rp1d8ORjnK7rk2HKruh3oufVk5UeEr7Y18Pq8vTk8vhTff75bHF8dF6bDkSuOwZcGyEFRbNqTWdayTi1aDnlUtuOIkrTCgAjrrq-WzGr7VwY0Aa47JEfVm92tjcx3E5lFDW6ZHAYtMcwJQVCtsUQWvgPlLGeSQ6soK8foOswRV_m2FJz0QsuC9XuKBNDShFX6ia6Ucd7BVRtAlZrtQ9YbQJWVKgScNG92rtPVyPaP6rfiRbg_Q7Asrg7h1El49AbtC6iycoG988v3j1wMIPzzujhB95j-juNSkxRtdxc2ebIoKUgOqD8FzL1zuk</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Goto, Kosaku, MD, PhD</creator><creator>Zhao, Zhijing, MD</creator><creator>Matsumura, Mitsuaki, BS</creator><creator>Dohi, Tomotaka, MD, PhD</creator><creator>Kobayashi, Nobuaki, MD, PhD</creator><creator>Kirtane, Ajay J., MD, SM</creator><creator>Rabbani, LeRoy E., MD</creator><creator>Collins, Michael B., MD</creator><creator>Parikh, Manish A., MD</creator><creator>Kodali, Susheel K., MD</creator><creator>Leon, Martin B., MD</creator><creator>Moses, Jeffrey W., MD</creator><creator>Mintz, Gary S., MD</creator><creator>Maehara, Akiko, MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20151101</creationdate><title>Mechanisms and Patterns of Intravascular Ultrasound In-Stent Restenosis Among Bare Metal Stents and First- and Second-Generation Drug-Eluting Stents</title><author>Goto, Kosaku, MD, PhD ; Zhao, Zhijing, MD ; Matsumura, Mitsuaki, BS ; Dohi, Tomotaka, MD, PhD ; Kobayashi, Nobuaki, MD, PhD ; Kirtane, Ajay J., MD, SM ; Rabbani, LeRoy E., MD ; Collins, Michael B., MD ; Parikh, Manish A., MD ; Kodali, Susheel K., MD ; Leon, Martin B., MD ; Moses, Jeffrey W., MD ; Mintz, Gary S., MD ; Maehara, Akiko, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-6213ac7870ecf5c6c58230ded3038ad60ee8c5711c7b696f2dad47c1ac1389e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Angioplasty</topic><topic>Cardiovascular</topic><topic>Coronary Restenosis - diagnostic imaging</topic><topic>Coronary Restenosis - prevention & control</topic><topic>Coronary Restenosis - surgery</topic><topic>Drug-Eluting Stents - adverse effects</topic><topic>Everolimus</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Immunosuppressive Agents</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Metals</topic><topic>Middle Aged</topic><topic>Neointima - diagnostic imaging</topic><topic>Paclitaxel</topic><topic>Percutaneous Coronary Intervention</topic><topic>Prosthesis Design</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sirolimus - analogs & derivatives</topic><topic>Standard deviation</topic><topic>Stents</topic><topic>Stents - adverse effects</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Interventional</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goto, Kosaku, MD, PhD</creatorcontrib><creatorcontrib>Zhao, Zhijing, MD</creatorcontrib><creatorcontrib>Matsumura, Mitsuaki, BS</creatorcontrib><creatorcontrib>Dohi, Tomotaka, MD, PhD</creatorcontrib><creatorcontrib>Kobayashi, Nobuaki, MD, PhD</creatorcontrib><creatorcontrib>Kirtane, Ajay J., MD, SM</creatorcontrib><creatorcontrib>Rabbani, LeRoy E., MD</creatorcontrib><creatorcontrib>Collins, Michael B., MD</creatorcontrib><creatorcontrib>Parikh, Manish A., MD</creatorcontrib><creatorcontrib>Kodali, Susheel K., MD</creatorcontrib><creatorcontrib>Leon, Martin B., MD</creatorcontrib><creatorcontrib>Moses, Jeffrey W., MD</creatorcontrib><creatorcontrib>Mintz, Gary S., MD</creatorcontrib><creatorcontrib>Maehara, Akiko, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goto, Kosaku, MD, PhD</au><au>Zhao, Zhijing, MD</au><au>Matsumura, Mitsuaki, BS</au><au>Dohi, Tomotaka, MD, PhD</au><au>Kobayashi, Nobuaki, MD, PhD</au><au>Kirtane, Ajay J., MD, SM</au><au>Rabbani, LeRoy E., MD</au><au>Collins, Michael B., MD</au><au>Parikh, Manish A., MD</au><au>Kodali, Susheel K., MD</au><au>Leon, Martin B., MD</au><au>Moses, Jeffrey W., MD</au><au>Mintz, Gary S., MD</au><au>Maehara, Akiko, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanisms and Patterns of Intravascular Ultrasound In-Stent Restenosis Among Bare Metal Stents and First- and Second-Generation Drug-Eluting Stents</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>116</volume><issue>9</issue><spage>1351</spage><epage>1357</epage><pages>1351-1357</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The most common causes of in-stent restenosis (ISR) are intimal hyperplasia and stent under expansion. The purpose of this study was to use intravascular ultrasound (IVUS) to compare the ISR mechanisms of bare metal stents (BMS), first-generation drug-eluting stents (DES), and second-generation DES. There were 298 ISR lesions including 52 BMS, 73 sirolimus-eluting stents, 52 paclitaxel-eluting stents, 16 zotarolimus-eluting stents, and 105 everolimus-eluting stent. Mean patient age was 66.6 ± 1.1 years, 74.2% were men, and 48.3% had diabetes mellitus. BMS restenosis presented later (70.0 ± 66.7 months) with more intimal hyperplasia compared with DES (BMS 58.6 ± 15.5%, first-generation DES 52.6 ± 20.9%, second-generation DES 48.2 ± 22.2%, p = 0.02). Although reference lumen areas were similar in BMS and first- and second-generation DES, restenotic DES were longer (BMS 21.8 ± 13.5 mm, first-generation DES 29.4 ± 16.1 mm, second-generation DES 32.1 ± 18.7 mm, p = 0.003), and stent areas were smaller (BMS 7.2 ± 2.4 mm2 , first-generation DES 6.1 ± 2.1 mm2 , second-generation DES 5.7 ± 2.0 mm2 , p <0.001). Stent fracture was seen only in DES (first-generation DES 7 [5.0%], second-generation DES 8 [7.4%], p = 0.13). In conclusion, restenotic first- and second-generation DES were characterized by less neointimal hyperplasia, smaller stent areas, longer stent lengths, and more stent fractures than restenotic BMS.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26341188</pmid><doi>10.1016/j.amjcard.2015.07.058</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Angioplasty Cardiovascular Coronary Restenosis - diagnostic imaging Coronary Restenosis - prevention & control Coronary Restenosis - surgery Drug-Eluting Stents - adverse effects Everolimus Female Heart attacks Humans Immunosuppressive Agents Male Medical imaging Metals Middle Aged Neointima - diagnostic imaging Paclitaxel Percutaneous Coronary Intervention Prosthesis Design Retrospective Studies Risk Factors Sirolimus - analogs & derivatives Standard deviation Stents Stents - adverse effects Time Factors Treatment Outcome Ultrasonography, Interventional Variables |
| title | Mechanisms and Patterns of Intravascular Ultrasound In-Stent Restenosis Among Bare Metal Stents and First- and Second-Generation Drug-Eluting Stents |
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